{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T17:07:21Z","timestamp":1753895241310,"version":"3.41.2"},"reference-count":0,"publisher":"Wiley","issue":"4S3","license":[{"start":{"date-parts":[[2014,11,2]],"date-time":"2014-11-02T00:00:00Z","timestamp":1414886400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of the International AIDS Society"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>HIV\u20102 infection is endemic in West Africa and some European countries, namely Portugal. HIV\u20102 antiretroviral (ARV) treatment presents some restrains related to intrinsic resistance to non\u2010nucleoside reverse transcriptase inhibitors (NNRTI) and fusion inhibitors, and poorer response to protease inhibitors (PI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Retrospective observational study of a cohort of 135 infected HIV\u20102 patients, diagnosed between 1989 and 2008.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evaluation of epidemiologic, clinical, immunologic and virologic progression, comparing to groups of patients (na\u00efve vs ARV experienced); characterization of therapeutic, immunologic and virologic response. SPSS version 20.0 was used for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 135 patients: 41% (n=55) na\u00efve and 59% (n=80) with ARV experience. The comparison between groups (na\u00efve vs ARV) revealed: male prevalence 76% vs 50%; mean age 54.5 years vs 54.8 (p=0.90); main geographic origin Guin\u00e9 Bissau (47% vs 44%) and Portugal (22% vs 33%); and transmission mainly acquired by heterosexual contact (87% vs 80%). Mean time since diagnosis was 14 vs 13 years (p=0.31); 2% vs 50% presented AIDS criteria at diagnosis (p&lt;0.001) and 93% vs 38% registered TCD4&gt;350 cell\/mm<jats:sup>3<\/jats:sup> at diagnosis (p&lt;0.001). Immunological evolution showed no significant decline in na\u00efve population (\u0394=\u221267 cell\/mm<jats:sup>3<\/jats:sup> \u2013 p=0.18) and a significant recovery in ARV experienced (\u0394=+207 cell\/mm<jats:sup>3<\/jats:sup> \u2013 p&lt;0.001). Global mortality rate found was 18% (6% vs 13% \u2013 p=0.122). Eighty patients initiated ARV: 84% presented a time interval of ARV exposure between 0\u20135 years (42%) and 5\u201310 years (42%). Fifty percent experienced \u22642 ARV regimens and the remaining &gt;2 regimes. Considering the first ARV therapy: 56% initiated PI, 30% NTRI and 5% integrase inhibitor (II)\u2010based regimens. Currently, 54 patients maintain regular follow\u2010up and ARV therapy: 60% NTRI+PI; 37% NRTI+PI+II and 3% NRTI+II. TDF\/FTC is the backbone in 56%. Most frequent PIs are LPV\/r (54%), DRV\/r (19%) and ATV\/r (12%). Mean time of exposure to NRTI=3 years, PI=7 years and II=2 years. Immunologic recovery was sustained for each of the ARV class considered (NRTI \u0394=+144 cell\/mm<jats:sup>3<\/jats:sup>; PI=\u0394+92 cell\/mm<jats:sup>3<\/jats:sup>; II=\u0394=+116 cell\/mm<jats:sup>3<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is a cohort accompanied for a long period and the majority of patients present extensive ARV experience. The ARV\u2010experienced patients registered a favourable response to treatment, with sustained immune recovery (\u0394=+207 cell\/mm<jats:sup>3<\/jats:sup>) and virologic control in 74%. Immunologic behaviour evidenced a sustained gain for each of the ARV class considered.<\/jats:p><\/jats:sec>","DOI":"10.7448\/ias.17.4.19829","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T08:30:34Z","timestamp":1415003434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and laboratorial impact of antiretroviral therapy in a cohort of Portuguese patients chronically infected with HIV\u20102"],"prefix":"10.1002","volume":"17","author":[{"given":"Ana","family":"Miranda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Peres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Moneti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Telma","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Aldir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Mansinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,2]]},"container-title":["Journal of the International AIDS Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.7448%2FIAS.17.4.19829","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.7448\/IAS.17.4.19829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T17:10:03Z","timestamp":1695575403000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.7448\/IAS.17.4.19829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":0,"journal-issue":{"issue":"4S3","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.7448\/IAS.17.4.19829"],"URL":"https:\/\/doi.org\/10.7448\/ias.17.4.19829","archive":["Portico"],"relation":{},"ISSN":["1758-2652","1758-2652"],"issn-type":[{"type":"print","value":"1758-2652"},{"type":"electronic","value":"1758-2652"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"2014-11-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"19829"}}