{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:28:37Z","timestamp":1791347317473,"version":"4.3.1"},"reference-count":125,"publisher":"Wiley","issue":"7S6","license":[{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100011512","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of the International AIDS Society"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>In 2014 the Joint United Nations Programme on HIV\/AIDS defined the ambitious 90\u201390\u201390 targets for 2020, in which 90% of people living with HIV must be diagnosed, 90% of those diagnosed should be on sustained therapy and 90% of those on therapy should have an undetectable viral load. Children are considered to be a key focus population for these targets. This review will highlight key components of the epidemiology, prevention and treatment of tuberculosis (TB) in HIV\u2010infected children in the era of increasing access to antiretroviral therapy (ART) and their relation to the 90\u201390\u201390 targets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The majority of HIV\u2010infected children live in countries with a high burden of TB. In settings with a high burden of both diseases such as in sub\u2010Saharan Africa, up to 57% of children diagnosed with and treated for TB are HIV\u2010infected. TB results in substantial morbidity and mortality in HIV\u2010infected children, so preventing TB and optimizing its treatment in HIV\u2010infected children will be important to ensuring good long\u2010term outcomes. Prevention of TB can be achieved by increasing access to ART to both children and adults, and appropriate provision of isoniazid preventative therapy. Co\u2010treatment of HIV and TB is complicated by drug\u2010drug interactions particularly due to the use of rifampicin; these may compromise virologic outcomes if appropriate corrective actions are not taken. There remain substantial operational challenges, and improved integration of paediatric TB and HIV services, including with antenatal and routine under\u2010five care, is an important priority.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TB may be an important barrier to achievement of the 90\u201390\u201390 targets, but specific attention to TB care in HIV\u2010infected children may provide important opportunities to enhance the care of both TB and HIV in children.<\/jats:p><\/jats:sec>","DOI":"10.7448\/ias.18.7.20236","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T10:53:11Z","timestamp":1449053591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Tuberculosis: opportunities and challenges for the 90\u201390\u201390 targets in HIV\u2010infected children"],"prefix":"10.1002","volume":"18","author":[{"given":"Helena","family":"Rabie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Frigati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke C","family":"Hesseling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J","family":"Garcia\u2010Prats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,2]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organization.Global update on the health sector response to HIV.2014[cited 2015 Feb 13]. Available from:http:\/\/www.who.int\/hiv\/pub\/progressreports\/update2014\u2010executive\u2010summary\/en\/"},{"key":"e_1_2_12_3_1","unstructured":"UNAIDS.90\u201390\u201390 An ambitious treatment target to help end the AIDS epidemic. UNAIDS\/JC2684;2014[cited 2015 Feb 13]. Available from:http:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/90\u201090\u201090_en_0.pdf"},{"key":"e_1_2_12_4_1","unstructured":"World Health Organization. Global tuberculosis report. Contract No.: WHO\/HTM\/TB\/2014.08;2014[cited 2015 Feb 13]. Available from:http:\/\/www.who.int\/tb\/publications\/global_report\/en\/"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70245-1"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-S1-S5"},{"key":"e_1_2_12_7_1","author":"World Health Organization","year":"2014","journal-title":"Guidance for national tuberculosis programmes on the management of tuberculosis in children"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/501018"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/518974"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir605"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jinfdis\/jiq064"},{"issue":"2","key":"e_1_2_12_12_1","first-page":"225","article-title":"Tuberculosis exposure in HIV\u2010exposed infants in a high\u2010prevalence setting","volume":"12","author":"Cotton MF","year":"2008","journal-title":"Int J Tuberc Lung Dis"},{"issue":"5","key":"e_1_2_12_13_1","first-page":"448","article-title":"HIV\u20101 co\u2010infection in children hospitalised with tuberculosis in South Africa","volume":"4","author":"Madhi SA","year":"2000","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/595012"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000223"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31819665c5"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.156752"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0800971"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-8-1"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32835f4fe4"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2008.00559.x"},{"issue":"8","key":"e_1_2_12_22_1","first-page":"700","article-title":"Tuberculosis in human immunodeficiency virus\u2010infected and human immunodeficiency virus\u2010exposed children in New York City","volume":"19","author":"Thomas P","year":"2000","journal-title":"The New York City Pediatric Spectrum of HIV Disease Consortium. Pediatr Infect Dis J"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-305509"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.10.0538"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp208"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2014.08.007"},{"issue":"7","key":"e_1_2_12_27_1","first-page":"862","article-title":"HAART and risk of tuberculosis in HIV\u2010infected South African children: a multi\u2010site retrospective cohort","volume":"13","author":"Martinson NA","year":"2009","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2014.882492"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000226"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.16.1888"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.12.0740"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.13.0395"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835ecb24"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833b260a"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31828d9aa4"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000085"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011214"},{"issue":"9","key":"e_1_2_12_38_1","first-page":"698","article-title":"Efficacy of BCG vaccine in the prevention of tuberculosis","volume":"271","author":"Colditz GA","year":"1994","journal-title":"Meta\u2010analysis of the published literature. JAMA"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.08.055657"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.10.0721"},{"issue":"21","key":"e_1_2_12_41_1","first-page":"193","article-title":"Revised BCG vaccination guidelines for infants at risk for HIV infection","volume":"82","author":"World Health Organization","year":"2007","journal-title":"Wkly Epidemiol Rec."