{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:23Z","timestamp":1783509263632,"version":"3.55.0"},"reference-count":19,"publisher":"MDPI AG","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>The giant cell tumor of tendon sheath (GCTTS) is a benign lesion most commonly attached to the tendons and bones of the fingers, hands, and wrists. The involvement of GCTTS to the foot is uncommon. The GCTTS invading tarsal bones and intertarsal joints is not described yet, and the appropriate diagnosis and treatment remain unclear. We report a case of GCTTS with the involvement of tarsal bones and intertarsal joint. Computed tomography scan and magnetic resonance imaging were used to further diagnose and evaluate the quality and range of tumor. The patient was treated with surgical excision of the tumor without application of bone graft. After adequate clearance of the tumor, the patient returned to an asymptomatic walk in 3 months. No malfunction, fracture, or tumor recurrence was found in 2-years follow-up. This report includes clinical, radiologic, histologic diagnostic, and surgical challenges in an unexpected lesion and a review of the literature.<\/jats:p>","DOI":"10.7547\/19-059","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T21:00:03Z","timestamp":1596142803000},"source":"Crossref","is-referenced-by-count":2,"title":["Giant Cell Tumor of Tendon Sheath with Tarsal Bones and Intertarsal Joint Invasion: A Case Report"],"prefix":"10.3390","volume":"110","author":[{"given":"Qi-Fang","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yu","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-Long","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"i8750-7315-110-3-Article_15-b01","series-title":"Enzinger and Weiss's Soft Tissue Tumors","author":"Sharon","year":"2001","unstructured":"Sharon\n              WWJ:\n            \n          \n          \n            Enzinger and Weiss's Soft Tissue Tumors\n          ,\n\t\t\t\t\t4th Ed, p 1037, Mosby, St. Louis,2001."},{"key":"i8750-7315-110-3-Article_15-b02","series-title":"Hand (N Y)","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1007\/s11552-011-9341-9","article-title":"Giant cell tumour of tendon sheath of the digits: a systematic review","volume":"6","author":"Fotiadis","year":"2011","unstructured":"Fotiadis\n              E\n            \n            \n              Papadopoulos\n              A\n            \n            \n              Svarnas\n              T\n            \n            :\n\t\t\t\t\t\n          Giant cell tumour of tendon sheath of the digits: a systematic review.\n\t\t\t\t\tHand (N Y)6:\n\t\t\t\t\t244,\n\t\t\t\t\t2011.\n\t\t\t\t10.1007\/s11552-011-9341-9"},{"key":"i8750-7315-110-3-Article_15-b03","series-title":"BMC Musculoskelet Disord","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12891-016-1050-7","article-title":"Tenosynovial giant cell tumors in unusual locations detected by positron emission tomography imaging confused with malignant tumors: report of two cases","volume":"17","author":"Takeuchi","year":"2016","unstructured":"Takeuchi\n              A\n            \n            \n              Yamamoto\n              M\n            \n            \n              Hayashi\n              K\n            \n            :\n\t\t\t\t\t\n          Tenosynovial giant cell tumors in unusual locations detected by positron emission tomography imaging confused with malignant tumors: report of two cases.\n\t\t\t\t\tBMC Musculoskelet Disord17: 180,\n\t\t\t\t\t2016.\n\t\t\t\t2711372110.1186\/s12891-016-1050-7http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000375032500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3"},{"key":"i8750-7315-110-3-Article_15-b04","series-title":"Proc Natl Acad Sci USA","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1073\/pnas.0507321103","article-title":"A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells","volume":"103","author":"West","year":"2006","unstructured":"West\n              RB\n            \n            \n              Rubin\n              BP\n            \n            \n              Miller\n              MA\n            \n            :\n\t\t\t\t\t\n          A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells.