{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:31Z","timestamp":1783509271037,"version":"3.55.0"},"reference-count":83,"publisher":"MDPI AG","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec id=\"st1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D is an essential vitamin that targets several tissues and organs and plays an important role in calcium homeostasis. Vitamin D deficiency is common, particularly at higher latitudes, where there is reduced exposure to ultraviolet B radiation. We reviewed the role of vitamin D and its deficiency in foot and ankle pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The effects of vitamin D deficiency have been extensively studied, but only a small portion of the literature has focused on the foot and ankle. Most evidence regarding the foot and ankle consists of retrospective studies, which cannot determine whether vitamin D deficiency is, in fact, the cause of the pathologies being investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The available evidence suggests that insufficient vitamin D levels may result in an increased incidence of foot and ankle fractures. The effects of vitamin D deficiency on fracture healing, bone marrow edema syndrome, osteochondral lesions of the talus, strength around the foot and ankle, tendon disorders, elective foot and ankle surgery, and other foot and ankle conditions are less clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on the available evidence, we cannot recommend routine testing or supplementation of vitamin D in patients with foot and ankle pathology. However, supplementation is cheap, safe, and may be of benefit in patients at high risk for deficiency. When vitamin D is supplemented, the evidence suggests that calcium should be co-supplemented. Further high-quality research is needed into the effect of vitamin D in the foot and ankle. Cost-benefit analyses of routine testing and supplementation of vitamin D for foot and ankle pathology are also required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7547\/18-087","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T12:21:55Z","timestamp":1570450915000},"source":"Crossref","is-referenced-by-count":6,"title":["Vitamin D in the Foot and Ankle: A Review of the Literature"],"prefix":"10.3390","volume":"110","author":[{"given":"Karan","family":"Malhotra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Baggott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Livingstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"i8750-7315-110-3-Article_10-b01","series-title":"Am J Clin Nutr","doi-asserted-by":"publisher","first-page":"491S","DOI":"10.1093\/ajcn\/88.2.491S","article-title":"From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health","volume":"88","author":"Norman","year":"2008","unstructured":"Norman\n              AW:\n            \n          \n          From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health.\n\t\t\t\t\tAm J Clin Nutr88: 491S,\n\t\t\t\t\t2008.\n\t\t\t\t1868938910.1093\/ajcn\/88.2.491S"},{"key":"i8750-7315-110-3-Article_10-b02","series-title":"Nutrition","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.nut.2015.12.039","article-title":"Nutritional research may be useful in treating tendon injuries","volume":"32","author":"Curtis","year":"2016","unstructured":"Curtis\n              L:\n            \n          \n          Nutritional research may be useful in treating tendon injuries.\n\t\t\t\t\tNutrition32: 617,\n\t\t\t\t\t2016.\n\t\t\t\t2692106610.1016\/j.nut.2015.12.039"},{"key":"i8750-7315-110-3-Article_10-b03","series-title":"Modern Nutrition in Health and Disease,","first-page":"376","article-title":"\u201cVitamin D,\u201d","author":"Holick","year":"2006","unstructured":"Holick\n              MF:\n            \n          \n          \u201cVitamin D,\u201d\n          in\n          \n            Modern Nutrition in Health and Disease,\n          \n          edited by\n          \n            Shils,\n            ME\n          \n          \n            Shike,\n            M\n          \n          \n            Ross,\n            AC\n          \n          ,\n\t\t\t\t\tp376,\n\t\t\t\t\tLippincott Williams & Wilkins,\n\t\t\t\t\tPhiladelphia,\n\t\t\t\t\t2006."