},{"key":"e_1_2_12_42_1","first-page":"1376","article-title":"Consensus statement on the revised World Health Organization recommendations for BCG vaccination in HIV\u2010infected infants","volume":"12","author":"Hesseling AC","year":"2008","journal-title":"Int J Tuberc Lung Dis"},{"issue":"2","key":"e_1_2_12_43_1","first-page":"88","article-title":"BCG vaccination in South African HIV\u2010exposed infants\u2013risks and benefits","volume":"99","author":"Hesseling AC","year":"2009","journal-title":"S Afr Med J"},{"issue":"4","key":"e_1_2_12_44_1","first-page":"392","article-title":"The natural history of childhood intra\u2010thoracic tuberculosis: a critical review of literature from the pre\u2010chemotherapy era","volume":"8","author":"Marais BJ","year":"2004","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196709142771103"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1974.03230430020019"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39000.486400.55"},{"issue":"5","key":"e_1_2_12_48_1","first-page":"650","article-title":"Recording isoniazid preventive therapy delivery to children: operational challenges","volume":"14","author":"Van Wyk SS","year":"2010","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-7"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080803"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-281"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ebch.1962"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.3158"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60204-3"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.10.0795"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091464"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181eaefff"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01658-08"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01868-13"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083750"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214901"},{"key":"e_1_2_12_62_1","first-page":"806","article-title":"Tuberculosis in children dying with HIV\u2010related lung disease: clinical\u2010 pathological correlations","volume":"6","author":"Rennert WP","year":"2002","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017273"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1086\/651454"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833f9e04"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000544"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318279c800"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.3710"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055111"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62198-9"},{"key":"e_1_2_12_71_1","author":"World Health Organization","year":"2010","journal-title":"Rapid advice. Treatment of tuberculosis in children. WHO\/HTM\/TB\/2010.13"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.08.056804"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05429-11"},{"issue":"4","key":"e_1_2_12_74_1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/jac\/dku478","article-title":"Subtherapeutic concentrations of first\u2010line anti\u2010TB drugs in South African children treated according to current guidelines: the PHATISA study","volume":"70","author":"Hiruy H","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000336"},{"issue":"12","key":"e_1_2_12_76_1","first-page":"1318","article-title":"Ethambutol dosage for the treatment of children: literature review and recommendations","volume":"10","author":"Donald PR","year":"2006","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000589"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2011.11.001"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02755-13"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu868"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328326ca50"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03073-14"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.10.0707"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.12.0322"},{"key":"e_1_2_12_85_1","author":"World Health Organization","year":"2013","journal-title":"The use of bedaquiline in the treatment of multidrug resistant tuberculosis. Interim policy guidance. WHO\/HTM\/TB\/ 2013.6"},{"key":"e_1_2_12_86_1","author":"World Health Organization","year":"2014","journal-title":"The use of delamanid in the treatment of multidrug\u2010resistant tuberculosis: interim policy guidance"},{"issue":"4","key":"e_1_2_12_87_1","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1093\/jac\/dku504","article-title":"Rifampicin and rifapentine significantly reduce concentrations of bedaquiline, a new anti\u2010TB drug","volume":"70","author":"Svensson EM","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03246-14"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00191-13"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113249"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000931"},{"key":"e_1_2_12_92_1","author":"World Health Organization","year":"2013","journal-title":"Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1455"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181642257"},{"key":"e_1_2_12_95_1","volume-title":"Interim analysis of an open label sequential nonrandomized pharmakinetics study","author":"Rabie HDP","year":"2015"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01598-10"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1757"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12101"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku382"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00461-06"},{"issue":"4","key":"e_1_2_12_101_1","doi-asserted-by":"crossref","first-page":"19586","DOI":"10.7448\/IAS.17.4.19586","article-title":"Simulation of the impact of rifampicin on darunavir\/ritonavir PK and dose adjustment strategies in HIV\u2010infected patients: a population PK approach","volume":"17","author":"Dickinson L","year":"2014","journal-title":"J Int AIDS Soci"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31819c33a3"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328360dbb4"},{"key":"e_1_2_12_104_1","author":"Panel on Antiretroviral Guidelines for Adults and Adolescents","year":"2015","journal-title":"Guidelines for the use of antiretroviral agents in HIV\u20101\u2010infected adults and adolescents. Department of Health and Human Services"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182401c41"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283550e20"},{"key":"e_1_2_12_107_1","volume-title":"Conference of Retrovirology and Opportunistic Infection","author":"Barlow\u2010Mosha L","year":"2009"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283620811"},{"key":"e_1_2_12_109_1","volume-title":"Effects of maternal tuberculosis treatment on nevirapine concentrations among neonates receiving nevirapine for prevention of mother to\u2010child transmission of HIV international AIDS Society Conference","author":"McIlleron HDP","year":"2013"},{"key":"e_1_2_12_110_1","volume-title":"21st Conference on Retroviruses and Opportunistic Infections","author":"Coovadia A"},{"issue":"4","key":"e_1_2_12_111_1","first-page":"775","article-title":"Pharmacokinetics of etravirine in HIV\u2010infected patients concomitantly treated with rifampin for tuberculosis","volume":"42","author":"Gagliardini R","year":"2014","journal-title":"Infection"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01468-08"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)11467-8"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905848"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328339e576"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-013-0378-5"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2012.04.005"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1353"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir772"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.14.0231"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-28"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit655"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203900"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.15.0123"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.14.0106"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis009"}],"container-title":["Journal of the International AIDS Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.7448%2FIAS.18.7.20236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.7448\/IAS.18.7.20236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:29:25Z","timestamp":1695554965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.7448\/IAS.18.7.20236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":125,"journal-issue":{"issue":"7S6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.7448\/IAS.18.7.20236"],"URL":"https:\/\/doi.org\/10.7448\/ias.18.7.20236","archive":["Portico"],"relation":{},"ISSN":["1758-2652","1758-2652"],"issn-type":[{"value":"1758-2652","type":"print"},{"value":"1758-2652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"2015-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"20236"}}