{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:42Z","timestamp":1783509282698,"version":"3.55.0"},"reference-count":10,"publisher":"MDPI AG","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>\n                    This case study presents a 72-year-old male patient who presented with multiple schwannomas. The patient underwent several soft-tissue mass excisions performed by general surgery and podiatry. The physical examination displayed multiple nodules on the left foot, ankle, and previously in the groin. Magnetic resonance imaging displayed high\u2013T2-weighted signal masses in the left plantar heel and ankle. These masses were excised and, through pathologic analysis, were diagnosed as schwannomas. Immunohistochemistry displayed a mosaic pattern of\n                    <jats:italic>INI1<\/jats:italic>\n                    expression, a gene associated with tumor suppression. The patient demonstrated findings consistent with multiple schwannomas (eg, schwannomatosis or neurofibromatosis type 2). Because of the patient's medical history, neurofibromatosis type 2 was more probable.\n                  <\/jats:p>","DOI":"10.7547\/18-192","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T18:10:07Z","timestamp":1605118207000},"source":"Crossref","is-referenced-by-count":1,"title":["Multiple Schwannomas of the Lower Extremity"],"prefix":"10.3390","volume":"110","author":[{"given":"Joseph T.","family":"Watson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rusheena","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"i8750-7315-110-5-Article_13-b01","series-title":"Oncologist","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1634\/theoncologist.2012-0162","article-title":"Clinical features of schwannomatosis: a retrospective analysis of 87 patients","volume":"17","author":"Merker","year":"2012","unstructured":"Merker\n              VL\n            \n            \n              Esparza\n              S\n            \n            \n              Smith\n              MJ\n            \n            :\n\t\t\t\t\t\n          Clinical features of schwannomatosis: a retrospective analysis of 87 patients.\n\t\t\t\t\tOncologist17: 1317,\n\t\t\t\t\t2012.\n\t\t\t\t10.1634\/theoncologist.2012-0162http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310500600014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f322927469"},{"key":"i8750-7315-110-5-Article_13-b02","series-title":"Otol Neurotol","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1097\/00129492-200501000-00016","article-title":"Incidence of vestibular schwannoma and neurofibromatosis 2 in the North West of England over a 10-year period: higher incidence than previously thought","volume":"26","author":"Evans","year":"2005","unstructured":"Evans\n              DG\n            \n            \n              Moran\n              A\n            \n            \n              King\n              A\n            \n            :\n\t\t\t\t\t\n          Incidence of vestibular schwannoma and neurofibromatosis 2 in the North West of England over a 10-year period: higher incidence than previously thought.\n\t\t\t\t\tOtol Neurotol26: 93,\n\t\t\t\t\t2005.\n\t\t\t\t10.1097\/00129492-200501000-00016"},{"key":"i8750-7315-110-5-Article_13-b03","series-title":"JAPMA","first-page":"302","article-title":"Subungual schwannoma with clinical, sonographic, and histologic correlation","volume":"104","author":"Soto","year":"2014","unstructured":"Soto\n              R\n            \n            \n              Aldunce\n              MJ\n            \n            \n              Wortsman\n              X\n            \n            :\n\t\t\t\t\t\n          Subungual schwannoma with clinical, sonographic, and histologic correlation.\n\t\t\t\t\tJAPMA104: 302,\n\t\t\t\t\t2014."},{"key":"i8750-7315-110-5-Article_13-b04","series-title":"JAPMA","first-page":"157","article-title":"Unusually large cellular schwannoma of the foot","volume":"95","author":"Pasternack","year":"2005","unstructured":"Pasternack\n              WA\n            \n            \n              Winter-Reiken\n              DJ:\n            \n          \n          Unusually large cellular schwannoma of the foot.\n\t\t\t\t\tJAPMA95: 157,\n\t\t\t\t\t2005."