{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:37:46Z","timestamp":1785242266888,"version":"3.55.0"},"reference-count":34,"publisher":"MDPI AG","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This randomized, prospective, multicenter, open-label study was designed to test whether a topical, electrolyzed, superoxidized solution (Microcyn Rx) is a safe and effective treatment for mildly infected diabetic foot ulcers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Sixty-seven patients with ulcers were randomized into three groups. Patients with wounds irrigated with Microcyn Rx alone were compared with patients treated with oral levofloxacin plus normal saline wound irrigation and with patients treated with oral levofloxacin plus Microcyn Rx wound irrigation. Patients were evaluated on day 3, at the end of treatment on day 10 (visit 3), and 14 days after completion of therapy for test of cure (visit 4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the intention-to-treat sample at visit 3, the clinical success rate was higher in the Microcyn Rx alone group (75.0%) than in the saline plus levofloxacin group (57.1%) or in the Microcyn Rx plus levofloxacin group (64.0%). Results at visit 4 were similar. In the clinically evaluable population, the clinical success rate at visit 3 (end of treatment) for patients treated with Microcyn Rx alone was 77.8% versus 61.1% for the levofloxacin group. The clinical success rate at visit 4 (test of cure) for patients treated with Microcyn Rx alone was 93.3% versus 56.3% for levofloxacin plus saline\u2013treated patients. This study was not statistically powered, but the high clinical success rate (93.3%) and the P value (P = .033) suggest that the difference is meaningfully positive for Microcyn Rx\u2013treated patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Microcyn Rx is safe and at least as effective as oral levofloxacin for mild diabetic foot infections. (J Am Podiatr Med Assoc 101(6): 484\u2013496, 2011)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7547\/1010484","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T09:47:33Z","timestamp":1396345653000},"page":"484-496","source":"Crossref","is-referenced-by-count":27,"title":["An Open-label, Three-arm Pilot Study of the Safety and Efficacy of Topical Microcyn Rx Wound Care versus Oral Levofloxacin versus Combined Therapy for Mild Diabetic Foot Infections"],"prefix":"10.3390","volume":"101","author":[{"given":"Adam","family":"Landsman","sequence":"first","affiliation":[{"name":"Podiatric Surgery, Harvard Medical School\/Cambridge Health Alliance, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Blume","sequence":"first","affiliation":[{"name":"Surgery, Orthopedics, and Rehabilitation, Yale School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Douglas A.","family":"Jordan","sequence":"first","affiliation":[{"name":"Clinical Research of Tampa Bay, Port Richey, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Vayser","sequence":"first","affiliation":[{"name":"Scripps, San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Gutierrez","sequence":"first","affiliation":[{"name":"Oculus Innovative Sciences, Petaluma, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"ref11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1464-5491.2006.01785.x","article-title":"Systematic review of antimicrobial treatments for diabetic foot ulcers.","volume":"23","author":"Nelson","year":"2006","journal-title":"Diabet Med"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/00005373-200009000-00020","article-title":"Effectiveness of hydrolyzed water irrigation in a burn-wound infection model.","volume":"49","author":"Nakae","year":"2000","journal-title":"J Trauma"},{"key":"ref91","first-page":"11","article-title":"Advanced wound care with stable super-oxidized water: a look at how combination therapy can optimize wound healing.","volume":"18","author":"Wolvos","year":"2006","journal-title":"Wounds Compend Clin Res Pract"},{"key":"ref331","first-page":"262","article-title":"Super-oxidized solution (SOS) therapy for infected diabetic foot ulcers.","volume":"18","author":"Dalla-Paola","year":"2006","journal-title":"Wounds Compend Clin Res Pract"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2337\/diacare.21.5.855","article-title":"Validation of a diabetic wound classification system: the contribution of depth, infection, and ischemia to risk of amputation.","volume":"21","author":"Armstrong","year":"1998","journal-title":"Diabet Care"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s005950070035","article-title":"Mediastinal irrigation with superoxidized water after open-heart surgery: the safety and pitfalls of cardiovascular surgical application.","volume":"30","author":"Ohno","year":"2000","journal-title":"Surg Today"},{"key":"ref291","first-page":"201","article-title":"Use of Microcyn Rx, a new antiseptic agent for the treatment of diabetic foot ulcers.","volume":"2","author":"Dalla-Paola","year":"2005","journal-title":"J Wound Healing"},{"key":"ref131","first-page":"740","article-title":"Treating infected diabetic wounds with superoxidized water as anti-septic agent: a preliminary experience.","volume":"17","author":"Hadi","year":"2007","journal-title":"J Coll Phys Surg Pak"},{"key":"ref101","first-page":"3","article-title":"Super-oxidized Microcyn technology in lower-extremity 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Infect"},{"key":"ref271","first-page":"11","article-title":"Advanced wound care with stable super-oxidized water: a look at how combination therapy can optimize wound healing.","volume":"18","author":"Wolvos","year":"2006","journal-title":"Wounds Compend Clin Res Pract"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4012\/dmj.21.93","article-title":"Durability of bactericidal activity in electrolyzed neutral water by storage.","volume":"21","author":"Nagamatsu","year":"2002","journal-title":"Dent Mater J"},{"key":"ref21","first-page":"S97","article-title":"An appraisal of povidone-iodine and wound healing.","volume":"69","author":"Goldenheim","year":"1993","journal-title":"Postgrad Med J"},{"key":"ref31","first-page":"7","article-title":"The science behind stable, super-oxidized water: exploring the various applications of super-oxidized solutions.","volume":"18","author":"Gutierrez","year":"2006","journal-title":"Wounds Compend Clin Res 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