\n\t\t\t\t\tProc Natl Acad Sci USA103: 690,\n\t\t\t\t\t2006.\n\t\t\t\t10.1073\/pnas.0507321103"},{"key":"i8750-7315-110-3-Article_15-b05","series-title":"Clin Orthop","first-page":"140","article-title":"Giant-cell tumor of tendon sheath (benign synovioma) in the hand: evaluation of 56 cases","volume":"15","author":"Phalen","year":"1959","unstructured":"Phalen\n              GS\n            \n            \n              McCormack\n              LJ\n            \n            \n              Gazale\n              WJ:\n            \n          \n          Giant-cell tumor of tendon sheath (benign synovioma) in the hand: evaluation of 56 cases.\n\t\t\t\t\tClin Orthop15: 140,\n\t\t\t\t\t1959.\n\t\t\t\t14432560"},{"key":"i8750-7315-110-3-Article_15-b06","series-title":"J Hand Surg Br","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1054\/jhsb.2000.0522","article-title":"Giant cell tumours of tendon sheath: classification and recurrence rate","volume":"26","author":"Al-Qattan","year":"2001","unstructured":"Al-Qattan\n              MM:\n            \n          \n          Giant cell tumours of tendon sheath: classification and recurrence rate.\n\t\t\t\t\tJ Hand Surg Br26: 72,\n\t\t\t\t\t2001.\n\t\t\t\t1116202410.1054\/jhsb.2000.0522"},{"key":"i8750-7315-110-3-Article_15-b07","series-title":"Arthritis Res Ther","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/s13075-016-1104-0","article-title":"Do early life factors affect the development of knee osteoarthritis in later life: a narrative review","volume":"18","author":"Antony","year":"2016","unstructured":"Antony\n              B\n            \n            \n              Jones\n              G\n            \n            \n              Jin\n              X\n            \n            :\n\t\t\t\t\t\n          Do early life factors affect the development of knee osteoarthritis in later life: a narrative review.\n\t\t\t\t\tArthritis Res Ther18: 202,\n\t\t\t\t\t2016.\n\t\t\t\thttp:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383162400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1186\/s13075-016-1104-027623622"},{"key":"i8750-7315-110-3-Article_15-b08","series-title":"JAPMA","first-page":"249","article-title":"Giant cell tumor of the tendon sheath around the foot and ankle. A report of three cases and a literature review","volume":"105","author":"Vargaonkar","year":"2015","unstructured":"Vargaonkar\n              G\n            \n            \n              Singh\n              V\n            \n            \n              Arora\n              S\n            \n            :\n\t\t\t\t\t\n          Giant cell tumor of the tendon sheath around the foot and ankle. A report of three cases and a literature review.\n\t\t\t\t\tJAPMA105: 249,\n\t\t\t\t\t2015."},{"key":"i8750-7315-110-3-Article_15-b09","series-title":"Radiol Med","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s11547-015-0520-6","article-title":"Giant cell tumour of tendon sheath with bone invasion in extremities: analysis of clinical and imaging findings","volume":"120","author":"Wang","year":"2015","unstructured":"Wang\n              CS\n            \n            \n              Duan\n              Q\n            \n            \n              Xue\n              YJ\n            \n            :\n\t\t\t\t\t\n          Giant cell tumour of tendon sheath with bone invasion in extremities: analysis of clinical and imaging findings.\n\t\t\t\t\tRadiol Med120: 745,\n\t\t\t\t\t2015.\n\t\t\t\t25698301http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361490200009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1007\/s11547-015-0520-6"},{"key":"i8750-7315-110-3-Article_15-b10","series-title":"J Hand Surg Am","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/S0363-5023(05)80148-0","article-title":"Giant cell tumor of tendon sheath with intraosseous invasion: a case report","volume":"20","author":"Booth","year":"1995","unstructured":"Booth\n              KC\n            \n            \n              Campbell\n              GS\n            \n            \n              Chase\n              DR:\n            \n          \n          Giant cell tumor of tendon sheath with intraosseous invasion: a case report.