},{"key":"i8750-7315-110-5-Article_13-b05","series-title":"JAPMA","first-page":"51","article-title":"Multiple schwannomas of the foot. Case report and strategy for treatment","volume":"93","author":"Mott","year":"2003","unstructured":"Mott\n              RC\n            \n            \n              Dellon\n              AL:\n            \n          \n          Multiple schwannomas of the foot. Case report and strategy for treatment.\n\t\t\t\t\tJAPMA93: 51,\n\t\t\t\t\t2003."},{"key":"i8750-7315-110-5-Article_13-b06","series-title":"Orphanet J Rare Dis","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1750-1172-4-16","article-title":"Neurofibromatosis type 2 (NF2): a clinical and molecular review","volume":"4","author":"Evans","year":"2009","unstructured":"Evans\n              DG:\n            \n          \n          Neurofibromatosis type 2 (NF2): a clinical and molecular review.\n\t\t\t\t\tOrphanet J Rare Dis4: 16,\n\t\t\t\t\t2009.\n\t\t\t\t10.1186\/1750-1172-4-1619545378http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000267988800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3"},{"key":"i8750-7315-110-5-Article_13-b07","series-title":"Am J Hum Genet","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1086\/513207","article-title":"Germline mutation of INI1\/SMARCB1 in familial schwannomatosis","volume":"80","author":"Hulsebos","year":"2007","unstructured":"Hulsebos\n              TJ\n            \n            \n              Plomp\n              AS\n            \n            \n              Wolterman\n              RA\n            \n            :\n\t\t\t\t\t\n          Germline mutation of INI1\/SMARCB1 in familial schwannomatosis.\n\t\t\t\t\tAm J Hum Genet80: 805.\n\t\t\t\t\t2007.\n\t\t\t\t10.1086\/51320717357086http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245465200021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3"},{"key":"i8750-7315-110-5-Article_13-b08","series-title":"Genet Med","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1097\/GIM.0b013e3181ac9a27","article-title":"Neurofibromatosis 2 [bilateral acoustic neurofibromatosis, central neurofibromatosis, NF2, neurofibromatosis type II]","volume":"11","author":"Evans","year":"2009","unstructured":"Evans\n              DGR:\n            \n          \n          Neurofibromatosis 2 [bilateral acoustic neurofibromatosis, central neurofibromatosis, NF2, neurofibromatosis type II].\n\t\t\t\t\tGenet Med11: 599,\n\t\t\t\t\t2009.\n\t\t\t\t10.1097\/GIM.0b013e3181ac9a2719652604http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000270526200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3"},{"key":"i8750-7315-110-5-Article_13-b09","series-title":"Rev Neurol Dis","first-page":"E81","article-title":"The neurofibromatoses. Part 2. NF2 and schwannomatosis","volume":"6","author":"Lu-Emerson","year":"2009","unstructured":"Lu-Emerson\n              C\n            \n            \n              Plotkin\n              SR:\n            \n          \n          The neurofibromatoses. Part 2. NF2 and schwannomatosis.\n\t\t\t\t\tRev Neurol Dis6: E81,\n\t\t\t\t\t2009.\n\t\t\t\t19898272"},{"key":"i8750-7315-110-5-Article_13-b10","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1212\/01.WNL.0000163982.78900.AD","article-title":"Diagnostic criteria for schwannomatosis","volume":"64","author":"MacCollin","year":"2005","unstructured":"MacCollin\n              M\n            \n            \n              Chiocca\n              EA\n            \n            \n              Evans\n              DG\n            \n            :\n\t\t\t\t\t\n          Diagnostic criteria for schwannomatosis.\n\t\t\t\t\tNeurology64: 1838,\n\t\t\t\t\t2005.\n\t\t\t\t10.1212\/01.WNL.0000163982.78900.AD15955931"}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/110\/5\/i8750-7315-110-5-article_13.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/japma\/article-pdf\/doi\/10.7547\/18-192\/2644517\/i8750-7315-110-5-article_13.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/110\/5\/i8750-7315-110-5-article_13.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/110\/5\/i8750-7315-110-5-article_13.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:18:01Z","timestamp":1783505881000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/110\/5\/18192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":10,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.7547\/18-192","relation":{},"ISSN":["8750-7315"],"issn-type":[{"value":"8750-7315","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}