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Terbinafine, 250 mg, therapy was significantly superior to all treatments except itraconazole, 400 mg, pulse therapy; itraconazole, 200 mg, therapy was significantly superior to fluconazole and the topical treatments; and fluconazole, efinaconazole, ciclopirox, terbinafine nail solution, and amorolfine treatments were significantly superior to only placebo. These results support the superiority of 12-week continuous terbinafine, 250 mg, therapy and itraconazole, 400 mg, pulse therapy (1 week per month for 3 months) while suggesting the equivalence of topical therapies. These results reflect findings from the literature and treatment efficacy observed in clinical practice.<\/jats:p>","DOI":"10.7547\/13-110.1","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T10:20:14Z","timestamp":1405592414000},"page":"357-366","source":"Crossref","is-referenced-by-count":20,"title":["Therapies for Onychomycosis"],"prefix":"10.3390","volume":"105","author":[{"given":"Aditya K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Mediprobe Research Inc, London, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanne","family":"Daigle","sequence":"additional","affiliation":[{"name":"Mediprobe Research Inc, London, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Paquet","sequence":"additional","affiliation":[{"name":"Mediprobe Research Inc, London, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"i8750-7315-105-4-357-b01","series-title":"Int J Dermatol","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1046\/j.1365-4362.1997.00163.x","article-title":"The effect of toenail onychomycosis on patient quality of life","volume":"36","author":"Elewski\n              BE","year":"1997","unstructured":"Elewski\n              BE\n            \n          : The effect of toenail onychomycosis on patient quality of life. 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