{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T23:48:51Z","timestamp":1783554531930,"version":"3.55.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":164,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"KVW"},{"name":"South African National Research Foundation (Free-Standing NRF Doctoral Scholarship)"},{"name":"University of Cape Town (UCT Doctoral Scholarship)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of the International AIDS Society"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Introduction<\/jats:bold>: Despite improved efficacy of, and access to, combination antiretroviral therapy (cART), HIV\u2010associated cognitive impairments remain prevalent in both children and adults. Neuropsychological tests that detect such impairment can help clinicians formulate effective treatment plans. The Kaufman Assessment Battery for Children (KABC), although developed and standardized in the United States, is used frequently in many different countries and cultural contexts to assess paediatric performance across various cognitive domains. This systematic review investigated the cross\u2010cultural utility of the original KABC, and its 2nd edition (KABC\u2010II), in detecting HIV\u2010associated cognitive impairment in children and adolescents.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>: We entered relevant keywords and MeSH terms into the PubMed, PsycInfo, EBSCOHost, ProQuest, and Scopus databases, with search limits set from 1983\u20132017. Two independent reviewers evaluated the retrieved abstracts and manuscripts. Studies eligible for inclusion in the review were those that (a) used the KABC\/KABC\u2010II to assess cognitive function in children\/adolescents aged 2\u201318\u00a0years, (b) featured a definition of cognitive impairment (e.g. &gt;2 SD below the mean) or compared the performance of HIV\u2010infected and uninfected control groups, and (c) used a sample excluded from population on which the instruments were normed.<\/jats:p><jats:p><jats:bold>Results and discussion<\/jats:bold>: We identified nine studies (eight conducted in African countries, and one in the United Kingdom) to comprise the review's sample. All studies detected cognitive impairment in HIV\u2010infected children, including those who were cART\u2010na\u00efve or who were cART treated and clinically stable. KABC\/KABC\u2010II subtests assessing simultaneous processing appeared most sensitive. Evaluation of the methodological quality of the selected studies by two independent reviews suggested that shortcomings included reporting and selection biases.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold>: This systematic review provides evidence for the cross\u2010cultural utility of the KABC\/KABC\u2010II, particularly the simultaneous processing subtests, in detecting cognitive impairment in HIV\u2010infected children (including those who are clinically stable). Although the current results suggest there is justification for using the KABC\/KABC\u2010II primarily in East Africa, further investigation is required to explore the instrument's utility in other HIV\u2010prevalent regions of the globe.<\/jats:p>","DOI":"10.7448\/ias.20.1.21412","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T16:27:31Z","timestamp":1498580851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Cross\u2010cultural assessment of HIV\u2010associated cognitive impairment using the Kaufman assessment battery for children: a systematic review"],"prefix":"10.1002","volume":"20","author":[{"given":"Kaylee S","family":"van Wyhe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"van de Water","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Boivin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark F","family":"Cotton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin GF","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"UNAIDS.The gap report. 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