{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:42Z","timestamp":1783509282711,"version":"3.55.0"},"reference-count":28,"publisher":"MDPI AG","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5]]},"abstract":"Following partial bone resection for osteomyelitis, continued osteomyelitis in the remaining bone is common and problematic. Shortcomings in available surgical techniques to combat this also contribute to this problem. Presented are two case studies using a solution to this problem with a different type of bone void filler as a carrier vehicle for delivering antibiotics into the remaining infected bone to eradicate any residual bacteria in the remaining bone.<\/jats:p>","DOI":"10.7547\/19-157","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T17:01:12Z","timestamp":1624035672000},"source":"Crossref","is-referenced-by-count":0,"title":["Improving Outcomes for Osteomyelitis After Partial Bone Resection: A Preliminary Report"],"prefix":"10.3390","volume":"111","author":[{"given":"Jeffrey C.","family":"Karr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"i8750-7315-111-3-Article_23-b01","series-title":"J Foot Ankle Surg","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1053\/j.jfas.2012.06.017","article-title":"Rate of residual osteomyelitis after partial foot amputation in diabetic patients: a standardized method for evaluating bone margins with intraoperative culture","volume":"51","author":"Atway","year":"2012","unstructured":"Atway\n S\n \n \n Nerone\n VS\n \n \n Springer\n KD\n \n :\n \n Rate of residual osteomyelitis after partial foot amputation in diabetic patients: a standardized method for evaluating bone margins with intraoperative culture.\n\t\t\t\t\tJ Foot Ankle Surg51: 749,\n\t\t\t\t\t2012.\n\t\t\t\t10.1053\/j.jfas.2012.06.01722819618"},{"issue":"(suppl 1)","key":"i8750-7315-111-3-Article_23-b02","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"190S","DOI":"10.1097\/PRS.0b013e3182025070","article-title":"Surgical treatment of osteomyelitis","volume":"127","author":"Cierny","year":"2011","unstructured":"Cierny\n G III:\n \n \n Surgical treatment of osteomyelitis.\n\t\t\t\t\tPlast Reconstr Surg127(suppl 1): 190S,\n\t\t\t\t\t2011.\n\t\t\t\t10.1097\/PRS.0b013e318202507021200291"},{"key":"i8750-7315-111-3-Article_23-b03","series-title":"Diabetes Care","doi-asserted-by":"publisher","first-page":"566","DOI":"10.2337\/diacare.29.03.06.dc05-1992","article-title":"Risk of reamputation in diabetic patients stratified by limb and level of amputation: a 10-year observation","volume":"29","author":"Izumi","year":"2006","unstructured":"Izumi\n Y\n \n \n Satterfield\n K\n \n \n Lee\n S\n \n :\n \n Risk of reamputation in diabetic patients stratified by limb and level of amputation: a 10-year observation.\n\t\t\t\t\tDiabetes Care29: 566,\n\t\t\t\t\t2006.\n\t\t\t\t10.2337\/diacare.29.03.06.dc05-199216505507"},{"key":"i8750-7315-111-3-Article_23-b04","series-title":"J Orthop Res","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1002\/jor.1100110503","article-title":"In-vitro pharmockinetics of antibiotic release from locally implantable materials","volume":"11","author":"Miclau","year":"1993","unstructured":"Miclau\n T\n \n \n Dahners\n LE\n \n \n Lindsey\n RW:\n \n \n In-vitro pharmockinetics of antibiotic release from locally implantable materials.\n\t\t\t\t\tJ Orthop Res11: 627,\n\t\t\t\t\t1993.