{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:05:33Z","timestamp":1791331533455,"version":"4.3.1"},"reference-count":31,"publisher":"MDPI AG","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3]]},"abstract":"\n Background<\/jats:title>\n Regarding antibiotic-loaded cements, there is an abundant amount of literature regarding the antibacterial in vitro inhibitory and clinical applications for the treatment of osteomyelitis. The opposite can be said about literature regarding in vitro antifungal-loaded cement drug delivery for the treatment of fungal osteomyelitis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Aspergillus fumigatus<\/jats:italic>\n and\n Candida<\/jats:italic>\n (ATCC 1023ATCC, Manassas, Virginia) were plated on antibiotic\/antifungal-free plates. Voriconazole- and amphotericin B\u2013impregnated calcium sulfate and hydroxyapatite (HA) disks, calcium sulfate + HA control disks, and control polymethylmethacrylate disks were laid separately onto plates separately inoculated with\n Aspergillus<\/jats:italic>\n and\n Candida<\/jats:italic>\n spp. The zones of inhibition obtained were measured in millimeters at 24, 36, and 96 hours.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Etest (bioM\u00e9rieux, Marcy l'Etoile, France) results demonstrated susceptibility of\n Aspergillus<\/jats:italic>\n and\n Candida<\/jats:italic>\n to amphotericin B and voriconazole. The zone of inhibition data demonstrated that voriconazole and amphotericin B retained their antifungal activity when mixed into the calcium sulfate + HA bone void filler and eluted at biologically effective antifungal concentrations over 96 hours.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The calcium sulfate + HA bone void filler is a biocompatible ceramic carrier vehicle that can successfully deliver the antifungal drugs voriconazole and amphotericin B in the adjunctive treatment of fungal osteomyelitis. It is a reliable strategy in the local delivery of antifungal drugs to an area of osteomyelitis.<\/jats:p>\n <\/jats:sec>","DOI":"10.7547\/0003-0538-105.2.104","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T11:27:21Z","timestamp":1427455641000},"page":"104-110","source":"Crossref","is-referenced-by-count":9,"title":["In Vitro Activity of Calcium Sulfate and Hydroxyapatite Antifungal Disks Loaded with Amphotericin B or Voriconazole in Consideration for Adjunctive Osteomyelitis Management"],"prefix":"10.3390","volume":"105","author":[{"given":"Jeffrey C.","family":"Karr","sequence":"first","affiliation":[{"name":"Lakeland Regional Medical Center, Lakeland, FL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Lauretta","sequence":"additional","affiliation":[{"name":"Lakeland Regional Medical Center, Lakeland, FL."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"i8750-7315-105-2-104-b01","series-title":"Chirurg","first-page":"511","article-title":"Uber die depotwirkung einiger antibiotica bei vermischung mit dem kunstharz palacos","volume":"41","author":"Buchholz\n HW,","year":"1970","unstructured":"Buchholz\n HW, \n \n Engelbrecht\n H:\n \n \n Uber die depotwirkung einiger antibiotica bei vermischung mit dem kunstharz palacos. 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