{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:42Z","timestamp":1783509282675,"version":"3.55.0"},"reference-count":13,"publisher":"MDPI AG","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Giant cell tumor of the tendon sheath (GCTTS) in the foot is a rare pathology and is involved in the differential diagnosis of soft-tissue tumors of the foot and ankle. Although it can affect any age group, GCTTS mainly occurs at the 3rd and 5th decade and is more common in females. Histopathologic examination is a major definitive method for diagnosis, although physical examination and radiologic imaging are helpful in reaching a diagnosis preoperatively. Many treatment options exist but marginal excision is the most commonly used treatment. We describe the case of a 26-year-old pregnant woman with a multi-fragmented mass extending from the first web space to the plantar aspect of the metatarsophalangeal joint (MTP) of the left great toe associated with flexor hallucis longus tendon after trauma. She had pain that worsened with activity and wearing shoes. After pregnancy, a marginal excision with dorsal longitudinal incision in the first web space was performed under spinal anesthesia. The lesion was diagnosed as a localized type tenosynovial giant cell tumor. At the last follow-up appointment in the 23rd month, the patient was doing well and there was no recurrence of the lesion. GCSST should be considered in the differential diagnosis of plantar masses of foot. Although, GCTTS is frequently seen in females, it has not been previously reported in a pregnant woman with an extremely rare condition after trauma.<\/jats:p>","DOI":"10.7547\/19-038","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T10:53:28Z","timestamp":1567680808000},"source":"Crossref","is-referenced-by-count":0,"title":["A Pregnant Woman with Multi-Fragmented Giant Cell Tumor of Tendon Sheath: A Rare Anatomical Location"],"prefix":"10.3390","volume":"110","author":[{"given":"Mehmet","family":"Arican","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yal\u00e7\u0131n","family":"Turhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"i8750-7315-110-3-Article_18-b01","series-title":"J Bone Joint Surg Br","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1302\/0301-620X.84B7.0841000","article-title":"Giant-cell tumour of the tendon sheath in the foot and ankle","volume":"84","author":"Gibbons","year":"2002","unstructured":"Gibbons\n              CL\n            \n            \n              Khwaja\n              HA\n            \n            \n              Cole\n              AS\n            \n            :\n\t\t\t\t\t\n          Giant-cell tumour of the tendon sheath in the foot and ankle.\n\t\t\t\t\tJ Bone Joint Surg Br84: 1000,\n\t\t\t\t\t2002.\n\t\t\t\t10.1302\/0301-620X.84B7.084100012358361"},{"key":"i8750-7315-110-3-Article_18-b02","series-title":"J Foot Ankle Surg","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1053\/j.jfas.2012.09.008","article-title":"Giant cell tumor of the tendon sheath in the foot and ankle: case series and review of the literature","volume":"52","author":"Zhang","year":"2013","unstructured":"Zhang\n              Y\n            \n            \n              Huang\n              J\n            \n            \n              Ma\n              X\n            \n            :\n\t\t\t\t\t\n          Giant cell tumor of the tendon sheath in the foot and ankle: case series and review of the literature.\n\t\t\t\t\tJ Foot Ankle Surg52: 24,\n\t\t\t\t\t2013.\n\t\t\t\thttp:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000312889700006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f32308538310.1053\/j.jfas.2012.09.008"},{"key":"i8750-7315-110-3-Article_18-b03","series-title":"JAPMA","first-page":"249","article-title":"Giant Cell Tumor of the tendon sheath around the foot and ankle. 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A report of three cases and a literature review.\n\t\t\t\t\tJAPMA105: 249,\n\t\t\t\t\t2015."},{"key":"i8750-7315-110-3-Article_18-b04","series-title":"J Ultrasound Med","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.7863\/jum.2007.26.10.1333","article-title":"The value of sonography in diagnosing giant cell tumors of the tendon sheath","volume":"26","author":"Wang","year":"2007","unstructured":"Wang\n              Y\n            \n            \n              Tang\n              J\n            \n            \n              Luo\n              Y:\n            \n          \n          The value of sonography in diagnosing giant cell tumors of the tendon sheath.\n\t\t\t\t\tJ Ultrasound Med26: 1333,\n\t\t\t\t\t2007.\n\t\t\t\thttp:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000250244400006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f31790113610.7863\/jum.2007.26.10.1333"},{"key":"i8750-7315-110-3-Article_18-b05","series-title":"J Bone Joint Surg Br","first-page":"882","article-title":"The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis)","volume":"94","author":"van der Heijden","year":"2012","unstructured":"van der Heijden\n              L\n            \n            \n              Gibbons\n              CL\n            \n            \n              Dijkstra\n              PD\n            \n            :\n\t\t\t\t\t\n          The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis).\n\t\t\t\t\tJ Bone Joint Surg Br94:\n\t\t\t\t\t882,\n\t\t\t\t\t2012.\n\t\t\t\t22733940http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000306923600003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3"},{"issue":"(Suppl 2)","key":"i8750-7315-110-3-Article_18-b06","series-title":"J Clin Orthop Trauma","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jcot.2017.06.014","article-title":"Giant cell tumour of tendon sheath and synovial membrane: A review of 26 cases","volume":"8","author":"Kant","year":"2017","unstructured":"Kant\n              KS\n            \n            \n              Manav\n              AK\n            \n            \n              Kumar\n              R\n            \n            :\n\t\t\t\t\t\n          Giant cell tumour of tendon sheath and synovial membrane: A review of 26 cases.