{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:09:49Z","timestamp":1776398989035,"version":"3.51.2"},"reference-count":19,"publisher":"American College of Physicians","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Intern Med"],"published-print":{"date-parts":[[2015,12,15]]},"DOI":"10.7326\/m15-0949","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T18:31:02Z","timestamp":1448303462000},"page":"908-917","source":"Crossref","is-referenced-by-count":21,"title":["HIV Salvage Therapy Does Not Require Nucleoside Reverse Transcriptase Inhibitors"],"prefix":"10.7326","volume":"163","author":[{"given":"Karen T.","family":"Tashima","sequence":"first","affiliation":[{"name":"From The Miriam Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; Harvard T.H. Chan School of Public Health and Massachusetts General Hospital, Boston, Massachusetts; University of Cincinnati College of Medicine, Cincinnati, Ohio; Johns Hopkins Hospital, Baltimore, Maryland; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama;"},{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; West Virginia University School of Medicine, Morgantown, West Virginia; University of Puerto Rico, San Juan, Puerto Rico; Weill Cornell Medical College, New York, New York; and Gilead Sciences, Foster City, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M.","family":"Smeaton","sequence":"additional","affiliation":[{"name":"From The Miriam Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; Harvard T.H. Chan School of Public Health and Massachusetts General Hospital, Boston, Massachusetts; University of Cincinnati College of Medicine, Cincinnati, Ohio; Johns Hopkins Hospital, Baltimore, Maryland; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama;"},{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; West Virginia University School of Medicine, Morgantown, West Virginia; University of Puerto Rico, San Juan, Puerto Rico; Weill Cornell Medical College, New York, New York; and Gilead Sciences, Foster City, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl J.","family":"Fichtenbaum","sequence":"additional","affiliation":[{"name":"From The Miriam Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; Harvard T.H. Chan School of Public Health and Massachusetts General Hospital, Boston, Massachusetts; University of Cincinnati College of Medicine, Cincinnati, Ohio; Johns Hopkins Hospital, Baltimore, Maryland; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama;"},{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; West Virginia University School of Medicine, Morgantown, West Virginia; University of Puerto Rico, San Juan, Puerto Rico; Weill Cornell Medical College, New York, New York; and Gilead Sciences, Foster City, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Andrade","sequence":"additional","affiliation":[{"name":"From The Miriam Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; Harvard T.H. Chan School of Public Health and Massachusetts General Hospital, Boston, Massachusetts; University of Cincinnati College of Medicine, Cincinnati, Ohio; Johns Hopkins Hospital, Baltimore, Maryland; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama;"},{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; West Virginia University School of Medicine, Morgantown, West Virginia; University of Puerto Rico, San Juan, Puerto Rico; Weill Cornell Medical College, New York, New York; and Gilead Sciences, Foster City, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J.","family":"Eron","sequence":"additional","affiliation":[{"name":"From The Miriam Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; Harvard T.H. Chan School of Public Health and Massachusetts General Hospital, Boston, Massachusetts; University of Cincinnati College of Medicine, Cincinnati, Ohio; Johns Hopkins Hospital, Baltimore, Maryland; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama;"},{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; West Virginia University School of Medicine, Morgantown, West Virginia; University of Puerto Rico, San Juan, Puerto Rico; Weill Cornell Medical College, New York, New York; and Gilead Sciences, Foster City, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh T.","family":"Gandhi","sequence":"additional","affiliation":[{"name":"From The Miriam Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; Harvard T.H. Chan School of Public Health and Massachusetts General Hospital, Boston, Massachusetts; University of Cincinnati College of Medicine, Cincinnati, Ohio; Johns Hopkins Hospital, Baltimore, Maryland; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama;"},{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; West Virginia University School of Medicine, Morgantown, West Virginia; University of Puerto Rico, San Juan, Puerto Rico; Weill Cornell Medical College, New York, New York; and Gilead Sciences, Foster City, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"From The Miriam Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; Harvard T.H. Chan School of Public Health and Massachusetts General Hospital, Boston, Massachusetts; University of Cincinnati College of Medicine, Cincinnati, Ohio; Johns Hopkins Hospital, Baltimore, Maryland; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama;"},{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; West Virginia University School of Medicine, Morgantown, West Virginia; University of Puerto Rico, San Juan, Puerto Rico; Weill Cornell Medical College, New York, New York; and Gilead Sciences, Foster City, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin L.","family":"Klingman","sequence":"additional","affiliation":[{"name":"From The Miriam Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; Harvard T.H. Chan School of Public Health and Massachusetts General Hospital, Boston, Massachusetts; University of Cincinnati College of Medicine, Cincinnati, Ohio; Johns Hopkins Hospital, Baltimore, Maryland; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama;"},{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; West Virginia University School of Medicine, Morgantown, West Virginia; University of Puerto Rico, San Juan, Puerto Rico; Weill Cornell Medical College, New