{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:39:43Z","timestamp":1792445983290,"version":"4.5.0"},"reference-count":66,"publisher":"American College of Physicians","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.acpjournals.org\/journal\/aim\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Intern Med"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.7326\/annals-25-05519","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:00:37Z","timestamp":1788210037000},"page":"1412-1429","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Glucagon-like Peptide-1 Receptor Agonists and Co-agonists for Weight Loss Among Adults Without Diabetes"],"prefix":"10.7326","volume":"179","author":[{"given":"Areesha","family":"Moiz","sequence":"first","affiliation":[{"name":"Centre of Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada (A.M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6055-0088","authenticated-orcid":false,"given":"Kristian B.","family":"Filion","sequence":"additional","affiliation":[{"name":"Centre of Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, and Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, and Department of Medicine, McGill University, Montreal, Quebec, Canada (K.B.F.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron E.","family":"Samuels","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, McGill University, Montreal, Quebec, Canada (A.E.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8326-7274","authenticated-orcid":false,"given":"Michael A.","family":"Tsoukas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medicine, and Division of Endocrinology and Metabolism, McGill University, Montreal, Quebec, Canada (M.A.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4877-557X","authenticated-orcid":false,"given":"Oriana H.Y.","family":"Yu","sequence":"additional","affiliation":[{"name":"Centre of Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, and Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, Department of Medicine, and Division of Endocrinology and Metabolism, McGill University, Montreal, Quebec, Canada (O.H.Y.Y., T.M.P.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tricia M.","family":"Peters","sequence":"additional","affiliation":[{"name":"Centre of Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, and Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, Department of Medicine, and Division of Endocrinology and Metabolism, McGill University, Montreal, Quebec, Canada (O.H.Y.Y., T.M.P.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"Centre of Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, and Department of Medicine, McGill University, and Division of Cardiology, Jewish General Hospital\/McGill University, Montreal, Quebec, Canada (M.J.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4285","reference":[{"key":"r1-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS-24-01590"},{"key":"r2-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"r3-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6890"},{"key":"r4-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"r5-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(25)00226-8"},{"key":"r6-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2500969"},{"key":"r7-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2025.3599"},{"key":"r8-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2511774"},{"key":"r9-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2025.03.011"},{"key":"r10-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(24)00377-2"},{"key":"r11-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16534"},{"key":"r12-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2504214"},{"key":"r13-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16005"},{"key":"r14-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/dom.70040"},{"key":"r15-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)01185-7"},{"key":"r16-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2502081"},{"key":"r17-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(25)00402-4"},{"key":"r18-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2416394"},{"key":"r19-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15360"},{"key":"r20-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101691"},{"key":"r21-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23481"},{"key":"r22-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00179-0"},{"key":"r23-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.158"},{"key":"r24-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22726"},{"key":"r25-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411892"},{"key":"r26-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14280"},{"key":"r27-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(24)00182-7"},{"key":"r28-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31773-2"},{"key":"r29-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.23619"},{"key":"r30-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.1831"},{"key":"r31-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"r32-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02026-4"},{"key":"r33-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15802"},{"key":"r34-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01185-6"},{"key":"r35-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2302392"},{"key":"r36-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206038"},{"key":"r37-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13824"},{"key":"r38-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.03.017"},{"key":"r39-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1203"},{"key":"r40-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15407"},{"key":"r41-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12432"},{"key":"r42-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14948"},{"key":"r43-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00356-X"},{"key":"r44-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2301972"},{"key":"r45-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1136\/bmjph-2023-000245"},{"key":"r46-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaf205"},{"key":"r47-ANNALS2505519","unstructured":"Pfizer.\n                      Pfizer provides update on GLP-1-RA clinical development program for adults with obesity and type 2 diabetes mellitus. Accessed at www.pfizer.com\/news\/press-release\/press-release-detail\/pfizer-provides-update-glp-1-ra-clinical-development on 22 April 2026."},{"key":"r48-ANNALS2505519","unstructured":"Pfizer.\n                      Pfizer provides update on oral GLP-1 receptor agonist danuglipron. Accessed at www.pfizer.com\/news\/press-release\/press-release-detail\/pfizer-provides-update-oral-glp-1-receptor-agonist on 22 April 2026."},{"key":"r49-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-0241"},{"key":"r50-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15869"},{"key":"r51-ANNALS2505519","unstructured":"Novo Nordisk\n                      . CagriSema demonstrated 23% weight loss in an open-label head-to-head REDEFINE 4 trial in people with obesity, the primary endpoint was not achieved. Accessed at www.novonordisk.com\/content\/nncorp\/global\/en\/news-and-media\/news-and-ir-materials\/news-details.html?id=916501 on 10 April 2026."},{"key":"r52-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/dom.70429"},{"key":"r53-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-026-02586-8"},{"key":"r54-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(25)00141-X"},{"key":"r55-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2411528"},{"key":"r56-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44067-4"},{"key":"r57-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(25)00164-0"},{"key":"r58-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15064"},{"key":"r59-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"r60-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2024.156113"},{"key":"r61-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15728"},{"key":"r62-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS-25-00478"},{"key":"r63-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2026.102665"},{"key":"r64-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS-25-03519"},{"key":"r65-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15620"},{"key":"r66-ANNALS2505519","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-026-04204-0"}],"container-title":["Annals of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.acpjournals.org\/doi\/pdf\/10.7326\/ANNALS-25-05519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.acpjournals.org\/doi\/full-xml\/10.7326\/ANNALS-25-05519","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:02:19Z","timestamp":1792443739000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.acpjournals.org\/doi\/10.7326\/ANNALS-25-05519"}},"subtitle":["An Updated Systematic Review"],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":66,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.7326\/ANNALS-25-05519"],"URL":"https:\/\/doi.org\/10.7326\/annals-25-05519","relation":{},"ISSN":["0003-4819","1539-3704"],"issn-type":[{"value":"0003-4819","type":"print"},{"value":"1539-3704","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]}}}