\n\t\t\t\t\tJ Hand Surg Am20: 1000,\n\t\t\t\t\t1995.\n\t\t\t\t10.1016\/S0363-5023(05)80148-08583046"},{"key":"i8750-7315-110-3-Article_15-b11","series-title":"Foot Ankle Int","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1177\/107110079601700810","article-title":"Aneurysmal bone cyst and giant cell tumor of the foot","volume":"17","author":"Casadei","year":"1996","unstructured":"Casadei\n              R\n            \n            \n              Ruggieri\n              P\n            \n            \n              Moscato\n              M\n            \n            :\n\t\t\t\t\t\n          Aneurysmal bone cyst and giant cell tumor of the foot.\n\t\t\t\t\tFoot Ankle Int17: 487,\n\t\t\t\t\t1996.\n\t\t\t\t886302910.1177\/107110079601700810"},{"key":"i8750-7315-110-3-Article_15-b12","series-title":"Br J Radiol","doi-asserted-by":"publisher","first-page":"20150528","DOI":"10.1259\/bjr.20150528","article-title":"MRI and thallium features of pigmented villonodular synovitis and giant cell tumours of tendon sheaths: a retrospective single centre study of imaging and literature review","volume":"88","author":"Lynskey","year":"2015","unstructured":"Lynskey\n              SJ\n            \n            \n              Pianta\n              MJ:\n            \n          \n          MRI and thallium features of pigmented villonodular synovitis and giant cell tumours of tendon sheaths: a retrospective single centre study of imaging and literature review.\n\t\t\t\t\tBr J Radiol88: 20150528,\n\t\t\t\t\t2015.\n\t\t\t\t2644054810.1259\/bjr.20150528http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000366681800018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3"},{"key":"i8750-7315-110-3-Article_15-b13","series-title":"Zhongguo Gu Shang","first-page":"988","article-title":"Analysis on recurrence factors associate with giant cell tumor of tendon sheath in upper extremity [in Chinese]","volume":"24","author":"Liu","year":"2011","unstructured":"Liu\n              YB\n            \n            \n              Lin\n              DS\n            \n            \n              Wang\n              J\n            \n            :\n\t\t\t\t\t\n          Analysis on recurrence factors associate with giant cell tumor of tendon sheath in upper extremity [in Chinese].\n\t\t\t\t\tZhongguo Gu Shang24: 988,\n\t\t\t\t\t2011.\n\t\t\t\t22276505"},{"key":"i8750-7315-110-3-Article_15-b14","series-title":"Rev Fac Cien Med Univ Nac Cordoba","first-page":"258","article-title":"Results after surgical treatment of giant cell tumor [in Spanish]","volume":"73","author":"Aguilar Ezquerra","year":"2016","unstructured":"Aguilar Ezquerra\n              A\n            \n            \n              Lopez Subias\n              J\n            \n            \n              Lillo-Ad\u00e1n\n              M\n            \n            :\n\t\t\t\t\t\n          Results after surgical treatment of giant cell tumor [in Spanish].\n\t\t\t\t\tRev Fac Cien Med Univ Nac Cordoba73: 258,\n\t\t\t\t\t2016.\n\t\t\t\t28152367"},{"key":"i8750-7315-110-3-Article_15-b15","series-title":"J Foot Ankle Surg","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1053\/j.jfas.2011.09.004","article-title":"Matrix-associated autologous chondrocyte transplantation combined with iliac crest bone graft for reconstruction of talus necrosis due to villonodular synovitis","volume":"51","author":"Dickschas","year":"2012","unstructured":"Dickschas\n              J\n            \n            \n              Welsch\n              G\n            \n            \n              Strecker\n              W\n            \n            :\n\t\t\t\t\t\n          Matrix-associated autologous chondrocyte transplantation combined with iliac crest bone graft for reconstruction of talus necrosis due to villonodular synovitis.\n\t\t\t\t\tJ Foot Ankle Surg51: 87,\n\t\t\t\t\t2012.