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Finding ways to increase HIV testing and PrEP uptake among high\u2010risk groups is a critical priority. This study evaluates the effect of a novel Adam's Love Online\u2010to\u2010Offline (O2O) model on PrEP and HIV testing uptake among Thai MSM and TG and identifies factors associated with PrEP uptake.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : The O2O model was piloted by Adam's Love (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.adamslove.org\">www.adamslove.org<\/jats:ext-link>\n                    ) HIV educational and counselling website. MSM and TG reached online by PrEP promotions and interested in free PrEP and\/or HIV testing services contacted Adam's Love online staff, received real\u2010time PrEP eCounseling, and completed online bookings for receiving services at one of the four sites in Bangkok based on their preference. Auto\u2010generated site\u2010 and service\u2010specific e\u2010tickets and Quick Response (QR) codes were sent to their mobile devices enabling monitoring and check\u2010in by offline site staff. Service uptake and participant's socio\u2010demographic and risk behaviour characteristics were analyzed. Factors associated with PrEP uptake were assessed using multiple logistic regression.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : Between January 10th and April 11th, 2016, Adam's Love reached 272,568 people online via the PrEP O2O promotions. 425 MSM and TG received eCounseling and e\u2010tickets. There were 325 (76.5%) MSM and TG who checked\u2010in at clinics and received HIV testing. Nine (2.8%) were diagnosed with HIV infection. Median (IQR) time between receiving the e\u2010ticket and checking\u2010in was 3 (0\u20137) days. Of 316 HIV\u2010negative MSM and TG, 168 (53.2%) started PrEP. In a multivariate model, higher education (OR 2.30, 95%CI 1.14\u20134.66;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.02), seeking sex partners online (OR 2.05, 95%CI 1.19\u20133.54;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.009), being aware of sexual partners\u2019 HIV status (OR 2.37, 95%CI 1.29\u20134.35;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.008), ever previously using post\u2010exposure prophylaxis (PEP) (OR 2.46, 95%CI 1.19\u20135.09;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.01), and enrolment at Adam's Love clinic compared to the other three sites (OR 3.79, 95%CI 2.06\u20136.95;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) were independently associated with PrEP uptake.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : Adam's Love O2O model is highly effective in linking online at\u2010risk MSM and TG to PrEP and HIV testing services, and has high potential to be replicated and scaled up in other settings with high Internet penetration among key populations.\n                  <\/jats:p>","DOI":"10.7448\/ias.20.1.21326","type":"journal-article","created":{"date-parts":[[2017,3,18]],"date-time":"2017-03-18T20:31:52Z","timestamp":1489869112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["A novel Online\u2010to\u2010Offline (O2O) model for pre\u2010exposure prophylaxis and HIV testing scale up"],"prefix":"10.1002","volume":"20","author":[{"given":"Tarandeep","family":"Anand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chattiya","family":"Nitpolprasert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deondara","family":"Trachunthong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surang","family":"Janyam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danai","family":"Linjongrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa B","family":"Hightow\u2010Weidman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praphan","family":"Phanuphak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintanat","family":"Ananworanich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nittaya","family":"Phanuphak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Adam's Love study team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181c2fc86"},{"issue":"25","key":"e_1_2_12_3_1","first-page":"518","article-title":"HIV and syphilis infection among men who have sex with men \u2013 Bangkok, 2005\u20132011","volume":"62","author":"Ananworanich J","year":"2013","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2011.597709"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-010-9850-5"},{"key":"e_1_2_12_6_1","unstructured":"National AIDS Committee. 2012 Thailand AIDS response progress: status at a glance. 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