{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:10:05Z","timestamp":1791519005839,"version":"4.3.4"},"reference-count":34,"publisher":"MDPI AG","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We sought to evaluate the relationship between baseline hemoglobin A1c (HbA1c) level and clinical outcomes, including foot ulcer outcome (resolved versus unresolved) and wound-healing time, in individuals with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective observational study was conducted on 99 patients presenting with a diabetic foot ulceration. Patient and ulcer characteristics were recorded. Patients were followed up for a maximum of 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>After 1 year of follow-up, 77% of ulcers healed and 23% did not heal. Although this study demonstrated that the baseline HbA1c reading was not a significant predictor of foot ulcer outcome (P = .603, resolved versus amputated), on further statistical analyses, when HbA1c was compared with the time taken for complete ulcer healing in the resolved group (n = 77), it proved to be significant (P = .009).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These findings have important implications for clinical practice, especially in an outpatient setting. Improving glycemic control may improve ulcer outcomes. Prediction of outcome may be helpful for health-care professionals in individualizing and optimizing clinical assessment and management of patients. Identification of determinants of outcome could result in improved health outcomes, improved quality of life, and fewer diabetes-related foot complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7547\/15-176","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T15:51:07Z","timestamp":1504799467000},"page":"272-279","source":"Crossref","is-referenced-by-count":21,"title":["Does Baseline Hemoglobin A1c Level Predict Diabetic Foot Ulcer Outcome or Wound Healing Time?"],"prefix":"10.3390","volume":"107","author":[{"given":"Lourdes","family":"Vella","sequence":"first","affiliation":[{"name":"Department of Health, Msida, Malta."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Gatt","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Malta, Msida, Malta."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Formosa","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Malta, Msida, Malta."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"ref311","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1136\/bmj.332.7538.407","article-title":"Diabetic foot ulcers","volume":"332","author":"Edmonds","year":"2006","journal-title":"BMJ"},{"key":"ref231","first-page":"1655","article-title":"Diabetic foot ulcers: pathogenesis and management","volume":"66","author":"Frykberg","year":"2002","journal-title":"Am Fam Physician"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1016\/j.jacc.2011.08.023","article-title":"ACCF\/AHA Focused Update of the Guideline for the Management of Patients With Peripheral Artery Disease (updating the 2005 guideline): a report of the American College of Cardiology 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