{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T04:16:35Z","timestamp":1726632995772},"reference-count":5,"publisher":"American College of Physicians","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.acpjournals.org\/journal\/aim\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Intern Med"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.7326\/annals-24-01751-jc","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T21:00:55Z","timestamp":1725310855000},"page":"JC103","source":"Crossref","is-referenced-by-count":0,"title":["In sepsis or septic shock, prolonged vs. intermittent infusion of \u03b2-lactam antibiotics reduces mortality at 90 d"],"prefix":"10.7326","volume":"177","author":[{"given":"Morgan K.","family":"Walker","sequence":"first","affiliation":[{"name":"National Institutes of Health, Critical Care Medicine Department, Bethesda, Maryland, USA (M.K.W., J.R.S.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"Strich","sequence":"additional","affiliation":[{"name":"National Institutes of Health, Critical Care Medicine Department, Bethesda, Maryland, USA (M.K.W., J.R.S.)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4285","reference":[{"key":"ANNALS-24-01751-R1","doi-asserted-by":"crossref","unstructured":"Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395:200-211. [PMID: 31954465]","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"ANNALS-24-01751-R2","doi-asserted-by":"crossref","unstructured":"Gatti M, Cojutti PG, Pea F. Impact of attaining aggressive vs. conservative PK\/PD target on the clinical efficacy of beta-lactams for the treatment of gram-negative infections in the critically ill patients: a systematic review and meta-analysis. Crit Care. 2024;28:123. [PMID: 38627763]","DOI":"10.1186\/s13054-024-04911-5"},{"key":"ANNALS-24-01751-R3","doi-asserted-by":"crossref","unstructured":"Roberts JA, Abdul-Aziz MH, Davis JS, et al. Continuous versus intermittent \u03b2-lactam infusion in severe sepsis. A meta-analysis of individual patient data from randomized trials. Am J Respir Crit Care Med. 2016;194:681-691. [PMID: 26974879]","DOI":"10.1164\/rccm.201601-0024OC"},{"key":"ANNALS-24-01751-R4","unstructured":"Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Crit Care Med. 2021;49:e1063-e1143. [PMID: 34605781]"},{"key":"ANNALS-24-01751-R5","doi-asserted-by":"crossref","unstructured":"Karaba SM, Cosgrove SE, Lee JH, et al. Extended-infusion \u03b2-lactam therapy, mortality, and subsequent antibiotic resistance among hospitalized adults with gram-negative bloodstream infections. JAMA Netw Open. 2024;7:e2418234. [PMID: 38954416]","DOI":"10.1001\/jamanetworkopen.2024.18234"}],"container-title":["Annals of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.acpjournals.org\/doi\/pdf\/10.7326\/ANNALS-24-01751-JC","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.acpjournals.org\/doi\/full-xml\/10.7326\/ANNALS-24-01751-JC","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T21:02:57Z","timestamp":1726520577000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.acpjournals.org\/doi\/10.7326\/ANNALS-24-01751-JC"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":5,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.7326\/ANNALS-24-01751-JC"],"URL":"https:\/\/doi.org\/10.7326\/annals-24-01751-jc","relation":{},"ISSN":["0003-4819","1539-3704"],"issn-type":[{"type":"print","value":"0003-4819"},{"type":"electronic","value":"1539-3704"}],"subject":[],"published":{"date-parts":[[2024,9]]}}}