{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:22:15Z","timestamp":1783506135697,"version":"3.55.0"},"reference-count":11,"publisher":"MDPI AG","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPMA"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>Stevens-Johnson syndrome and toxic epidermal necrolysis are rare; however, when they occur, they usually present with severe reactions in response to medications and other stimuli. These reactions are characterized by mucocutaneous lesions, which ultimately lead to epidermal death and sloughing. We present a unique case report of Stevens-Johnson syndrome and associated toxic epidermal necrolysis in a 61-year-old man after treatment for a peripherally inserted central catheter infection with trimethoprim-sulfamethoxazole. This case report reviews a rare adverse reaction to a commonly prescribed antibiotic drug used in podiatric medical practice for the management of diabetic foot infections. (J Am Podiatr Med Assoc 100(4): 299\u2013303, 2010)<\/jats:p>","DOI":"10.7547\/1000299","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T09:54:57Z","timestamp":1396346097000},"page":"299-303","source":"Crossref","is-referenced-by-count":10,"title":["Trimethoprim-Sulfamethoxazole\u2013Induced Stevens-Johnson Syndrome"],"prefix":"10.3390","volume":"100","author":[{"given":"Michael R.","family":"Langlois","sequence":"first","affiliation":[{"name":"Orthopaedics\/Division of Podiatric Medicine and Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, TX."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Derk","sequence":"additional","affiliation":[{"name":"Surgery, Audie L. Murphy VA Hospital, San Antonio, TX."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Belczyk","sequence":"additional","affiliation":[{"name":"Orthopaedics\/Division of Podiatric Medicine and Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, TX."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Zgonis","sequence":"additional","affiliation":[{"name":"Orthopaedics\/Division of Podiatric Medicine and Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, TX."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"R1","series-title":"Vital Health Stat 13","first-page":"1","volume":"163","year":"2006","unstructured":"Raofi S, Shappert SM: Medication therapy in ambulatory medical care: United States, 2003\u201304. .Vital Health Stat 13163::1. ,2006. ."},{"key":"R2","series-title":"Clin Ther","first-page":"1503","volume":"25","year":"2003","unstructured":"Ma J, Stafford RS, Cockburn IM, et al: A statistical analysis of the magnitude and composition of drug promotion in the United States in 1998. .Clin Ther25::1503. ,2003. .12867225"},{"key":"R3","series-title":"Clin Infect Dis","first-page":"735","volume":"47","year":"2008","unstructured":"Shehab N, Patel PR, Srinivasan A, et al: Emergency department visits for antibiotic-associated adverse events. .Clin Infect Dis47::735. ,2008. .18694344"},{"key":"R4","year":"2005","unstructured":"Sylvia LM: \u201cDrug Allergy and Pseudoallergy,\u201d in Drug-Induced Diseases: Prevention, Detection, and Management, Vol 1, ed by JE Tisdale, DA Miller, p 27, American Society of Health-System Pharmacists, Bethesda, MD. ,2005. ."},{"key":"R5","series-title":"Arch Dermatol","first-page":"323","volume":"136","year":"2000","unstructured":"Garcia-Doval I, Lecleach L, Bocquet H, et al: Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of drugs decrease the risk of death?. 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