{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:21:59Z","timestamp":1783506119622,"version":"3.55.0"},"reference-count":9,"publisher":"MDPI AG","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPMA"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p>Hyperhidrosis is defined as excessive and uncontrollable sweating due to overactivity of the eccrine sweat glands. The first line of treatment for plantar hyperhidrosis consists of conservative therapies such as topical solutions (ie, antiperspirant applications and aluminum chloride preparations) and iontophoresis. When the patient has failed these standard treatments, the other available medical options are rather limited and not well tolerated. Botulinum toxin type A (Botox, Allergan Inc, Irvine, California) is a purified neurotoxin complex approved by the US Food and Drug Administration in 2004 for multiple medical conditions, including severe primary axillary hyperhidrosis that failed conservative topical therapies. Few recent clinical studies have suggested that botulinum toxin is effective in the treatment of plantar hyperhidrosis. In this case study, two patients received intradermal injections of botulinum toxin type A into the plantar aspect of both feet. A 3-month follow-up evaluated the efficacy of botulinum toxin type A by subjectively assessing the amount of residual sweating. In these two patients, botulinum toxin type A was an effective and safe treatment for plantar hyperhidrosis. 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Patrick","family":"Dunn","sequence":"additional","affiliation":[{"name":"Temple University School of Podiatric Medicine, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill C.","family":"Blau","sequence":"additional","affiliation":[{"name":"Virtua Health Systems, Camden, NJ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Cambridge Health Alliance, Cambridge, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"R1","series-title":"Dermatol Surg","first-page":"S69","volume":"33","year":"2007","unstructured":"Lear W, Kessler E, Solish N, et al: An epidemiological study of hyperhidrosis. .Dermatol Surg33::S69. ,2007. .17241417"},{"key":"R2","series-title":"Dermatol Surg","first-page":"822","volume":"28","year":"2002","unstructured":"Lowe NJ, Yamauchi PS, Lask GP, et al: Efficacy and safety of botulinum toxin type a in the treatment of palmar hyperhidrosis: a double blind, randomized, placebo-controlled study. .Dermatol Surg28::822. ,2002. .12269876"},{"key":"R3","series-title":"Int J Dermatol","first-page":"969","volume":"43","year":"2004","unstructured":"Vadoud-Seyedi, J: Treatment of plantar hyperhidrosis with botulinum toxin type A. .Int J Dermatol43::969. ,2004. .15569036"},{"key":"R4","series-title":"Neurosurgery","first-page":"110","volume":"41","year":"1997","unstructured":"Lai YT, Yang LH, Chio CC, et al: Complications in patients with palmar hyperhidrosis with transthoracic endoscopic sympathectomy. .Neurosurgery41::110. ,1997. .9218302"},{"key":"R5","series-title":"Neurology","first-page":"2095","volume":"57","year":"2001","unstructured":"Saadia D, Voustianiouk A, Wang AK, et al: Botulinum toxin type A in primary palmar hyperhidrosis. .Neurology57::2095. ,2001. .11739832"},{"key":"R6","series-title":"Acta Neurol Belg","first-page":"167","volume":"102","year":"2002","unstructured":"Sevim S, Dogu O, Kaleagasi H: Botulinum toxin-A therapy for palmar and plantar hyperhidrosis. .Acta Neurol Belg102::167. ,2002. .12534243"},{"key":"R7","series-title":"J Cosm Derm","first-page":"163","volume":"4","year":"2005","unstructured":"Perez-Bernal A, Avalos-Peralta P, Moreno-Ramirez D, et al: Treatment of palmar hyperhidrosis with botulinum toxin type A : 44 months of experience. .J Cosm Derm4::163. ,2005. ."},{"key":"R8","series-title":"Br Med J","first-page":"596","volume":"323","year":"2001","unstructured":"Naumann M, Lowe NJ: Botulinum toxin type A in treatment of bilateral primary axillary hyperhidrosis: randomised, parallel group, double blind, placebo controlled trial. .Br Med J323::596. ,2001. ."},{"key":"R9","series-title":"Dermatol Surg","first-page":"S88","volume":"33","year":"2007","unstructured":"Smith KC, Comite SL, and Storwick GL: Ice minimizes discomfort associated with injection of botulinum toxin type A for the treatment of palmar and plantar hyperhidrosis. .Dermatol Surg33::S88. ,2007. .17241420"}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/98\/2\/0980156.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/japma\/article-pdf\/98\/2\/156\/1412006\/0980156.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/98\/2\/0980156.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/98\/2\/0980156.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:11:19Z","timestamp":1783505479000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/98\/2\/156"}},"subtitle":["A Case Study"],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":9,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.7547\/0980156","relation":{},"ISSN":["8750-7315","1930-8264"],"issn-type":[{"value":"8750-7315","type":"print"},{"value":"1930-8264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}