{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:17:18Z","timestamp":1783430238465,"version":"3.54.6"},"reference-count":7,"publisher":"MDPI AG","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPMA"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>We describe the management of a patient who presented to a family-practice clinic with gangrenous digits. After a thorough evaluation, she was found to have protein C deficiency, which produced a hypercoagulable state. Differential diagnosis in the evaluation of the coagulopathic patient with appropriate hematologic tests is briefly discussed. (J Am Podiatr Med Assoc 95(5): 491\u2013493, 2005)<\/jats:p>","DOI":"10.7547\/0950491","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T10:26:49Z","timestamp":1396348009000},"page":"491-493","source":"Crossref","is-referenced-by-count":0,"title":["Protein C Deficiency"],"prefix":"10.3390","volume":"95","author":[{"given":"Travis A.","family":"Motley","sequence":"first","affiliation":[{"name":"Podiatry Section, Department of Orthopaedics, John Peter Smith Hospital, Fort Worth, TX."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clint L.","family":"Vanlandingham","sequence":"additional","affiliation":[{"name":"Podiatry Residency Program, Kern Hospital, Warren, MI. Dr. Vanlandingham is now in private practice, Poplar Bluff, MO."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"R1","series-title":"Semin Thromb Hemost","first-page":"265","volume":"25","year":"1999","unstructured":"Nizzi FA Jr, Kaplan HS: Protein C and S deficiency. .Semin Thromb Hemost25::265. ,1999. .10443958"},{"key":"R2","series-title":"Am J Med","first-page":"414","volume":"110","year":"2001","unstructured":"Sadiq A, Ahmed S, Karim A, et al: Acute myocardial infarction: a rare complication of protein C deficiency. .Am J Med110::414. ,2001. ."},{"key":"R3","series-title":"Am J Hematol","first-page":"44","volume":"62","year":"1999","unstructured":"Warkentin TE, Sikov WM, Lillicrap DP: Multicentric warfarin-induced skin necrosis complicating heparin-induced thrombocytopenia. .Am J Hematol62::44. ,1999. .10467275"},{"key":"R4","series-title":"Ann Plast Surg","first-page":"194","volume":"41","year":"1998","unstructured":"Huseyin B, Dogan T, Anil A, et al: Progressive gangrene of the hand following extravasation of antibiotics associated with hereditary resistance to activated protein C. .Ann Plast Surg41::194. ,1998. .9718155"},{"key":"R5","series-title":"Mayo Clin Proc","first-page":"319","volume":"76","year":"2001","unstructured":"Onwuanyi A, Sachdeva R, Hamirani K, et al: Multiple aortic thrombi associated with protein C and S deficiency. .Mayo Clin Proc76::319. ,2001. .11243280"},{"key":"R6","series-title":"Br J Radiol","first-page":"843","volume":"75","year":"2002","unstructured":"Cho YP, Lee DH, Jang HJ, et al: Peripheral arterial insufficiency associated with protein C deficiency. .Br J Radiol75::843. ,2002. .12381694"},{"key":"R7","year":"1999","unstructured":"Adler SN, Adler-Klein D, Gasbarra DB: \u201cHematologic System,\u201d in Pocket Manual of Differential Diagnosis, 4th Ed, p 223, Lippincott Williams & Wilkins, Philadelphia. ,1999. ."}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/95\/5\/0950491.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/japma\/article-pdf\/95\/5\/491\/1417340\/0950491.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/95\/5\/0950491.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/95\/5\/0950491.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:46:10Z","timestamp":1783428370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/95\/5\/491"}},"subtitle":["Podiatric Medical Relevance and Case Report"],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":7,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.7547\/0950491","relation":{},"ISSN":["8750-7315","1930-8264"],"issn-type":[{"value":"8750-7315","type":"print"},{"value":"1930-8264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}