{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:19:35Z","timestamp":1791839975765,"version":"4.3.4"},"reference-count":34,"publisher":"American College of Physicians","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Intern Med"],"published-print":{"date-parts":[[2015,2,3]]},"DOI":"10.7326\/m14-0773","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T23:30:29Z","timestamp":1419291029000},"page":"184-191","source":"Crossref","is-referenced-by-count":245,"title":["Effects of Blood Pressure Reduction in Mild Hypertension"],"prefix":"10.7326","volume":"162","author":[{"given":"Johan","family":"Sundstr\u00f6m","sequence":"first","affiliation":[{"name":"From Uppsala University, Uppsala, Sweden; Sydney University, Sydney, Australia; University of Auckland, Auckland, New Zealand; University of Oxford, Oxford, United Kingdom; and Imperial College, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisatomi","family":"Arima","sequence":"additional","affiliation":[{"name":"From Uppsala University, Uppsala, Sweden; Sydney University, Sydney, Australia; University of Auckland, Auckland, New Zealand; University of Oxford, Oxford, United Kingdom; and Imperial College, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod","family":"Jackson","sequence":"additional","affiliation":[{"name":"From Uppsala University, Uppsala, Sweden; Sydney University, Sydney, Australia; University of Auckland, Auckland, New Zealand; University of Oxford, Oxford, United Kingdom; and Imperial College, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Turnbull","sequence":"additional","affiliation":[{"name":"From Uppsala University, Uppsala, Sweden; Sydney University, Sydney, Australia; University of Auckland, Auckland, New Zealand; University of Oxford, Oxford, United Kingdom; and Imperial College, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazem","family":"Rahimi","sequence":"additional","affiliation":[{"name":"From Uppsala University, Uppsala, Sweden; Sydney University, Sydney, Australia; University of Auckland, Auckland, New Zealand; University of Oxford, Oxford, United Kingdom; and Imperial College, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Chalmers","sequence":"additional","affiliation":[{"name":"From Uppsala University, Uppsala, Sweden; Sydney University, Sydney, Australia; University of Auckland, Auckland, New Zealand; University of Oxford, Oxford, United Kingdom; and Imperial College, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Woodward","sequence":"additional","affiliation":[{"name":"From Uppsala University, Uppsala, Sweden; Sydney University, Sydney, Australia; University of Auckland, Auckland, New Zealand; University of Oxford, Oxford, United Kingdom; and Imperial College, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Neal","sequence":"additional","affiliation":[{"name":"From Uppsala University, Uppsala, Sweden; Sydney University, Sydney, Australia; University of Auckland, Auckland, New Zealand; University of Oxford, Oxford, United Kingdom; and Imperial College, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Blood Pressure Lowering Treatment Trialists' Collaboration*","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4285","reference":[{"key":"r1-6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61766-8"},{"key":"r2-6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62036-3"},{"key":"r3-6","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.3.869"},{"key":"r4-6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht151"},{"key":"r5-6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b1665"},{"key":"r6-6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11911-8"},{"key":"r7-6","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006742.pub2"},{"key":"r8-6","first-page":"127","volume":"16","year":"1998","journal-title":"J Hypertens"},{"key":"r9-6","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3280bad9b4"},{"key":"r10-6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14739-3"},{"key":"r11-6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"r12-6","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3165"},{"key":"r13-6","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2009.77"},{"key":"r14-6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.699579"},{"key":"r15-6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"r16-6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1749-6632.1978.tb25604.x","volume":"304","year":"1978","journal-title":"Ann N Y Acad Sci"},{"key":"r17-6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.291.6488.97"},{"key":"r18-6","first-page":"1261","volume":"1","year":"1980","journal-title":"Lancet"},{"key":"r19-6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7160.703"},{"key":"r20-6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.15.1748"},{"key":"r21-6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803053381003"},{"key":"r22-6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00213.x"},{"key":"r23-6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61303-8"},{"key":"r24-6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042167"},{"key":"r25-6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.37970.629537.0D"},{"key":"r26-6","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00736-1"},{"key":"r27-6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000146378.65439.7A"},{"key":"r28-6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03307-9"},{"key":"r29-6","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32835f7eef"},{"key":"r30-6","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.12.1410"},{"key":"r31-6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-154-9-201105030-00008"},{"key":"r32-6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-398"},{"key":"r33-6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.535922"},{"key":"r34-6","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200309000-00026"}],"container-title":["Annals of Internal Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T15:52:53Z","timestamp":1630943573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.acpjournals.org\/doi\/10.7326\/M14-0773"}},"subtitle":["A Systematic Review and Meta-analysis"],"short-title":[],"issued":{"date-parts":[[2015,2,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,2,3]]}},"alternative-id":["10.7326\/M14-0773"],"URL":"https:\/\/doi.org\/10.7326\/m14-0773","relation":{},"ISSN":["0003-4819","1539-3704"],"issn-type":[{"value":"0003-4819","type":"print"},{"value":"1539-3704","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,3]]}}}