},{"key":"i8750-7315-110-3-Article_10-b04","series-title":"Exerc Sport Sci Rev","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1249\/JES.0000000000000013","article-title":"The emerging biomolecular role of vitamin D in skeletal muscle","volume":"42","author":"Pojednic","year":"2014","unstructured":"Pojednic\n              RM\n            \n            \n              Ceglia\n              L:\n            \n          \n          The emerging biomolecular role of vitamin D in skeletal muscle.\n\t\t\t\t\tExerc Sport Sci Rev42: 76,\n\t\t\t\t\t2014.\n\t\t\t\t2450873610.1249\/JES.0000000000000013"},{"key":"i8750-7315-110-3-Article_10-b05","series-title":"Cell Mol Biol (Noisy-le-grand)","first-page":"277","article-title":"The immunological functions of the vitamin D endocrine system","volume":"49","author":"Hayes","year":"2003","unstructured":"Hayes\n              CE\n            \n            \n              Nashold\n              FE\n            \n            \n              Spach\n              KM\n            \n            :\n\t\t\t\t\t\n          The immunological functions of the vitamin D endocrine system.\n\t\t\t\t\tCell Mol Biol (Noisy-le-grand)49: 277,\n\t\t\t\t\t2003."},{"key":"i8750-7315-110-3-Article_10-b06","series-title":"Diabet Med","first-page":"50","article-title":"Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES","volume":"29","author":"Soderstrom","year":"2012","unstructured":"Soderstrom\n              LH\n            \n            \n              Johnson\n              SP\n            \n            \n              Diaz\n              VA\n            \n            :\n\t\t\t\t\t\n          Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES.\n\t\t\t\t\tDiabet Med29: 50,\n\t\t\t\t\t2012."},{"key":"i8750-7315-110-3-Article_10-b07","series-title":"Br J Nutr","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1017\/S0007114514003018","article-title":"Vitamin D deficiency is associated with inflammatory cytokine concentrations in patients with diabetic foot infection","volume":"112","author":"Tiwari","year":"2014","unstructured":"Tiwari\n              S\n            \n            \n              Pratyush\n              DD\n            \n            \n              Gupta\n              SK\n            \n            :\n\t\t\t\t\t\n          Vitamin D deficiency is associated with inflammatory cytokine concentrations in patients with diabetic foot infection.\n\t\t\t\t\tBr J Nutr112: 1938,\n\t\t\t\t\t2014.\n\t\t\t\t2533171010.1017\/S0007114514003018"},{"key":"i8750-7315-110-3-Article_10-b08","series-title":"Am J Clin Nutr","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1093\/ajcn\/80.3.752","article-title":"Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y","volume":"80","author":"Bischoff-Ferrari","year":"2004","unstructured":"Bischoff-Ferrari\n              HA\n            \n            \n              Dietrich\n              T\n            \n            \n              Orav\n              EJ\n            \n            :\n\t\t\t\t\t\n          Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y.\n\t\t\t\t\tAm J Clin Nutr80: 752,\n\t\t\t\t\t2004.\n\t\t\t\t1532181810.1093\/ajcn\/80.3.752"},{"key":"i8750-7315-110-3-Article_10-b09","series-title":"Am J Pathol","first-page":"171","article-title":"Pitt MJ: 1 alpha, 25-Dihydroxyvitamin D3 a metabolite of vitamin D that promotes bone repair","volume":"106","author":"Brumbaugh","year":"1982","unstructured":"Brumbaugh\n              PF\n            \n            \n              Speer\n              DP\n            \n          \n          Pitt MJ: 1 alpha, 25-Dihydroxyvitamin D3 a metabolite of vitamin D that promotes bone repair.\n\t\t\t\t\tAm J Pathol106: 171,\n\t\t\t\t\t1982.\n\t\t\t\t6895976"},{"key":"i8750-7315-110-3-Article_10-b10","series-title":"Acta Neurol Scand","first-page":"37","article-title":"Myopathy and neuropathy associated with osteomalacia","volume":"51","author":"Skaria","year":"1975","unstructured":"Skaria\n              J\n            \n            \n              Katiyar\n              BC\n            \n            \n              Srivastava\n              TP\n            \n            :\n\t\t\t\t\t\n          Myopathy and neuropathy associated with osteomalacia.\n\t\t\t\t\tActa Neurol Scand51: 37,\n\t\t\t\t\t1975.\n\t\t\t\t1119316"},{"key":"i8750-7315-110-3-Article_10-b11","series-title":"Mol Aspects Med","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.mam.2008.07.002","article-title":"Vitamin D and skeletal muscle tissue and function","volume":"29","author":"Ceglia","year":"2008","unstructured":"Ceglia\n              L:\n            \n          \n          Vitamin D and skeletal muscle tissue and function.