\n\t\t\t\t10.1002\/jor.11001105038410461"},{"key":"i8750-7315-111-3-Article_23-b05","series-title":"Acta Orthop Scand","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3109\/17453679708996270","article-title":"How I do it: chronic osteomyelitis","volume":"68","author":"Walenkamp","year":"1997","unstructured":"Walenkamp\n GHIM:\n \n \n How I do it: chronic osteomyelitis.\n\t\t\t\t\tActa Orthop Scand68: 497,\n\t\t\t\t\t1997.\n\t\t\t\t10.3109\/17453679708996270"},{"key":"i8750-7315-111-3-Article_23-b06","series-title":"Bone","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S8756-3282(02)00950-X","article-title":"Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro","volume":"32","author":"Reffitt","year":"2003","unstructured":"Reffitt\n DM\n \n \n Ogston\n N\n \n \n Jugdaohsingh\n R\n \n :\n \n Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro.\n\t\t\t\t\tBone32: 127,\n\t\t\t\t\t2003.\n\t\t\t\t10.1016\/S8756-3282(02)00950-X12633784"},{"key":"i8750-7315-111-3-Article_23-b07","series-title":"J Bone Miner Res","first-page":"1281","article-title":"Zeolite A increases proliferation, differentiation, and transforming growth factor \u03b2 production in normal adult human osteoblast-like cells in vitro","volume":"7","author":"Keeting","year":"1992","unstructured":"Keeting\n PE\n \n \n Oursler\n MJ\n \n \n Wiegand\n KE\n \n :\n \n Zeolite A increases proliferation, differentiation, and transforming growth factor \u03b2 production in normal adult human osteoblast-like cells in vitro.\n\t\t\t\t\tJ Bone Miner Res7: 1281,\n\t\t\t\t\t1992.\n\t\t\t\t1334616"},{"key":"i8750-7315-111-3-Article_23-b08","series-title":"Surf Coat Technol","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.1016\/j.surfcoat.2012.05.019","article-title":"Effect of a bioactive glass-ceramic on the apatite nucleation on titanium surface modified by micro-arc oxidation","volume":"206","author":"Soares","year":"2012","unstructured":"Soares\n P\n \n \n Laurindo\n CAH\n \n \n Torres\n RD\n \n :\n \n Effect of a bioactive glass-ceramic on the apatite nucleation on titanium surface modified by micro-arc oxidation.\n\t\t\t\t\tSurf Coat Technol206: 4601,\n\t\t\t\t\t2012.\n\t\t\t\t10.1016\/j.surfcoat.2012.05.019"},{"key":"i8750-7315-111-3-Article_23-b09","series-title":"J Dent Res","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1177\/00220345920710030601","article-title":"Silica-induced precipitation of calcium phosphate in the presence of inhibitors of hydroxyapatite formation","volume":"71","author":"Damen","year":"1992","unstructured":"Damen\n JJM\n \n \n Ten Cate\n JM:\n \n \n Silica-induced precipitation of calcium phosphate in the presence of inhibitors of hydroxyapatite formation.\n\t\t\t\t\tJ Dent Res71: 453,\n\t\t\t\t\t1992.\n\t\t\t\t131534710.1177\/00220345920710030601"},{"key":"i8750-7315-111-3-Article_23-b10","series-title":"Biomaterials","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1016\/j.biomaterials.2006.01.017","article-title":"How useful is SBF in predicting in vivo bone bioactivity?","volume":"27","author":"Kokubo","year":"2006","unstructured":"Kokubo\n T\n \n \n Takadama\n H:\n \n \n How useful is SBF in predicting in vivo bone bioactivity?\n Biomaterials\n 27\n : \n 2907,\n\t\t\t\t\t2006.\n\t\t\t\t10.1016\/j.biomaterials.2006.01.01716448693"},{"key":"i8750-7315-111-3-Article_23-b11","series-title":"J Biomed Mater Res","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/jbm.820150308","article-title":"Adsorption characteristics of plasma fibronectin in relationship to biological activity","volume":"15","author":"Grinnell","year":"1981","unstructured":"Grinnell\n F\n \n \n Feld\n MK:\n \n \n Adsorption characteristics of plasma fibronectin in relationship to biological activity.