{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:28Z","timestamp":1783509268804,"version":"3.55.0"},"reference-count":6,"publisher":"MDPI AG","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>Cushing's syndrome is an uncommon clinical condition most frequently presenting with central obesity, facial rounding, proximal muscle weakness, and skin thinning. The objective of this case report is to highlight an unusual presentation of Cushing's syndrome. A 35-year-old woman presented to the orthopedic clinic with a 1-year history of foot pain without any history of trauma. Radiography of the foot showed multiple metatarsal fractures. Evaluation for secondary causes of reduced bone strength revealed that the patient had Cushing's disease, although other typical signs and symptoms were not remarkable. It can be concluded that Cushing's syndrome should always be included in the differential diagnosis of foot fracture without any evidence of trauma.<\/jats:p>","DOI":"10.7547\/19-024","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T17:01:05Z","timestamp":1624035665000},"source":"Crossref","is-referenced-by-count":3,"title":["Multiple Metatarsal Fractures: The First Manifestation of Cushing's Disease\u2014A Case Report"],"prefix":"10.3390","volume":"111","author":[{"given":"Vilim","family":"Molnar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Zekan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Du\u0161ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Ivkovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"i8750-7315-111-3-Article_2-b01","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/S0140-6736(14)61375-1","article-title":"Cushing's syndrome","volume":"386","author":"Lacroix","year":"2015","unstructured":"Lacroix\n              A\n            \n            \n              Feelders\n              RA\n            \n            \n              Stratakis\n              CA\n            \n            :\n          \n          Cushing's syndrome.\n\t\t\t\t\tLancet386: 913,\n\t\t\t\t\t2015.\n\t\t\t\t10.1016\/S0140-6736(14)61375-1http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360290000034&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f326004339"},{"key":"i8750-7315-111-3-Article_2-b02","series-title":"Pituitary","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s11102-005-1051-2","article-title":"Cushing's syndrome and bone","volume":"7","author":"Mancini","year":"2004","unstructured":"Mancini\n              T\n            \n            \n              Doga\n              M\n            \n            \n              Mazziotti\n              G\n            \n            :\n          \n          Cushing's syndrome and bone.\n\t\t\t\t\tPituitary7: 249,\n\t\t\t\t\t2004.\n\t\t\t\t1601045810.1007\/s11102-005-1051-2"},{"key":"i8750-7315-111-3-Article_2-b03","series-title":"J Bone Metab","doi-asserted-by":"publisher","first-page":"277","DOI":"10.11005\/jbm.2014.21.4.277","article-title":"Mutiple spontaneous rib fractures in patient with Cushing's syndrome","volume":"21","author":"Lee","year":"2014","unstructured":"Lee\n              HJ\n            \n            \n              Je\n              JH\n            \n            \n              Seo\n              JH\n            \n            :\n          \n          Mutiple spontaneous rib fractures in patient with Cushing's syndrome.\n\t\t\t\t\tJ Bone Metab21: 277,\n\t\t\t\t\t2014.\n\t\t\t\t10.11005\/jbm.2014.21.4.27725489577"},{"key":"i8750-7315-111-3-Article_2-b04","series-title":"J Orthop Case Rep","first-page":"77","article-title":"Bilateral adrenal adenoma presented as multiple metatarsal and phalangeal fractures","volume":"5","author":"LiYeung","year":"2015","unstructured":"LiYeung\n              LL\n            \n            \n              Lui\n              TH:\n            \n          \n          Bilateral adrenal adenoma presented as multiple metatarsal and phalangeal fractures.\n\t\t\t\t\tJ Orthop Case Rep5: 77,\n\t\t\t\t\t2015.\n\t\t\t\t27299107"},{"key":"i8750-7315-111-3-Article_2-b05","series-title":"Apley & Solomon's System of Orthopaedics and Trauma","first-page":"609","article-title":"\u201cThe Ankle and Foot,\u201d","author":"Blom","year":"2018","unstructured":"Blom\n              A\n            \n            \n              Warwick\n              D\n            \n            \n              Whitehouse\n              MR:\n            \n          \n          \u201cThe Ankle and Foot,\u201d\n          in\n          \n            Apley & Solomon's System of Orthopaedics and Trauma\n          ,\n\t\t\t\t\t609,\n\t\t\t\t\tCRC Press,\n\t\t\t\t\tBoca Raton, FL,\n\t\t\t\t\t2018."},{"key":"i8750-7315-111-3-Article_2-b06","series-title":"J Bone Metab","doi-asserted-by":"publisher","first-page":"153","DOI":"10.11005\/jbm.2012.19.2.153","article-title":"A case of Cushing syndrome diagnosed by recurrent pathologic fractures in a young woman","volume":"19","author":"Han","year":"2012","unstructured":"Han\n              JY\n            \n            \n              Lee\n              J\n            \n            \n              Kim\n              GE\n            \n            :\n          \n          A case of Cushing syndrome diagnosed by recurrent pathologic fractures in a young woman.\n\t\t\t\t\tJ Bone Metab19: 153,\n\t\t\t\t\t2012.\n\t\t\t\t10.11005\/jbm.2012.19.2.153"}],"container-title":["Journal of the American Podiatric Medical 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