\n\t\t\t\t\tMol Aspects Med29: 407,\n\t\t\t\t\t2008.\n\t\t\t\t1872793610.1016\/j.mam.2008.07.002"},{"key":"i8750-7315-110-3-Article_10-b12","series-title":"BMJ","doi-asserted-by":"publisher","first-page":"b5664","DOI":"10.1136\/bmj.b5664","article-title":"Diagnosis and management of vitamin D deficiency","volume":"340","author":"Pearce","year":"2010","unstructured":"Pearce\n              SH\n            \n            \n              Cheetham\n              TD:\n            \n          \n          Diagnosis and management of vitamin D deficiency.\n\t\t\t\t\tBMJ340: b5664,\n\t\t\t\t\t2010.\n\t\t\t\t10.1136\/bmj.b566420064851"},{"key":"i8750-7315-110-3-Article_10-b13","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","unstructured":"Holick\n              MF:\n            \n          \n          Vitamin D deficiency.\n\t\t\t\t\tN Engl J Med357: 266,\n\t\t\t\t\t2007.\n\t\t\t\t1763446210.1056\/NEJMra070553"},{"key":"i8750-7315-110-3-Article_10-b14","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1210\/jc.2015-2175","article-title":"Global Consensus Recommendations on Prevention and Management of Nutritional Rickets","volume":"101","author":"Munns","year":"2016","unstructured":"Munns\n              CF\n            \n            \n              Shaw\n              N\n            \n            \n              Kiely\n              M\n            \n            :\n\t\t\t\t\t\n          Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.\n\t\t\t\t\tJ Clin Endocrinol Metab101: 394,\n\t\t\t\t\t2016.\n\t\t\t\t10.1210\/jc.2015-217526745253"},{"key":"i8750-7315-110-3-Article_10-b15","series-title":"The National Academies Collection: Reports Funded by National Institutes of Health","article-title":"\u201cDietary Reference Intakes for Calcium and Vitamin D,\u201d","author":"Ross","year":"2011","unstructured":"Ross\n              AC\n            \n            \n              Taylor\n              CL\n            \n            \n              Yaktine\n              AL\n            \n            :\n\t\t\t\t\t\n          \u201cDietary Reference Intakes for Calcium and Vitamin D,\u201d\n          in\n          \n            The National Academies Collection: Reports Funded by National Institutes of Health\n          \n          , \n          National Academies Press,\n\t\t\t\t\tWashington, DC,\n\t\t\t\t\t2011."},{"key":"i8750-7315-110-3-Article_10-b16","series-title":"National Institute for Health and Care Excellence Web site","article-title":"Vitamin D: supplement use in specific population groups","year":"2018","unstructured":"Vitamin D: supplement use in specific population groups.\n\t\t\t\t\tNational Institute for Health and Care Excellence Web site.\n\t\t\t\t\tAvailable at: https:\/\/www.nice.org.uk\/guidance\/ph56. Updated August 30, 2017. Accessed January 2,2018."},{"key":"i8750-7315-110-3-Article_10-b17","series-title":"West J Med","first-page":"435","article-title":"Reversible muscle weakness in patients with vitamin D deficiency","volume":"167","author":"Ziambaras","year":"1997","unstructured":"Ziambaras\n              K\n            \n            \n              Dagogo-Jack\n              S:\n            \n          \n          Reversible muscle weakness in patients with vitamin D deficiency.\n\t\t\t\t\tWest J Med167: 435,\n\t\t\t\t\t1997.\n\t\t\t\t9426489"},{"key":"i8750-7315-110-3-Article_10-b18","series-title":"J Orthop Trauma","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/BOT.0000000000000455","article-title":"What is the role of vitamin D supplementation in acute fracture patients? a systematic review and meta-analysis of the prevalence of hypovitaminosis D and supplementation efficacy","volume":"30","author":"Sprague","year":"2016","unstructured":"Sprague\n              S\n            \n            \n              Petrisor\n              B\n            \n            \n              Scott\n              T\n            \n            :\n\t\t\t\t\t\n          What is the role of vitamin D supplementation in acute fracture patients? a systematic review and meta-analysis of the prevalence of hypovitaminosis D and supplementation efficacy.\n\t\t\t\t\tJ Orthop Trauma30: 53,\n\t\t\t\t\t2016.