\n\t\t\t\t\tJ Biomed Mater Res15: 363,\n\t\t\t\t\t1981.\n\t\t\t\t734827110.1002\/jbm.820150308"},{"key":"i8750-7315-111-3-Article_23-b12","series-title":"Biomaterials","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1016\/S0142-9612(99)00181-7","article-title":"Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function","volume":"20","author":"Ducheyne","year":"1999","unstructured":"Ducheyne\n P\n \n \n Qiu\n Q:\n \n \n Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function.\n\t\t\t\t\tBiomaterials20: 2287,\n\t\t\t\t\t1999.\n\t\t\t\t10.1016\/S0142-9612(99)00181-7"},{"key":"i8750-7315-111-3-Article_23-b13","series-title":"Micron","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.micron.2006.03.006","article-title":"Nanoscale characterization of the interface between bone and hydroxyapatite implants and the effect of silicon on bone apposition","volume":"37","author":"Porter","year":"2006","unstructured":"Porter\n AE:\n \n \n Nanoscale characterization of the interface between bone and hydroxyapatite implants and the effect of silicon on bone apposition.\n\t\t\t\t\tMicron37: 681,\n\t\t\t\t\t2006.\n\t\t\t\t10.1016\/j.micron.2006.03.006"},{"key":"i8750-7315-111-3-Article_23-b14","series-title":"J Biomed Mater Res","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/jbm.10270","article-title":"Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants","volume":"62","author":"Zreiqat","year":"2002","unstructured":"Zreiqat\n H\n \n \n Howlett\n CR\n \n \n Zannettino\n A\n \n :\n \n Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants.\n\t\t\t\t\tJ Biomed Mater Res62: 175,\n\t\t\t\t\t2002.\n\t\t\t\t10.1002\/jbm.1027012209937"},{"key":"i8750-7315-111-3-Article_23-b15","series-title":"Br J Oral Maxillofac Surg","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/0266-4356(90)90033-H","article-title":"Gentamicin impregnated polymethylmethacrylate (PMMA) beads in the treatment of primary chronic osteomyelitis of the mandible","volume":"28","author":"Grime","year":"1990","unstructured":"Grime\n PD\n \n \n Bowerman\n JE\n \n \n Weller\n PJ:\n \n \n Gentamicin impregnated polymethylmethacrylate (PMMA) beads in the treatment of primary chronic osteomyelitis of the mandible.\n\t\t\t\t\tBr J Oral Maxillofac Surg28: 367,\n\t\t\t\t\t1990.\n\t\t\t\t227903610.1016\/0266-4356(90)90033-H"},{"key":"i8750-7315-111-3-Article_23-b16","series-title":"Clin Orthop Rel Res","first-page":"89","article-title":"Use of antibiotic-containing bone cement","volume":"190","author":"Murray","year":"1984","unstructured":"Murray\n WR:\n \n \n Use of antibiotic-containing bone cement.\n\t\t\t\t\tClin Orthop Rel Res190: 89,\n\t\t\t\t\t1984."},{"key":"i8750-7315-111-3-Article_23-b17","series-title":"Clin Orthop Rel Res","first-page":"173","article-title":"Prophylaxis with systemic antibiotics versus gentamicin bone cement in total hip arthroplasty. A 5-year survey of 1688 hips","volume":"253","author":"Josefsson","year":"1990","unstructured":"Josefsson\n G\n \n \n Gudmundsson\n G\n \n \n Kolmert\n L\n \n :\n \n Prophylaxis with systemic antibiotics versus gentamicin bone cement in total hip arthroplasty. A 5-year survey of 1688 hips.\n\t\t\t\t\tClin Orthop Rel Res253: 173,\n\t\t\t\t\t1990."