{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:13:14Z","timestamp":1783509194455,"version":"3.55.0"},"reference-count":12,"publisher":"MDPI AG","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:p>First described in 1963, eccrine syringofibroadenoma (ESFA) is a rare benign tumor that proliferates with differentiation toward ductal eccrine structures. There are many clinical presentations, including plaques, papules, verrucous plaques, keratotic tumors, and solitary tumors. The age of onset varies, with presentation between 16 and 80 years; however, solitary lesions are seen most commonly in the seventh and eighth decades. Here, we present the case of a 72-year-old woman referred to our outpatient clinic with a nodule on her leg. The histopathology result was ESFA. The lesion regressed after six cryotherapy sessions. Physicians should consider the possibility of ESFA and must remember its malignant potential in elderly patients.<\/jats:p>","DOI":"10.7547\/15-108","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T15:28:19Z","timestamp":1465226899000},"page":"237-238","source":"Crossref","is-referenced-by-count":2,"title":["Solitary Eccrine Syringofibroadenoma and Successful Treatment with Cryotherapy"],"prefix":"10.3390","volume":"106","author":[{"given":"Dilek Biyik","family":"Ozkaya","sequence":"first","affiliation":[{"name":"Department of Dermatoveneorology, Bezmialem Vakif University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Su","sequence":"first","affiliation":[{"name":"Department of Dermatoveneorology, Bezmialem Vakif University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An\u0131l G\u00fclsel","family":"Bahal\u0131","sequence":"first","affiliation":[{"name":"Department of Dermatoveneorology, Bezmialem Vakif University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bugce","family":"Topuk\u00e7u","sequence":"first","affiliation":[{"name":"Department of Dermatoveneorology, Bezmialem Vakif University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didem","family":"Dizman","sequence":"first","affiliation":[{"name":"Department of Dermatoveneorology, Bezmialem Vakif University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Tosuner","sequence":"first","affiliation":[{"name":"Department of Pathology, Bezmialem Vakif University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuyan","family":"Demirkesen","sequence":"first","affiliation":[{"name":"Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahide","family":"Onsun","sequence":"first","affiliation":[{"name":"Department of Dermatoveneorology, Bezmialem Vakif University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"ref21","first-page":"58","article-title":"Eccrine syringofibroadenoma: an unusual presentation of a rare disease","volume":"21","author":"Ahcar","year":"2011","journal-title":"J Pak Assoc Derma"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0190-9622(97)70245-7","article-title":"Eccrine syringofibroadenoma: multiple lesions representing a new cutaneous marker of the Sch\u00f6pf syndrome, and solitary nonhereditary tumors","volume":"36","author":"Starink","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/0019-5154.147847","article-title":"Solitary eccrine syringofibroadenoma with nail involvement: a rare entity","volume":"60","author":"Arora","year":"2015","journal-title":"Indian J Dermatol"},{"key":"ref11","first-page":"112","article-title":"An unusual presentation and a new treatment of eccrine syringofibroadenoma","volume":"16","author":"Jowker","year":"2006","journal-title":"J Pak Assoc Derma"},{"key":"ref01","first-page":"143","article-title":"Considerations on fibro-epithelial tumors. Exocrine syringofibradenoma","volume":"90","author":"Mascaro","year":"1963","journal-title":"Ann Dermatol Syphiligr (Paris)"},{"key":"ref41","first-page":"650","article-title":"Reactive eccrine syringofibroadenoma: an association with chronic foot ulcer in a patient with diabetes mellitus","volume":"41","author":"Utani","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/0019-5154.147847","article-title":"Solitary eccrine syringofibroadenoma with nail involvement: a rare entity","volume":"60","author":"Arora","year":"2015","journal-title":"Indian J Dermatol"},{"key":"ref81","first-page":"58","article-title":"Eccrine syringofibroadenoma: an unusual presentation of a rare disease","volume":"21","author":"Ahcar","year":"2011","journal-title":"J Pak Assoc Derma"},{"key":"ref71","first-page":"112","article-title":"An unusual presentation and a new treatment of eccrine syringofibroadenoma","volume":"16","author":"Jowker","year":"2006","journal-title":"J Pak Assoc Derma"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0190-9622(97)70245-7","article-title":"Eccrine syringofibroadenoma: multiple lesions representing a new cutaneous marker of the Sch\u00f6pf syndrome, and solitary nonhereditary tumors","volume":"36","author":"Starink","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"ref101","first-page":"650","article-title":"Reactive eccrine syringofibroadenoma: an association with chronic foot ulcer in a patient with diabetes mellitus","volume":"41","author":"Utani","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"ref61","first-page":"143","article-title":"Considerations on fibro-epithelial tumors. 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