{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:28:12Z","timestamp":1788607692450,"version":"build-2803163510"},"reference-count":64,"publisher":"MDPI AG","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>One relatively universal functional goal after major lower-limb amputation is ambulation in a prosthesis. This retrospective, observational investigation sought to 1) determine what percentage of patients successfully walked in a prosthesis within 1 year after major limb amputation and 2) assess which patient factors might be associated with ambulation at an urban US tertiary-care hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective medical record review was performed to identify consecutive patients undergoing major lower-limb amputation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The overall rate of ambulation in a prosthesis was 29.94% (50.0% of those with unilateral below-the-knee amputation [BKA] and 20.0% of those with unilateral above-the-knee amputation [AKA]). In 24.81% of patients with unilateral BKA or AKA, a secondary surgical procedure of the amputation site was required. In those with unilateral BKA or AKA, statistically significant factors associated with ambulation included male sex (odds ratio [OR] = 2.50) and at least 6 months of outpatient follow-up (OR = 8.10), survival for at least 1 postoperative year (OR = 8.98), ambulatory preamputation (OR = 14.40), returned home after the amputation (OR = 6.12), and healing of the amputation primarily without a secondary surgical procedure (OR = 3.62). Those who had a history of dementia (OR = 0.00), a history of peripheral arterial disease (OR = 0.35), and a preamputation history of ipsilateral limb revascularization (OR = 0.14) were less likely to walk. We also observed that patients with a history of outpatient evaluation by a podiatric physician before major amputation were 2.63 times as likely to undergo BKA as opposed to AKA and were 2.90 times as likely to walk after these procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results add to the body of knowledge regarding outcomes after major amputation and could be useful in the education and consent of patients faced with major amputation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7547\/16-073","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T13:19:23Z","timestamp":1509110363000},"page":"355-364","source":"Crossref","is-referenced-by-count":21,"title":["Rate of and Factors Associated with Ambulation After Unilateral Major Lower-Limb Amputation at an Urban US Tertiary-Care Hospital with a Multidisciplinary Limb Salvage Team"],"prefix":"10.3390","volume":"107","author":[{"given":"Laura E.","family":"Sansosti","sequence":"first","affiliation":[{"name":"Podiatric Surgical Residency Program, Temple University Hospital, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Crowell","sequence":"additional","affiliation":[{"name":"Podiatric Surgical Residency Program, Temple University Hospital, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric T.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Temple University Hospital, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Meyr","sequence":"additional","affiliation":[{"name":"Department of Podiatric Surgery, Temple University School of Podiatric Medicine, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"ref511","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0741-5214(03)00092-2","article-title":"Functional outcome in a contemporary series of major lower extremity amputations","volume":"38","author":"Nehler","year":"2003","journal-title":"J Vasc Surg"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3109\/09638288.2013.833311","article-title":"Expectations of rehabilitation following lower limb amputation: a qualitative study","volume":"36","author":"Ostler","year":"2014","journal-title":"Disabil Rehabil"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1002\/dmrr.833","article-title":"The diabetic foot: grand overview, epidemiology and pathogenesis","volume":"24","author":"Boulton","year":"2008","journal-title":"Diabetes Metab Res 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