\n\t\t\t\t2642940610.1097\/BOT.0000000000000455"},{"key":"i8750-7315-110-3-Article_10-b19","series-title":"Ann Rheum Dis","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1136\/ard.2009.116053","article-title":"Musculoskeletal pain is associated with very low levels of vitamin D in men: results from the European Male Ageing Study","volume":"69","author":"McBeth","year":"2010","unstructured":"McBeth\n              J\n            \n            \n              Pye\n              SR\n            \n            \n              O'Neill\n              TW\n            \n            :\n\t\t\t\t\t\n          Musculoskeletal pain is associated with very low levels of vitamin D in men: results from the European Male Ageing Study.\n\t\t\t\t\tAnn Rheum Dis69: 1448,\n\t\t\t\t\t2010.\n\t\t\t\t10.1136\/ard.2009.11605320498201"},{"key":"i8750-7315-110-3-Article_10-b20","series-title":"Bone Miner","first-page":"205","article-title":"Vitamin D metabolites in patients with established non-union of fracture","volume":"1","author":"Haining","year":"1986","unstructured":"Haining\n              SA\n            \n            \n              Atkins\n              RM\n            \n            \n              Guilland-Cumming\n              DF\n            \n            :\n\t\t\t\t\t\n          Vitamin D metabolites in patients with established non-union of fracture.\n\t\t\t\t\tBone Miner1: 205,\n\t\t\t\t\t1986.\n\t\t\t\t3509893"},{"key":"i8750-7315-110-3-Article_10-b21","series-title":"Pol Orthop Traumatol","first-page":"1","article-title":"Vitamin D concentration in patients with normal and impaired bone union","volume":"78","author":"Boszczyk","year":"2013","unstructured":"Boszczyk\n              AM\n            \n            \n              Zakrzewski\n              P\n            \n            \n              Pomianowski\n              S:\n            \n          \n          Vitamin D concentration in patients with normal and impaired bone union.\n\t\t\t\t\tPol Orthop Traumatol78: 1,\n\t\t\t\t\t2013.\n\t\t\t\t23306314"},{"key":"i8750-7315-110-3-Article_10-b22","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1056\/NEJMoa1109617","article-title":"A pooled analysis of vitamin D dose requirements for fracture prevention","volume":"367","author":"Bischoff-Ferrari","year":"2012","unstructured":"Bischoff-Ferrari\n              HA\n            \n            \n              Willett\n              WC\n            \n            \n              Orav\n              EJ\n            \n            :\n\t\t\t\t\t\n          A pooled analysis of vitamin D dose requirements for fracture prevention.\n\t\t\t\t\tN Engl J Med367: 40,\n\t\t\t\t\t2012.\n\t\t\t\t10.1056\/NEJMoa110961722762317"},{"key":"i8750-7315-110-3-Article_10-b23","series-title":"Br J Gen Pract","first-page":"374","article-title":"Aches and pains in primary care","volume":"60","author":"Danczak","year":"2010","unstructured":"Danczak\n              A:\n            \n          \n          Aches and pains in primary care.\n\t\t\t\t\tBr J Gen Pract60: 374,\n\t\t\t\t\t2010.\n\t\t\t\t20423595"},{"key":"i8750-7315-110-3-Article_10-b24","series-title":"J Am Acad Orthop Surg","doi-asserted-by":"publisher","first-page":"123","DOI":"10.5435\/JAAOS-20-03-123","article-title":"Vitamin D in orthopaedics","volume":"20","author":"Patton","year":"2012","unstructured":"Patton\n              CM\n            \n            \n              Powell\n              AP\n            \n            \n              Patel\n              AA:\n            \n          \n          Vitamin D in orthopaedics.\n\t\t\t\t\tJ Am Acad Orthop Surg20: 123,\n\t\t\t\t\t2012.\n\t\t\t\t10.5435\/JAAOS-20-03-12322382284"},{"key":"i8750-7315-110-3-Article_10-b25","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1210\/jc.2004-0746","article-title":"Vitamin D deficiency and seasonal variation in an adult South Florida population","volume":"90","author":"Levis","year":"2005","unstructured":"Levis\n              S\n            \n            \n              Gomez\n              A\n            \n            \n              Jimenez\n              C\n            \n            :\n\t\t\t\t\t\n          Vitamin D deficiency and seasonal variation in an adult South Florida population.\n\t\t\t\t\tJ Clin Endocrinol Metab90: 1557,\n\t\t\t\t\t2005.\n\t\t\t\t10.1210\/jc.2004-0746"},{"key":"i8750-7315-110-3-Article_10-b26","article-title":"SACN vitamin D and health report","year":"2016","unstructured":"Scientific Advisory Committee on Nutrition:\n\t\t\t\t\tSACN vitamin D and health report.\n\t\t\t\t\tAvailable at: https:\/\/www.gov.uk\/government\/publications\/sacn-vitamin-d-and-health-report Published July 21,2016.\n\t\t\t\t\tAccessed May 2,2018.