{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:07Z","timestamp":1783509247540,"version":"3.55.0"},"reference-count":18,"publisher":"MDPI AG","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:p>Osteolysis, caused by active resorption of bone matrix by osteoclasts, can be primary or can develop secondary to a variety of disease processes. An elevated level of inflammatory cytokines in the local milieu and increased blood flow secondary to infection or autonomic neuropathy stimulate the osteoclasts and cause bone loss in the diabetic foot. Charcot's neuroarthropathy and osteomyelitis are well-known foot complications of diabetes, and secondary osteolysis has largely been underappreciated and, hence, underreported. Plain radiographs, an initial component in the evaluation of the diabetic foot, may not successfully differentiate secondary osteolysis from osteomyelitis. We describe a patient with phalangeal osteolysis secondary to soft-tissue infection in whom a correct and timely diagnosis helped avoid unnecessary surgical interventions.<\/jats:p>","DOI":"10.7547\/16-004","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T15:04:16Z","timestamp":1513609456000},"page":"538-540","source":"Crossref","is-referenced-by-count":2,"title":["Reversible Secondary Osteolysis in Diabetic Foot Infection"],"prefix":"10.3390","volume":"107","author":[{"given":"Partha P.","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Department of Medicine, Midnapore Medical College and Hospital, Midnapore, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajitesh","family":"Roy","sequence":"additional","affiliation":[{"name":"Ruby General Hospital, Kolkata, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satinath","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhankar","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"ref131","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2337\/dc06-1572","article-title":"Probe-to-bone test for diagnosing diabetic foot osteomyelitis: reliable or relic?","volume":"30","author":"Lavery","year":"2007","journal-title":"Diabetes Care"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S1067-2516(97)80076-2","article-title":"Osteolysis versus osteomyelitis: a clinical case report","volume":"36","author":"Gretz","year":"1997","journal-title":"J Foot Ankle Surg"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.2522\/ptj.20080025","article-title":"Inflammatory osteolysis in diabetic neuropathic (Charcot) arthropathies of the foot","volume":"88","author":"Sinacore","year":"2008","journal-title":"Phys Ther"},{"key":"ref51","article-title":"\u201cLocal Gigantism,\u201d","author":"Pendsey","year":"2003","journal-title":"Diabetic Foot: A Clinical Atlas, 1st Ed"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-323-04145-4.50019-3","article-title":"\u201cThe Charcot Foot (Pied de Charcot),\u201d","author":"Sanders","year":"2008","journal-title":"Levin and O'Neal's The Diabetic Foot, 7th Ed"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0033-8389(02)00036-2","article-title":"Work-up of the diabetic foot","volume":"40","author":"Morrison","year":"2002","journal-title":"Radiol Clin North Am"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S1067-2516(97)80076-2","article-title":"Osteolysis versus osteomyelitis: a clinical case report","volume":"36","author":"Gretz","year":"1997","journal-title":"J Foot Ankle Surg"},{"key":"ref01","article-title":"The case of the missing wrist: a probable case of idiopathic osteolysis","author":"Garingarao","year":"2017","journal-title":"BMJ Case Rep 2013"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1001\/jama.1962.03050500054015b","article-title":"Spontaneous osteolysis following acute osteomyelitis","volume":"182","author":"Weissman","year":"1962","journal-title":"JAMA"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/ar67","article-title":"Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications","volume":"2","author":"Goldring","year":"2000","journal-title":"Arthritis Res"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1001\/jama.1962.03050500054015b","article-title":"Spontaneous osteolysis following acute osteomyelitis","volume":"182","author":"Weissman","year":"1962","journal-title":"JAMA"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2337\/dc06-1572","article-title":"Probe-to-bone test for diagnosing diabetic foot osteomyelitis: reliable or relic?","volume":"30","author":"Lavery","year":"2007","journal-title":"Diabetes Care"},{"key":"ref141","article-title":"\u201cLocal Gigantism,\u201d","author":"Pendsey","year":"2003","journal-title":"Diabetic Foot: A Clinical Atlas, 1st Ed"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0033-8389(02)00036-2","article-title":"Work-up of the diabetic foot","volume":"40","author":"Morrison","year":"2002","journal-title":"Radiol Clin North Am"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/ar67","article-title":"Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications","volume":"2","author":"Goldring","year":"2000","journal-title":"Arthritis Res"},{"key":"ref111","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-323-04145-4.50019-3","article-title":"\u201cThe Charcot Foot (Pied de Charcot),\u201d","author":"Sanders","year":"2008","journal-title":"Levin and O'Neal's The Diabetic Foot, 7th Ed"},{"key":"ref91","article-title":"The case of the missing wrist: a probable case of idiopathic osteolysis","author":"Garingarao","year":"2017","journal-title":"BMJ Case Rep 2013"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.2522\/ptj.20080025","article-title":"Inflammatory osteolysis in diabetic neuropathic (Charcot) arthropathies of the foot","volume":"88","author":"Sinacore","year":"2008","journal-title":"Phys Ther"}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/japma\/article-pdf\/107\/6\/538\/1402992\/16-004.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/japma\/article-pdf\/107\/6\/538\/1402992\/16-004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:17:18Z","timestamp":1783505838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/107\/6\/538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,1]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11,1]]}},"URL":"https:\/\/doi.org\/10.7547\/16-004","relation":{},"ISSN":["8750-7315","1930-8264"],"issn-type":[{"value":"8750-7315","type":"print"},{"value":"1930-8264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,1]]}}}