{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:42:53Z","timestamp":1769820173366,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":294,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100001117","name":"amfAR, The Foundation for AIDS Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001117","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of the International AIDS Society"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Outbreaks of syphilis have been described among HIV\u2010infected men who have sex with men (MSM) in Western communities, whereas reports in Asian countries are limited. We aimed to characterize the incidence and temporal trends of syphilis among HIV\u2010infected MSM compared with HIV\u2010infected non\u2010MSM in Asian countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients enrolled in the TREAT Asia HIV Observational Database cohort and with a negative non\u2010treponemal test since enrolment were analyzed. Incidence of syphilis seroconversion, defined as a positive non\u2010treponemal test after previously testing negative, was evaluated among patients at sites performing non\u2010treponemal tests at least annually. Factors associated with syphilis seroconversion were investigated at sites doing non\u2010treponemal testing in all new patients and subsequently testing routinely or when patients were suspected of having syphilis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 1010 patients from five sites that performed non\u2010treponemal tests in all new patients; those included had negative non\u2010treponemal test results during enrolment and subsequent follow\u2010ups. Among them, 657 patients were from three sites conducting regular non\u2010treponemal testing. The incidence of syphilis seroconversion was 5.38\/100 person\u2010years (PY). Incidence was higher in MSM than non\u2010MSM (7.64\/100 PY vs. 2.44\/100 PY, <jats:italic>p&lt;<\/jats:italic>0.001). Among MSM, the incidence rate ratio (IRR) for every additional year from 2009 was 1.19 (<jats:italic>p=<\/jats:italic>0.051). MSM status (IRR 3.48, 95% confidence interval (CI) 1.88\u20136.47), past syphilis diagnosis (IRR 5.15, 95% CI 3.69\u20137.17) and younger age (IRR 0.84 for every additional 10 years, 95% CI 0.706\u20130.997) were significantly associated with syphilis seroconversion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed a higher incidence of syphilis seroconversion among HIV\u2010infected MSM and a trend to increasing annual incidence. Regular screening for syphilis and targeted interventions to limit transmission are needed in this population.<\/jats:p><\/jats:sec>","DOI":"10.7448\/ias.19.1.20965","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T10:11:54Z","timestamp":1477044714000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Incidence of syphilis seroconversion among HIV\u2010infected persons in Asia: results from the TREAT Asia HIV Observational Database"],"prefix":"10.1002","volume":"19","author":[{"given":"Jin Young","family":"Ahn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Boettiger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasisopin","family":"Kiertiburanakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuti Parwati","family":"Merati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui Vu","family":"Huy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing Wai","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"Ditangco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man Po","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Oka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Durier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Yong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Treat Asia HIV Observational Database","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,21]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Centers for Disease Control and Prevention.Sexually transmitted disease surveillance 2014 [Internet].2015[cited 2015 Nov 1]. 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