\n\t\t\t\thttp:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000298372100019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f32210417110.1053\/j.jfas.2011.09.004"},{"key":"i8750-7315-110-3-Article_15-b16","series-title":"Foot Ankle Spec","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1177\/1938640011412952","article-title":"Excision of extensive midfoot pigmented villonodular synovitis with microvascular anastamosis of iliac crest bone graft using external fixation: a case report","volume":"4","author":"Oloff","year":"2011","unstructured":"Oloff\n              L\n            \n            \n              Miller\n              K:\n            \n          \n          Excision of extensive midfoot pigmented villonodular synovitis with microvascular anastamosis of iliac crest bone graft using external fixation: a case report.\n\t\t\t\t\tFoot Ankle Spec4: 301,\n\t\t\t\t\t2011.\n\t\t\t\t10.1177\/193864001141295221926367"},{"key":"i8750-7315-110-3-Article_15-b17","series-title":"BMC Surg","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12893-019-0491-y","article-title":"A three-dimensional printed porous implant combined with bone grafting following curettage of a subchondral giant cell tumour of the proximal tibia: a case report","volume":"19","author":"Lu","year":"2019","unstructured":"Lu\n              M\n            \n            \n              Wang\n              J\n            \n            \n              Tang\n              F\n            \n            :\n\t\t\t\t\t\n          A three-dimensional printed porous implant combined with bone grafting following curettage of a subchondral giant cell tumour of the proximal tibia: a case report.\n\t\t\t\t\tBMC Surg19: 29,\n\t\t\t\t\t2019.\n\t\t\t\t10.1186\/s12893-019-0491-yhttp:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000460042400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f330819160"},{"key":"i8750-7315-110-3-Article_15-b18","series-title":"Anat Cell Biol","doi-asserted-by":"publisher","first-page":"93","DOI":"10.5115\/acb.2017.50.2.93","article-title":"Vascular foramina of navicular bone: a morphometric study","volume":"50","author":"Prathapamchandra","year":"2017","unstructured":"Prathapamchandra\n              V\n            \n            \n              Ravichandran\n              P\n            \n            \n              Shanmugasundaram\n              J\n            \n            :\n\t\t\t\t\t\n          Vascular foramina of navicular bone: a morphometric study.\n\t\t\t\t\tAnat Cell Biol50: 93,\n\t\t\t\t\t2017.\n\t\t\t\thttp:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000448072100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.5115\/acb.2017.50.2.9328713611"},{"key":"i8750-7315-110-3-Article_15-b19","series-title":"Foot Ankle Int","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1177\/1071100713518505","article-title":"Intraosseous and extraosseous blood supply to the medial cuneiform: implications for dorsal opening wedge plantarflexion osteotomy","volume":"35","author":"Kraus","year":"2014","unstructured":"Kraus\n              JC\n            \n            \n              McKeon\n              KE\n            \n            \n              Johnson\n              JE\n            \n            :\n\t\t\t\t\t\n          Intraosseous and extraosseous blood supply to the medial cuneiform: implications for dorsal opening wedge plantarflexion osteotomy.\n\t\t\t\t\tFoot Ankle Int35: 394,\n\t\t\t\t\t2014.\n\t\t\t\thttp:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339328800013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f32437567210.1177\/1071100713518505"}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/110\/3\/i8750-7315-110-3-article_15.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/japma\/article-pdf\/doi\/10.7547\/19-059\/2558792\/i8750-7315-110-3-article_15.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/110\/3\/i8750-7315-110-3-article_15.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/110\/3\/i8750-7315-110-3-article_15.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:17:56Z","timestamp":1783505876000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/110\/3\/19059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":19,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.7547\/19-059","relation":{},"ISSN":["8750-7315"],"issn-type":[{"value":"8750-7315","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]}}}