\n\t\t\t\t\tJ Clin Orthop Trauma8(Suppl 2): 96,\n\t\t\t\t\t2017.\n\t\t\t\t10.1016\/j.jcot.2017.06.014"},{"key":"i8750-7315-110-3-Article_18-b07","series-title":"J Clin Pathol","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1136\/jcp.54.5.404","article-title":"Giant cell tumour of tendon sheath (localised nodular tenosynovitis): clinicopathological features of 71 cases","volume":"54","author":"Monaghan","year":"2001","unstructured":"Monaghan\n              H\n            \n            \n              Salter\n              DM\n            \n            \n              Al-Nafussi\n              A:\n            \n          \n          Giant cell tumour of tendon sheath (localised nodular tenosynovitis): clinicopathological features of 71 cases.\n\t\t\t\t\tJ Clin Pathol54: 404,\n\t\t\t\t\t2001.\n\t\t\t\t1132884410.1136\/jcp.54.5.404"},{"key":"i8750-7315-110-3-Article_18-b08","series-title":"Int Orthop","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1007\/s00264-013-1994-2","article-title":"Nodular giant cell tumour of the tendon sheath of the hand: analysis of eighty-four cases: diagnostic decisions and outcome","volume":"37","author":"Lautenbach","year":"2013","unstructured":"Lautenbach\n              M\n            \n            \n              Kim\n              S\n            \n            \n              Millrose\n              M\n            \n            :\n\t\t\t\t\t\n          Nodular giant cell tumour of the tendon sheath of the hand: analysis of eighty-four cases: diagnostic decisions and outcome.\n\t\t\t\t\tInt Orthop37: 2211,\n\t\t\t\t\t2013.\n\t\t\t\t10.1007\/s00264-013-1994-223835561http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000326104400016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3"},{"key":"i8750-7315-110-3-Article_18-b09","series-title":"JAPMA","first-page":"333","article-title":"Rare giant cell tumor of the distal flexor digitorum longustendon sheath and early diagnosis with use of magnetic resonance \u0131maging","volume":"107","author":"Levi","year":"2017","unstructured":"Levi\n              M\n            \n            \n              Crafton\n              J:\n            \n          \n          Rare giant cell tumor of the distal flexor digitorum longustendon sheath and early diagnosis with use of magnetic resonance \u0131maging.\n\t\t\t\t\tJAPMA107: 333,\n\t\t\t\t\t2017."},{"key":"i8750-7315-110-3-Article_18-b10","series-title":"J Foot Ankle Surg","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1053\/j.jfas.2004.09.002","article-title":"Pigmented villonodular synovitis of the foot and ankle: a 12-year experience from a tertiary orthopedic Oncology Unit","volume":"43","author":"Bisbinas","year":"2004","unstructured":"Bisbinas\n              I\n            \n            \n              De Silva\n              U\n            \n            \n              Grimer\n              RJ:\n            \n          \n          Pigmented villonodular synovitis of the foot and ankle: a 12-year experience from a tertiary orthopedic Oncology Unit.\n\t\t\t\t\tJ Foot Ankle Surg43: 407,\n\t\t\t\t\t2004.\n\t\t\t\t1560505410.1053\/j.jfas.2004.09.002"},{"key":"i8750-7315-110-3-Article_18-b11","series-title":"J Hand Surg Br","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1054\/jhsb.2000.0522","article-title":"Giant cell tumours of tendon sheath: classification and recurrence rate","volume":"26","author":"Al-Qattan","year":"2001","unstructured":"Al-Qattan\n              MM:\n            \n          \n          Giant cell tumours of tendon sheath: classification and recurrence rate.\n\t\t\t\t\tJ Hand Surg Br26: 72,\n\t\t\t\t\t2001.\n\t\t\t\t1116202410.1054\/jhsb.2000.0522"},{"key":"i8750-7315-110-3-Article_18-b12","series-title":"J Hand Surg Am","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.jhsa.2009.12.004","article-title":"Recurrence of giant cell tumors in the hand: a prospective study","volume":"35","author":"Williams","year":"2010","unstructured":"Williams\n              J\n            \n            \n              Hodari\n              A\n            \n            \n              Janevski\n              P\n            \n            :\n\t\t\t\t\t\n          Recurrence of giant cell tumors in the hand: a prospective study.\n\t\t\t\t\tJ Hand Surg Am35: 451,\n\t\t\t\t\t2010.\n\t\t\t\t10.1016\/j.jhsa.2009.12.00420193861http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000277092800015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3"},{"key":"i8750-7315-110-3-Article_18-b13","series-title":"J Bone Joint Surg Br","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1302\/0301-620X.82B4.0820571","article-title":"Giant-cell tumour of the tendon sheath. Is radiotherapy indicated to prevent recurrence after surgery?","volume":"82","author":"Kotwal","year":"2000","unstructured":"Kotwal\n              PP\n            \n            \n              Gupta\n              V\n            \n            \n              Malhotra\n              R:\n            \n          \n          Giant-cell tumour of the tendon sheath. Is radiotherapy indicated to prevent recurrence after surgery?\n          J Bone Joint Surg Br\n          82\n          : \n          571,\n\t\t\t\t\t2000.\n\t\t\t\t10.1302\/0301-620X.82B4.082057110855885"}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/110\/3\/i8750-7315-110-3-article_18.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/japma\/article-pdf\/doi\/10.7547\/19-038\/2558835\/i8750-7315-110-3-article_18.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/110\/3\/i8750-7315-110-3-article_18.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/110\/3\/i8750-7315-110-3-article_18.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:17:56Z","timestamp":1783505876000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/110\/3\/19038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":13,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.7547\/19-038","relation":{},"ISSN":["8750-7315"],"issn-type":[{"value":"8750-7315","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]}}}