\n\t\t\t\t28025694"},{"key":"i8750-7315-110-3-Article_10-b27","series-title":"Curr Drug Targets","doi-asserted-by":"publisher","first-page":"4","DOI":"10.2174\/138945011793591635","article-title":"Vitamin D: evolutionary, physiological and health perspectives","volume":"12","author":"Holick","year":"2011","unstructured":"Holick\n              MF:\n            \n          \n          Vitamin D: evolutionary, physiological and health perspectives.\n\t\t\t\t\tCurr Drug Targets12: 4,\n\t\t\t\t\t2011.\n\t\t\t\t2079594110.2174\/138945011793591635"},{"key":"i8750-7315-110-3-Article_10-b28","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1210\/jc.2009-1773","article-title":"Update in vitamin D","volume":"95","author":"Adams","year":"2010","unstructured":"Adams\n              JS\n            \n            \n              Hewison\n              M:\n            \n          \n          Update in vitamin D.\n\t\t\t\t\tJ Clin Endocrinol Metab95: 471,\n\t\t\t\t\t2010.\n\t\t\t\t2013346610.1210\/jc.2009-1773"},{"key":"i8750-7315-110-3-Article_10-b29","series-title":"J Orthop Traumatol","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10195-014-0322-y","article-title":"Vitamin D status in patients with knee or hip osteoarthritis in a Mediterranean country","volume":"16","author":"Goula","year":"2015","unstructured":"Goula\n              T\n            \n            \n              Kouskoukis\n              A\n            \n            \n              Drosos\n              G\n            \n            :\n\t\t\t\t\t\n          Vitamin D status in patients with knee or hip osteoarthritis in a Mediterranean country.\n\t\t\t\t\tJ Orthop Traumatol16: 35,\n\t\t\t\t\t2015.\n\t\t\t\t2573660610.1007\/s10195-014-0322-y"},{"key":"i8750-7315-110-3-Article_10-b30","series-title":"J Bone Joint Surg Am","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.2106\/JBJS.I.01231","article-title":"Hypovitaminosis D in patients scheduled to undergo orthopaedic surgery: a single-center analysis","volume":"92","author":"Bogunovic","year":"2010","unstructured":"Bogunovic\n              L\n            \n            \n              Kim\n              AD\n            \n            \n              Beamer\n              BS\n            \n            :\n\t\t\t\t\t\n          Hypovitaminosis D in patients scheduled to undergo orthopaedic surgery: a single-center analysis.\n\t\t\t\t\tJ Bone Joint Surg Am92: 2300,\n\t\t\t\t\t2010.\n\t\t\t\t2092672410.2106\/JBJS.I.01231"},{"key":"i8750-7315-110-3-Article_10-b31","series-title":"Foot Ankle Int","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1177\/1071100715609054","article-title":"Vitamin D status in an elective orthopedic surgical population","volume":"37","author":"Michelson","year":"2016","unstructured":"Michelson\n              JD\n            \n            \n              Charlson\n              MD:\n            \n          \n          Vitamin D status in an elective orthopedic surgical population.\n\t\t\t\t\tFoot Ankle Int37: 186,\n\t\t\t\t\t2016.\n\t\t\t\t10.1177\/1071100715609054"},{"key":"i8750-7315-110-3-Article_10-b32","series-title":"Foot Ankle Surg","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.fas.2017.12.007","article-title":"Vitamin D levels in 577 consecutive elective foot & ankle surgery patients","volume":"25","author":"Aujla","year":"2019","unstructured":"Aujla\n              RS\n            \n            \n              Allen\n              PE\n            \n            \n              Ribbans\n              WJ:\n            \n          \n          Vitamin D levels in 577 consecutive elective foot & ankle surgery patients.\n\t\t\t\t\tFoot Ankle Surg25: 310,\n\t\t\t\t\t2019.\n\t\t\t\t2940917510.1016\/j.fas.2017.12.007"},{"key":"i8750-7315-110-3-Article_10-b33","series-title":"Infect Immun","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1128\/IAI.00353-08","article-title":"Vitamin D signaling, infectious diseases, and regulation of innate immunity","volume":"76","author":"White","year":"2008","unstructured":"White\n              JH:\n            \n          \n          Vitamin D signaling, infectious diseases, and regulation of innate immunity.\n\t\t\t\t\tInfect Immun76: 3837,\n\t\t\t\t\t2008.