{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:28:51Z","timestamp":1787678931088,"version":"build-2784847793"},"reference-count":19,"publisher":"MDPI AG","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title\/>\n                  <jats:sec id=\"st1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We sought to evaluate the efficacy of efinaconazole topical solution, 10%, in patients with onychomycosis and coexisting tinea pedis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 1,655 patients, aged 18 to 70 years, randomized (3:1) to receive efinaconazole topical solution, 10%, or vehicle from two identical multicenter, double-blind, vehicle-controlled 48-week studies evaluating safety and efficacy. The primary end point was complete cure rate (0% clinical involvement of the target toenail and negative potassium hydroxide examination and fungal culture findings) at week 52. Three groups were compared: patients with onychomycosis and coexisting interdigital tinea pedis on-study (treated or left untreated) and those with no coexisting tinea pedis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Treatment with efinaconazole topical solution, 10%, was significantly more effective than vehicle use irrespective of the coexistence of tinea pedis or its treatment. Overall, 352 patients with onychomycosis (21.3%) had coexisting interdigital tinea pedis, with 215 of these patients (61.1%) receiving investigator-approved topical antifungal agents for their tinea pedis in addition to their randomized onychomycosis treatment. At week 52, efinaconazole complete cure rates of 29.4% were reported in patients with onychomycosis when coexisting tinea pedis was treated compared with 16.1% when coexisting tinea pedis was not treated. Both cure rates were significant compared with vehicle (\n                      <jats:italic>P<\/jats:italic>\n                      = .003 and .045, respectively), and in the latter subgroup, no patients treated with vehicle achieved a complete cure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment of coexisting tinea pedis in patients with onychomycosis enhances the efficacy of once-daily topical treatment with efinaconazole topical solution, 10%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7547\/14-088","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T20:12:31Z","timestamp":1443730351000},"page":"407-411","source":"Crossref","is-referenced-by-count":25,"title":["Efinaconazole Topical Solution, 10%"],"prefix":"10.3390","volume":"105","author":[{"given":"Bryan","family":"Markinson","sequence":"first","affiliation":[{"name":"Division of Podiatric Medicine and Surgery, Leni and Peter W. 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