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ASD is characterized by impaired communication and social interaction and may involve developmental delays and seizure disorders. Recent parent-reported diagnosis of ASD in the United States put it at higher levels (1:91) than previously thought, with its diagnosis in boys occurring 4 to 5 times more frequently than in girls (1:58).\n                    <jats:sup>1<\/jats:sup>\n                    CDC estimates are currently 1:110;\n                    <jats:sup>1<\/jats:sup>\n                    up from 1:150 in 2007.\n                    <jats:sup>2<\/jats:sup>\n                    Annual medical expenditures for those affected are generally four to six times greater than for those without ASD.\n                    <jats:sup>1<\/jats:sup>\n                    While twin studies demonstrate that genetics play a significant role in ASD, the impact of environment should not be underestimated, given the approximate 20-fold increase in incidence over the last 20 years.\n                    <jats:sup>3<\/jats:sup>\n                  <\/jats:p>","DOI":"10.7453\/gahmj.2012.1.4.010","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T21:21:29Z","timestamp":1349126489000},"page":"62-74","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Autism Spectrum Disorders"],"prefix":"10.1177","volume":"1","author":[{"given":"Kara","family":"Fitzgerald","sequence":"first","affiliation":[{"name":"Institute for Functional Medicine, Gig Harbor, Washington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hyman","sequence":"additional","affiliation":[{"name":"Institute for Functional Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hyman","sequence":"additional","affiliation":[{"name":"Institute for Functional Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathie","family":"Swift","sequence":"additional","affiliation":[{"name":"Optimal Health and Prevention Research Foundation in San Diego, California. UltraWellness Center, in Lenox, Massachusetts, and the Kripalu Center for Yoga and Health, in Stockbridge, Massachusetts, Saybrook University, San Francisco, California."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,9,1]]},"reference":[{"key":"bibr1-gahmj.2012.1.4.010","unstructured":"CDC. Autism Spectrum Disorders. http:\/\/www.cdc.gov\/ncbddd\/autism\/data.html. Accessed 5\/15\/2010, 2010."},{"key":"bibr2-gahmj.2012.1.4.010","unstructured":"CDC. Prevalence of Autism Spectrum Disorders \u2014 Autism and Developmental Disabilities Monitoring Network, 14 Sites, United States, 2002. MMWR [http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/ss5601a2.htm. 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