\n\t\t\t\t1850580810.1128\/IAI.00353-08"},{"key":"i8750-7315-110-3-Article_10-b34","series-title":"Br J Nutr","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1017\/S0007114516001094","article-title":"Raised serum 25-hydroxyvitamin D levels in patients with active diabetic foot ulcers","volume":"115","author":"Afarideh","year":"2016","unstructured":"Afarideh\n              M\n            \n            \n              Ghanbari\n              P\n            \n            \n              Noshad\n              S\n            \n            :\n\t\t\t\t\t\n          Raised serum 25-hydroxyvitamin D levels in patients with active diabetic foot ulcers.\n\t\t\t\t\tBr J Nutr115: 1938,\n\t\t\t\t\t2016.\n\t\t\t\t2715320310.1017\/S0007114516001094"},{"key":"i8750-7315-110-3-Article_10-b35","series-title":"BMJ","first-page":"i6583","article-title":"Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data","volume":"356","author":"Martineau","year":"2017","unstructured":"Martineau\n              AR\n            \n            \n              Jolliffe\n              DA\n            \n            \n              Hooper\n              RL\n            \n            :\n\t\t\t\t\t\n          Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of 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1154,\n\t\t\t\t\t2015."},{"key":"i8750-7315-110-3-Article_10-b66","series-title":"J Foot Ankle Surg","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1053\/j.jfas.2017.01.011","article-title":"Risk factors associated with nonunion after elective foot and ankle reconstruction: a case-control study","volume":"56","author":"Moore","year":"2017","unstructured":"Moore\n              KR\n            \n            \n              Howell\n              MA\n            \n            \n              Saltrick\n              KR\n            \n            :\n\t\t\t\t\t\n          Risk factors associated with nonunion after elective foot and ankle reconstruction: a case-control study.\n\t\t\t\t\tJ Foot Ankle Surg56: 457,\n\t\t\t\t\t2017.\n\t\t\t\t10.1053\/j.jfas.2017.01.01128476384"},{"key":"i8750-7315-110-3-Article_10-b67","series-title":"Arch Orthop Trauma Surg","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s00402-015-2376-6","article-title":"Perioperative vitamin D levels correlate with clinical outcomes after ankle fracture fixation","volume":"136","author":"Warner","year":"2016","unstructured":"Warner\n              SJ\n            \n            \n              Garner\n              MR\n            \n            \n              Nguyen\n              JT\n            \n            :\n\t\t\t\t\t\n          Perioperative vitamin D levels correlate with clinical outcomes after ankle fracture fixation.\n\t\t\t\t\tArch Orthop Trauma Surg136: 339,\n\t\t\t\t\t2016.\n\t\t\t\t10.1007\/s00402-015-2376-626660079"},{"key":"i8750-7315-110-3-Article_10-b68","series-title":"J Bone Miner Metab","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1007\/s00774-015-0694-y","article-title":"Association between vitamin D status and serum parathyroid hormone concentration and calcaneal stiffness in Japanese adolescents: sex differences in susceptibility to vitamin D deficiency","volume":"34","author":"Tsugawa","year":"2016","unstructured":"Tsugawa\n              N\n            \n            \n              Uenishi\n              K\n            \n            \n              Ishida\n              H\n            \n            :\n\t\t\t\t\t\n          Association between vitamin D status and serum parathyroid hormone concentration and calcaneal stiffness in Japanese adolescents: sex differences in susceptibility to vitamin D deficiency.\n\t\t\t\t\tJ Bone Miner Metab34: 464,\n\t\t\t\t\t2016.\n\t\t\t\t10.1007\/s00774-015-0694-y26260151"},{"key":"i8750-7315-110-3-Article_10-b69","series-title":"Scand J Public Health","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1080\/14034940410026273","article-title":"Is calcaneal stiffness more sensitive to physical activity than forearm bone mineral density? a population-based study of persons aged 20-79 years","volume":"32","author":"Grahn Kronhed","year":"2004","unstructured":"Grahn Kronhed\n              AC\n            \n            \n              Knutsson\n              I\n            \n            \n              Lofman\n              O\n            \n            :\n\t\t\t\t\t\n          Is calcaneal stiffness more sensitive to physical activity than forearm bone mineral density? a population-based study of persons aged 20-79 years.\n\t\t\t\t\tScand J Public Health32: 333,\n\t\t\t\t\t2004.