},{"key":"i8750-7315-111-3-Article_23-b18","series-title":"Reconstr Surg Traumatol","first-page":"36","article-title":"Local antibiotic therapy using gentamicin-PMMA chains in post-traumatic bone infections. Short and long-term results","volume":"20","author":"Jenny","year":"1988","unstructured":"Jenny\n G:\n \n \n Local antibiotic therapy using gentamicin-PMMA chains in post-traumatic bone infections. Short and long-term results.\n\t\t\t\t\tReconstr Surg Traumatol20: 36,\n\t\t\t\t\t1988."},{"key":"i8750-7315-111-3-Article_23-b19","series-title":"Am J Surg","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/0002-9610(89)90597-7","article-title":"Antibiotic beads in the management of surgical infections","volume":"157","author":"Calhoun","year":"1989","unstructured":"Calhoun\n JH\n \n \n Mader\n JT:\n \n \n Antibiotic beads in the management of surgical infections.\n\t\t\t\t\tAm J Surg157: 443,\n\t\t\t\t\t1989.\n\t\t\t\t264888610.1016\/0002-9610(89)90597-7"},{"key":"i8750-7315-111-3-Article_23-b20","series-title":"J Bone Joint Surg Br","first-page":"111","article-title":"Experimental implant-related osteomyelitis treated by antibiotic-calium hydroxyapatite ceramic composites","volume":"75","author":"Korkusuz","year":"1993","unstructured":"Korkusuz\n F\n \n \n Uchida\n A\n \n \n Shinto\n Y\n \n :\n \n Experimental implant-related osteomyelitis treated by antibiotic-calium hydroxyapatite ceramic composites.\n\t\t\t\t\tJ Bone Joint Surg Br75: 111,\n\t\t\t\t\t1993.\n\t\t\t\t8380599"},{"key":"i8750-7315-111-3-Article_23-b21","series-title":"J Bone Joint Surg Br","first-page":"600","article-title":"Calcium hydroxyapatite ceramic used as a delivery system for antibiotics","volume":"74","author":"Shinto","year":"1992","unstructured":"Shinto\n Y\n \n \n Uchida\n A\n \n \n Korkusuz\n F\n \n :\n \n Calcium hydroxyapatite ceramic used as a delivery system for antibiotics.\n\t\t\t\t\tJ Bone Joint Surg Br74: 600,\n\t\t\t\t\t1992.\n\t\t\t\t1320622"},{"key":"i8750-7315-111-3-Article_23-b22","series-title":"Diabetes Care","doi-asserted-by":"publisher","first-page":"e79","DOI":"10.2337\/dc14-3100","article-title":"Use of highly purified synthetic calcium sulfate impregnated with antibiotics for the management of diabetic foot ulcers complicated by osteomyelitis","volume":"38","author":"Jogia","year":"2015","unstructured":"Jogia\n RM\n \n \n Modha\n DE\n \n \n Nisal\n K\n \n :\n \n Use of highly purified synthetic calcium sulfate impregnated with antibiotics for the management of diabetic foot ulcers complicated by osteomyelitis.\n\t\t\t\t\tDiabetes Care38: e79,\n\t\t\t\t\t2015.\n\t\t\t\t2590816310.2337\/dc14-3100"},{"key":"i8750-7315-111-3-Article_23-b23","series-title":"JAPMA","first-page":"259","article-title":"Management in the wound-care center outpatient setting of a diabetic patient with forefoot osteomyelitis using Cerament Bone Void Filler impregnated with vancomycin: off-label use","volume":"101","author":"Karr","year":"2011","unstructured":"Karr\n JC:\n \n \n Management in the wound-care center outpatient setting of a diabetic patient with forefoot osteomyelitis using Cerament Bone Void Filler impregnated with vancomycin: off-label use.\n\t\t\t\t\tJAPMA101: 259,\n\t\t\t\t\t2011."},{"key":"i8750-7315-111-3-Article_23-b24","series-title":"Antimicrob Agents Chemother","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1128\/AAC.49.4.1502-1508.2005","article-title":"Efficacy of ciprofloxacin-releasing bioabsorbable osteoconductive bone defect filler for treatment of experimental osteomyelitis due to Staphylococcus aureus","volume":"49","author":"Koort","year":"2005","unstructured":"Koort\n JK\n \n \n M\u00e4kinen\n TJ\n \n \n Suokas\n E\n \n :\n \n Efficacy of ciprofloxacin-releasing bioabsorbable osteoconductive bone defect filler for treatment of experimental osteomyelitis due to Staphylococcus aureus.