{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:42Z","timestamp":1783509282727,"version":"3.55.0"},"reference-count":16,"publisher":"MDPI AG","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>Nail pathologies have a broad range of origin and may sometimes be complicated in presentation or clinical course, specifically when the pathology remains recalcitrant after treatment. In this case report we discuss a pathologic disorder that was initially misdiagnosed as a pyogenic granuloma surrounding an ingrown nail but was later found to be a benign neoplastic bone growth, Dupuytren exostosis, also known as a subungual exostosis. Operative treatment was deemed appropriate for the patient, and the exostosis was resected, leaving a soft-tissue void at the distal toe. The remaining void was filled with a perinatal graft, the use of which has been deemed effective anecdotally in both chronic and acute lower-extremity wounds but has not been widely discussed in the lower-extremity literature. This graft was placed to aid in wound healing over a potentially difficult wound bed. As amniotic, chorionic, and umbilical grafts become more prevalent in lower-extremity surgery, its antitumor effects should be further explored and published. This is the first case report, to our knowledge, of the successful use of a perinatal graft in the setting of a bone tumor, and it demonstrates that certain benign neoplasms can be treated with resection and placement of a perinatal graft while helping to prevent chronic wounds at surgical sites.<\/jats:p>","DOI":"10.7547\/17-207","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T17:42:46Z","timestamp":1601487766000},"source":"Crossref","is-referenced-by-count":0,"title":["A Novel Use of Umbilical Perinatal Graft in Subungual Exostosis Resection"],"prefix":"10.3390","volume":"110","author":[{"given":"Juan Carlos","family":"Goez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger 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      Benign subungual tumors.\n\t\t\t\t\tJ Hand Surg Am37: 1276,\n\t\t\t\t\t2012.\n\t\t\t\t10.1016\/j.jhsa.2012.04.00122560606"},{"key":"i8750-7315-110-4-Article_12-b02","series-title":"Radiographics","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1148\/rg.306105514","article-title":"Subungual tumors: clinicopathologic correlation with US and MR imaging findings","volume":"30","author":"Baek","year":"2010","unstructured":"Baek\n              HJ\n            \n            \n              Lee\n              SJ\n            \n            \n              Cho\n              KH\n            \n            :\n\t\t\t\t\t\n          Subungual tumors: clinicopathologic correlation with US and MR imaging findings.\n\t\t\t\t\tRadiographics30: 1621,\n\t\t\t\t\t2010.\n\t\t\t\thttp:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283104100012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1148\/rg.306105514"},{"key":"i8750-7315-110-4-Article_12-b03","series-title":"Clin Orthop Relat Res","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1007\/s11999-013-3345-4","article-title":"Subungual exostosis of the toes: a systematic review","volume":"472","author":"DaCambra","year":"2014","unstructured":"DaCambra\n              MP\n            \n            \n              Gupta\n              SKl\n            \n            \n              Ferri-de-Barros\n              F:\n            \n          \n          Subungual exostosis of the toes: a systematic review.\n\t\t\t\t\tClin Orthop Relat Res472: 1251,\n\t\t\t\t\t2014.\n\t\t\t\t10.1007\/s11999-013-3345-424146360"},{"key":"i8750-7315-110-4-Article_12-b04","series-title":"Cytotherapy","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jcyt.2013.07.005","article-title":"Human amniotic epithelial cells induce apoptosis of cancer cells: a new anti-tumor therapeutic strategy","volume":"16","author":"Nikenejad","year":"2014","unstructured":"Nikenejad\n              H\n            \n            \n              Khayat-Khoei\n              M\n            \n            \n              Peirovi\n              H\n            \n            :\n\t\t\t\t\t\n          Human amniotic epithelial cells induce apoptosis of cancer cells: a new anti-tumor therapeutic strategy.\n\t\t\t\t\tCytotherapy16: 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melanoma.\n\t\t\t\t\tKorean J Opthalmol26: 383,\n\t\t\t\t\t2012.\n\t\t\t\t10.3341\/kjo.2012.26.5.383"},{"key":"i8750-7315-110-4-Article_12-b06","series-title":"J Wound Care","doi-asserted-by":"publisher","first-page":"465","DOI":"10.12968\/jowc.2014.23.10.465","article-title":"Comparison of cryopreserved amniotic membrane and umbilical cord tissue with dehydrated amniotic membrane\/chorion tissue","volume":"23","author":"Cooke","year":"2014","unstructured":"Cooke\n              M\n            \n            \n              Tan\n              EK\n            \n            \n              Mandrycky\n              C\n            \n            :\n\t\t\t\t\t\n          Comparison of cryopreserved amniotic membrane and umbilical cord tissue with dehydrated amniotic membrane\/chorion tissue.\n\t\t\t\t\tJ Wound Care23: 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trial.\n\t\t\t\t\tPlast Reconstr Surg Glob Open4: e1095,\n\t\t\t\t\t2016.\n\t\t\t\t2782648710.1097\/GOX.0000000000001095"},{"key":"i8750-7315-110-4-Article_12-b10","series-title":"Biomaterials","doi-asserted-by":"publisher","first-page":"9917","DOI":"10.1016\/j.biomaterials.2013.09.002","article-title":"Umbilical cord and bone marrow mesenchymal stem cell seeding on macroporous calcium phosphate for bone regeneration in rat cranial defects","volume":"34","author":"Chen","year":"2013","unstructured":"Chen\n              W\n            \n            \n              Liu\n              J\n            \n            \n              Manuchehrabadi\n              N\n            \n            :\n\t\t\t\t\t\n          Umbilical cord and bone marrow mesenchymal stem cell seeding on macroporous calcium phosphate for bone regeneration in rat cranial defects.\n\t\t\t\t\tBiomaterials34: 9917,\n\t\t\t\t\t2013.\n\t\t\t\t2405449910.1016\/j.biomaterials.2013.09.002http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000328094600018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3"},{"key":"i8750-7315-110-4-Article_12-b11","series-title":"Adv Wound Care","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1089\/wound.2015.0634","article-title":"Use of placental membranes for the treatment of chronic diabetic foot ulcers","volume":"4","author":"Brantley","year":"2015","unstructured":"Brantley\n              J\n            \n            \n              Verla\n              T:\n            \n          \n          Use of placental membranes for the treatment of chronic diabetic foot ulcers.\n\t\t\t\t\tAdv Wound Care4: 545,\n\t\t\t\t\t2015.\n\t\t\t\thttp:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359481100004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1089\/wound.2015.0634"},{"key":"i8750-7315-110-4-Article_12-b12","series-title":"Pediatr Dermatol","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/j.1525-1470.1996.tb01205.x","article-title":"Subungual exostosis: case report and review of the literature","volume":"13","author":"Davis","year":"1996","unstructured":"Davis\n              DA\n            \n            \n              Cohen\n              PR:\n            \n          \n          Subungual exostosis: case report and review of the literature.\n\t\t\t\t\tPediatr Dermatol13: 212,\n\t\t\t\t\t1996.\n\t\t\t\t880612110.1111\/j.1525-1470.1996.tb01205.x"},{"key":"i8750-7315-110-4-Article_12-b13","series-title":"Dtsch Arztebl 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             CK\n            \n            \n              Patil\n              N\n            \n            :\n\t\t\t\t\t\n          Cell therapy for bone regeneration: bench to bedside.\n\t\t\t\t\tJ Biomed Mater Res B Appl Biomater89: 252,\n\t\t\t\t\t2009.\n\t\t\t\t18777578"}],"container-title":["Journal of the American Podiatric Medical 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