\n\t\t\t\t1551366510.1080\/14034940410026273"},{"key":"i8750-7315-110-3-Article_10-b70","series-title":"Foot Ankle Int","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1177\/1071100717697427","article-title":"High prevalence of vitamin D deficiency in patients with bone marrow edema syndrome of the foot and ankle","volume":"38","author":"Horas","year":"2017","unstructured":"Horas\n              K\n            \n            \n              Fraissler\n              L\n            \n            \n              Maier\n              G\n            \n            :\n\t\t\t\t\t\n          High prevalence of vitamin D deficiency in patients with bone marrow edema syndrome of the foot and ankle.\n\t\t\t\t\tFoot Ankle Int38: 760,\n\t\t\t\t\t2017.\n\t\t\t\t10.1177\/107110071769742728340550"},{"key":"i8750-7315-110-3-Article_10-b71","series-title":"Foot Ankle Int","doi-asserted-by":"publisher","first-page":"S508","DOI":"10.3113\/FAI.2011.0508","article-title":"Transient bone marrow edema of the foot and ankle and its association with reduced systemic bone mineral density","volume":"32","author":"Sprinchorn","year":"2011","unstructured":"Sprinchorn\n              AE\n            \n            \n              O'Sullivan\n              R\n            \n            \n              Beischer\n              AD:\n            \n          \n          Transient bone marrow edema of the foot and ankle and its association with reduced systemic bone mineral density.\n\t\t\t\t\tFoot Ankle Int32: S508,\n\t\t\t\t\t2011.\n\t\t\t\t10.3113\/FAI.2011.0508"},{"key":"i8750-7315-110-3-Article_10-b72","series-title":"National Institutes of Health: Office of Dietary Supplements Web site","article-title":"Fact sheet for health professionals","year":"2018","unstructured":"Vitamin D:\n\t\t\t\t\tFact sheet for health professionals.\n\t\t\t\t\tNational Institutes of Health: Office of Dietary Supplements Web site.\n\t\t\t\t\tAvailable at: https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/. Accessed May 13,2018."},{"key":"i8750-7315-110-3-Article_10-b73","series-title":"NHS Choices Web site","article-title":"Vitamins, supplements and nutrition in pregnancy","year":"2018","unstructured":"Vitamins, supplements and nutrition in pregnancy.\n\t\t\t\t\tNHS Choices Web site.\n\t\t\t\t\tAvailable at: https:\/\/www.nhs.uk\/conditions\/pregnancy-and-baby\/vitamins-minerals-supplements-pregnant\/. Accessed April 10,2018."},{"key":"i8750-7315-110-3-Article_10-b74","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1001\/jama.2010.594","article-title":"Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial","volume":"303","author":"Sanders","year":"2010","unstructured":"Sanders\n              KM\n            \n            \n              Stuart\n              AL\n            \n            \n              Williamson\n              EJ\n            \n            :\n\t\t\t\t\t\n          Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial.\n\t\t\t\t\tJAMA303: 1815,\n\t\t\t\t\t2010.\n\t\t\t\t10.1001\/jama.2010.59420460620"},{"key":"i8750-7315-110-3-Article_10-b75","series-title":"Am J Clin Nutr","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1093\/ajcn\/69.5.842","article-title":"Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety","volume":"69","author":"Vieth","year":"1999","unstructured":"Vieth\n              R:\n            \n          \n          Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety.\n\t\t\t\t\tAm J Clin Nutr69: 842,\n\t\t\t\t\t1999.\n\t\t\t\t10.1093\/ajcn\/69.5.84210232622"},{"key":"i8750-7315-110-3-Article_10-b76","series-title":"Arch Osteoporos","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s11657-017-0324-5","article-title":"UK clinical guideline for the prevention and treatment of osteoporosis","volume":"12","author":"Compston","year":"2017","unstructured":"Compston\n              J\n            \n            \n              Cooper\n              A\n            \n            \n              Cooper\n              C\n            \n            :\n\t\t\t\t\t\n          UK clinical guideline for the prevention and treatment of osteoporosis.\n\t\t\t\t\tArch Osteoporos12: 43,\n\t\t\t\t\t2017.\n\t\t\t\t2842508510.1007\/s11657-017-0324-5"},{"key":"i8750-7315-110-3-Article_10-b77","series-title":"Ther Clin Risk Manag","doi-asserted-by":"publisher","first-page":"827","DOI":"10.2147\/TCRM.S3552","article-title":"The use of calcium and vitamin D in the management of osteoporosis","volume":"4","author":"Sunyecz","year":"2008","unstructured":"Sunyecz\n              JA:\n            \n          \n          The use of calcium and vitamin D in the management of osteoporosis.