{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:22:30Z","timestamp":1783506150543,"version":"3.55.0"},"reference-count":24,"publisher":"MDPI AG","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Am Podiatr Med Assoc"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>Nephrogenic systemic fibrosis (NSF) is a severely debilitating disease that was first described in the literature by Cowper and colleagues in 2000. It is pertinent to the field of podiatry because patients with NSF first manifest cutaneous symptoms in the lower extremity in the form of fibrosing lesions. To date, these lesions have been documented only in people with moderate to severe kidney failure. There is speculation that gadolinium, used as a contrast agent for imaging, might be the inciting factor that triggers a cascade of events that results in the inappropriate fibrosis both in the dermis and in deeper tissues. Nephrogenic systemic fibrosis has been shown to cause these lesions in the lungs, pleura, diaphragm, myocardium, pericardium, and dura mater, the presence of which are typically indicative of severe progression of NSF. In cases where the lesions are manifest in the periarticular tissue, joint contractures and restricted range of motion can often result. We provide a quick synopsis of NSF, and a short case study that describes the authors\u2019 experience with one of their patients who requested a surgical consult as a result of being wheelchair-bound due to NSF\u2019s sequelae. (J Am Podiatr Med Assoc 102(5): 419-421, 2012)<\/jats:p>","DOI":"10.7547\/1020419","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T09:47:20Z","timestamp":1396345640000},"page":"419-421","source":"Crossref","is-referenced-by-count":3,"title":["Nephrogenic Systemic Fibrosis in the Podiatric Patient"],"prefix":"10.3390","volume":"102","author":[{"given":"Lewis","family":"Freed","sequence":"first","affiliation":[{"name":"East Valley Foot and Ankle Specialists, Mesa, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Podiatry and Orthopedics, Jewish Hospital & St. Mary\u2019s Healthcare, University of Louisville Hospital, Louisville, KY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gooch","sequence":"additional","affiliation":[{"name":"East Valley Foot and Ankle Specialists, Mesa, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"b1-1020419","series-title":"Semin Arthritis Rheum","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.semarthrit.2005.08.002","article-title":"Description of 12 cases of nephrogenic fibrosing dermopathy and review of the literature.","volume":"35","author":"Mendoza, FA","year":"2006","unstructured":"Mendoza, FA, CMArtlett, NSandorfi, et al. :Description of 12 cases of nephrogenic fibrosing dermopathy and review of the literature. .Semin Arthritis Rheum35::238. ,2006. .10.1016\/j.semarthrit.2005.08.00216461069"},{"key":"b2-1020419","series-title":"Up-to-date online 17.3","article-title":"Nephrogenic systemic fibrosis\/nephrogenic fibrosing dermopathy in advanced renal failure.","author":"Miskulin, D","unstructured":"Miskulin, D, AGul, MRRudnick, et al. :Nephrogenic systemic fibrosis\/nephrogenic fibrosing dermopathy in advanced renal failure. .Up-to-date online 17.3 .Available at: http:\/\/uptodateonline.com\/online\/content\/topic.do?topicKey=dialysis\/48700&selectedTitle=1%7E77&source=search_result. .Accessed November 21, 2009."},{"key":"b3-1020419","series-title":"Curr Opin Rheumatol","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1097\/01.bor.0000245725.94887.8d","article-title":"Nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy).","volume":"18","author":"Galan, A","year":"2006","unstructured":"Galan, A, SECowper, and RBucala. :Nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy). .Curr Opin Rheumatol18::614. ,2006. .1705350710.1097\/01.bor.0000245725.94887.8d"},{"key":"b4-1020419","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1148\/radiol.2423061640","article-title":"Gadolinium-based MR contrast agents and nephrogenic systemic fibrosis.","volume":"242","author":"Kuo, PH","year":"2007","unstructured":"Kuo, PH, EKanal, AKAbu-Alfa, et al. :Gadolinium-based MR contrast agents and nephrogenic systemic fibrosis. .Radiology242::647. ,2007. .10.1148\/radiol.242306164017213364"},{"key":"b5-1020419","series-title":"Semin Arthritis Rheum","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.semarthrit.2005.09.005","article-title":"Nephrogenic fibrosing dermopathy\/nephrogenic systemic fibrosis-setting the record straight.","volume":"35","author":"Cowper, SE","year":"2006","unstructured":"Cowper, SE, RBucala, and PELeboit. :Nephrogenic fibrosing dermopathy\/nephrogenic systemic fibrosis-setting the record straight. .Semin Arthritis Rheum35::208. ,2006. .10.1016\/j.semarthrit.2005.09.00516461067"},{"key":"b6-1020419","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1056\/NEJMcpc049026","article-title":"Case records of the Massachusetts General Hospital. 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