York, New York; and Gilead Sciences, Foster City, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Ritz","sequence":"additional","affiliation":[{"name":"From The Miriam Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; Harvard T.H. Chan School of Public Health and Massachusetts General Hospital, Boston, Massachusetts; University of Cincinnati College of Medicine, Cincinnati, Ohio; Johns Hopkins Hospital, Baltimore, Maryland; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama;"},{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; West Virginia University School of Medicine, Morgantown, West Virginia; University of Puerto Rico, San Juan, Puerto Rico; Weill Cornell Medical College, New York, New York; and Gilead Sciences, Foster City, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Hodder","sequence":"additional","affiliation":[{"name":"From The Miriam Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; Harvard T.H. Chan School of Public Health and Massachusetts General Hospital, Boston, Massachusetts; University of Cincinnati College of Medicine, Cincinnati, Ohio; Johns Hopkins Hospital, Baltimore, Maryland; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama;"},{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; West Virginia University School of Medicine, Morgantown, West Virginia; University of Puerto Rico, San Juan, Puerto Rico; Weill Cornell Medical College, New York, New York; and Gilead Sciences, Foster City, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge L.","family":"Santana","sequence":"additional","affiliation":[{"name":"From The Miriam Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; Harvard T.H. Chan School of Public Health and Massachusetts General Hospital, Boston, Massachusetts; University of Cincinnati College of Medicine, Cincinnati, Ohio; Johns Hopkins Hospital, Baltimore, Maryland; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama;"},{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; West Virginia University School of Medicine, Morgantown, West Virginia; University of Puerto Rico, San Juan, Puerto Rico; Weill Cornell Medical College, New York, New York; and Gilead Sciences, Foster City, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Wilkin","sequence":"additional","affiliation":[{"name":"From The Miriam Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; Harvard T.H. Chan School of Public Health and Massachusetts General Hospital, Boston, Massachusetts; University of Cincinnati College of Medicine, Cincinnati, Ohio; Johns Hopkins Hospital, Baltimore, Maryland; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama;"},{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; West Virginia University School of Medicine, Morgantown, West Virginia; University of Puerto Rico, San Juan, Puerto Rico; Weill Cornell Medical College, New York, New York; and Gilead Sciences, Foster City, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard H.","family":"Haubrich","sequence":"additional","affiliation":[{"name":"From The Miriam Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; Harvard T.H. Chan School of Public Health and Massachusetts General Hospital, Boston, Massachusetts; University of Cincinnati College of Medicine, Cincinnati, Ohio; Johns Hopkins Hospital, Baltimore, Maryland; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama;"},{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; West Virginia University School of Medicine, Morgantown, West Virginia; University of Puerto Rico, San Juan, Puerto Rico; Weill Cornell Medical College, New York, New York; and Gilead Sciences, Foster City, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the A5241 Study Team","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4285","reference":[{"key":"r2-M150949","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.8722"},{"key":"r3-M150949","doi-asserted-by":"publisher","DOI":"10.1179\/1945577115Y.0000000001"},{"key":"r5-M150949","doi-asserted-by":"publisher","DOI":"10.1310\/hct1005-337"},{"key":"r6-M150949","doi-asserted-by":"publisher","DOI":"10.2174\/1570162X113119990036"},{"key":"r7-M150949","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq432"},{"key":"r8-M150949","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6405-10-33"},{"key":"r9-M150949","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/S0140-6736(13)61164-2","volume":"381","author":"Boyd MA","year":"2013","journal-title":"Lancet"},{"key":"r10-M150949","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311274"},{"key":"r11-M150949","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035026"},{"key":"r12-M150949","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60497-8"},{"key":"r13-M150949","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283316a5e"},{"key":"r14-M150949","doi-asserted-by":"publisher","DOI":"10.1086\/630210"},{"key":"r15-M150949","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000233310.90484.16"},{"key":"r16-M150949","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283365356"},{"key":"r17-M150949","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31827df36c"},{"key":"r18-M150949","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095061"},{"key":"r19-M150949","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1093\/infdis\/jir188","volume":"203","author":"McComsey GA","year":"2011","journal-title":"J Infect Dis"},{"key":"r20-M150949","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit043"},{"key":"r21-M150949","first-page":"382","volume":"22","author":"Sabin CA","year":"2014","journal-title":"Top Antivir Med"}],"container-title":["Annals of Internal Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T13:59:08Z","timestamp":1630936748000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.acpjournals.org\/doi\/10.7326\/M15-0949"}},"subtitle":["A Randomized, Controlled Trial"],"short-title":[],"issued":{"date-parts":[[2015,12,15]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.7326\/M15-0949"],"URL":"https:\/\/doi.org\/10.7326\/m15-0949","relation":{},"ISSN":["0003-4819","1539-3704"],"issn-type":[{"value":"0003-4819","type":"print"},{"value":"1539-3704","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,15]]}}}