\n\t\t\t\t\tTher Clin Risk Manag4: 827,\n\t\t\t\t\t2008.\n\t\t\t\t10.2147\/TCRM.S355219209265"},{"key":"i8750-7315-110-3-Article_10-b78","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1210\/jcem-67-2-373","article-title":"Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin","volume":"67","author":"Webb","year":"1988","unstructured":"Webb\n              AR\n            \n            \n              Kline\n              L\n            \n            \n              Holick\n              MF:\n            \n          \n          Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin.\n\t\t\t\t\tJ Clin Endocrinol Metab67: 373,\n\t\t\t\t\t1988.\n\t\t\t\t10.1210\/jcem-67-2-373"},{"key":"i8750-7315-110-3-Article_10-b79","series-title":"Foot Ankle Int","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3113\/FAI.2012.0526","article-title":"Current concept review: vitamin D and stress fractures","volume":"33","author":"McCabe","year":"2012","unstructured":"McCabe\n              MP\n            \n            \n              Smyth\n              MP\n            \n            \n              Richardson\n              DR:\n            \n          \n          Current concept review: vitamin D and stress fractures.\n\t\t\t\t\tFoot Ankle Int33: 526,\n\t\t\t\t\t2012.\n\t\t\t\t10.3113\/FAI.2012.052622735329"},{"key":"i8750-7315-110-3-Article_10-b80","series-title":"National Institute for Health and Care Excellence Web site","article-title":"Costing statement: vitamin D: increasing supplement use among at-risk groups","year":"2014","unstructured":"Costing statement: vitamin D: increasing supplement use among at-risk groups.\n\t\t\t\t\tNational Institute for Health and Care Excellence Web site.\n\t\t\t\t\tAvailable at: https:\/\/www.nice.org.uk\/guidance\/ph56\/resources\/costing-statement-69288013. Published November2014.\n\t\t\t\t\tAccessed May 13,2018."},{"key":"i8750-7315-110-3-Article_10-b81","series-title":"BlueCross BlueShield Web site","year":"2018","unstructured":"Most people don't need vitamin D testing.\n\t\t\t\t\tBlueCross BlueShield Web site.\n\t\t\t\t\tAvailable at: https:\/\/www.bcbs.com\/news\/press-releases\/most-people-dont-need-vitamin-d-testing. Accessed May 13,2018."},{"key":"i8750-7315-110-3-Article_10-b82","series-title":"J Foot Ankle Surg","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1053\/j.jfas.2016.10.016","article-title":"American College of Foot and Ankle Surgeons((R)) Clinical Consensus Statement: perioperative management","volume":"56","author":"Meyr","year":"2017","unstructured":"Meyr\n              AJ\n            \n            \n              Mirmiran\n              R\n            \n            \n              Naldo\n              J\n            \n            :\n\t\t\t\t\t\n          American College of Foot and Ankle Surgeons((R)) Clinical Consensus Statement: perioperative management.\n\t\t\t\t\tJ Foot Ankle Surg56: 336,\n\t\t\t\t\t2017.\n\t\t\t\t10.1053\/j.jfas.2016.10.01628231966"},{"key":"i8750-7315-110-3-Article_10-b83","series-title":"Ortho Solutions Web site","article-title":"Consensus of the 7th round table: aspects of foot and ankle surgery","author":"Malhotra","year":"2018","unstructured":"Malhotra\n              K\n            \n            \n              Wright\n              S\n            \n            \n              Luckshmana\n              J\n            \n            :\n\t\t\t\t\t\n          Consensus of the 7th round table: aspects of foot and ankle surgery.\n\t\t\t\t\tOrtho Solutions Web site.\n\t\t\t\t\tAvailable at: http:\/\/orthosol.com\/wp-content\/uploads\/2018\/02\/7th-Consensus-of-Round-Table-2017-CARDIFF.pdf. Accessed February 15,2018."}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/110\/3\/i8750-7315-110-3-article_10.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/japma\/article-pdf\/doi\/10.7547\/18-087\/2558756\/i8750-7315-110-3-article_10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/110\/3\/i8750-7315-110-3-article_10.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/110\/3\/i8750-7315-110-3-article_10.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:17:54Z","timestamp":1783505874000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/110\/3\/18087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":83,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.7547\/18-087","relation":{},"ISSN":["8750-7315"],"issn-type":[{"value":"8750-7315","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]}}}