\n\t\t\t\t\tAntimicrob Agents Chemother49: 1502,\n\t\t\t\t\t2005.\n\t\t\t\t10.1128\/AAC.49.4.1502-1508.200515793132"},{"key":"i8750-7315-111-3-Article_23-b25","series-title":"J Bone Joint Surg Am","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.2106\/00004623-199410000-00009","article-title":"Polylatide\/polyglycolide antibiotic implants in the treatment of osteomyelitis. A canine model","volume":"76","author":"Garvin","year":"1994","unstructured":"Garvin\n KL\n \n \n Miyano\n JA\n \n \n Robinson\n D\n \n :\n \n Polylatide\/polyglycolide antibiotic implants in the treatment of osteomyelitis. A canine model.\n\t\t\t\t\tJ Bone Joint Surg Am76: 1500,\n\t\t\t\t\t1994.\n\t\t\t\t10.2106\/00004623-199410000-00009"},{"key":"i8750-7315-111-3-Article_23-b26","series-title":"Eur J Surg","first-page":"17","article-title":"Local treatment of bone and soft tissue infections with the collagen-gentamicin sponge","volume":"163","author":"Stemberger","year":"1997","unstructured":"Stemberger\n A\n \n \n Grimm\n AH\n \n \n Bader\n F\n \n :\n \n Local treatment of bone and soft tissue infections with the collagen-gentamicin sponge.\n\t\t\t\t\tEur J Surg163: 17,\n\t\t\t\t\t1997."},{"key":"i8750-7315-111-3-Article_23-b27","series-title":"Biomaterials","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1016\/0142-9612(96)87654-X","article-title":"Comparative investigation of drug delivery of collagen implants saturated in antibiotic solutions and a sponge containing gentamicin","volume":"17","author":"Wachol-Drewek","year":"1996","unstructured":"Wachol-Drewek\n Z\n \n \n Pfeiffer\n M\n \n \n Scholl\n E:\n \n \n Comparative investigation of drug delivery of collagen implants saturated in antibiotic solutions and a sponge containing gentamicin.\n\t\t\t\t\tBiomaterials17: 1733,\n\t\t\t\t\t1996.\n\t\t\t\t10.1016\/0142-9612(96)87654-X"},{"key":"i8750-7315-111-3-Article_23-b28","series-title":"Surg Infect","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1089\/sur.2016.189","article-title":"Optimizing vancomycin release from calcium phosphate-based cement by carboxymethyl cellulose for prevention of osteomyelitis","volume":"18","author":"Lin","year":"2017","unstructured":"Lin\n BR\n \n \n Caldwell\n C\n \n \n Bhaduri\n S\n \n :\n \n Optimizing vancomycin release from calcium phosphate-based cement by carboxymethyl cellulose for prevention of osteomyelitis.\n\t\t\t\t\tSurg Infect18: 221,\n\t\t\t\t\t2017.\n\t\t\t\t10.1089\/sur.2016.189"}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/111\/3\/i8750-7315-111-3-article_23.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/japma\/article-pdf\/doi\/10.7547\/19-157\/2847487\/i8750-7315-111-3-article_23.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/111\/3\/i8750-7315-111-3-article_23.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/111\/3\/i8750-7315-111-3-article_23.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:18:18Z","timestamp":1783505898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/111\/3\/19157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":28,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.7547\/19-157","relation":{},"ISSN":["8750-7315"],"issn-type":[{"value":"8750-7315","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}