{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:02Z","timestamp":1783509242007,"version":"3.55.0"},"reference-count":26,"publisher":"MDPI AG","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:p>Primary bone lymphoma is a rare disease, accounting for less than 5% of all extranodal lymphoma. Although the femur is cited as being the most common site, primary bone lymphoma is rare, accounting for less than 1% of all non-Hodgkin's lymphoma. Herein we present a case of diffuse B-cell\u2013type malignant lymphoma manifested as a large soft-tissue mass of the leg, via metastasis of primary non-Hodgkin's lymphoma of the femur, which went untreated. We highlight the advantages of various imaging modalities used throughout the process of diagnosis and treatment because accurate and early diagnosis are essential. This case gives us a unique opportunity to witness the rapid progression of metastasis and an atypical location.<\/jats:p>","DOI":"10.7547\/15-115","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T10:55:17Z","timestamp":1521197717000},"page":"52-57","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Extranodal Metastasis of Primary Bone Lymphoma in the Lower Extremity"],"prefix":"10.3390","volume":"108","author":[{"given":"Elizabeth","family":"Hernandez","sequence":"first","affiliation":[{"name":"Apolo and Hernandez Foot and Ankle Surgery, Coral Gables, FL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Rowan","sequence":"additional","affiliation":[{"name":"Department of Podiatry, Certified Foot & Ankle Specialists, Palm City, FL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Randall","sequence":"additional","affiliation":[{"name":"Department of Orthopedics\u2013Foot and Ankle, Palmetto General Hospital, Hialeah, FL."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"ref231","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.5858\/133.11.1868","article-title":"Primary bone lymphoma","volume":"133","author":"Bhagavathi","year":"2009","journal-title":"Arch Pathol Lab Med"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/ajh.23730","article-title":"Bone marrow 18F-fluoro-2-deoxy-D-glucose positron emission tomography\/computed tomography cannot replace bone marrow biopsy in diffuse large B-cell lymphoma","volume":"89","author":"Adams","year":"2014","journal-title":"Am J Hematol"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1093\/annonc\/mdt533","article-title":"Systemic review and meta-analysis on the diagnostic performance of FDG-PET\/CT in detecting bone marrow involvement in newly diagnosed Hodgkin lymphoma: is bone 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