{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:32Z","timestamp":1783509272119,"version":"3.55.0"},"reference-count":16,"publisher":"MDPI AG","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec id=\"st1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous study indicates that pharmacologic antithrombotic therapy may be an inhibitory factor for wound healing and should merit consideration among the other core factors in wound healing optimization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study provides a retrospective analysis of the effect of antithrombotic therapy on wound healing rates of uncomplicated diabetic foot ulcerations. Wounds treated with standard of care in the presence of clinical anticoagulation were compared to control wounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results indicate a statistically significant negative correlation between antithrombotic therapy and diabetic foot wound healing rate. This represents the first study focusing on this correlation in the uncomplicated diabetic foot wound.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This retrospective study demonstrates that antithrombotic therapy has a statistically significant negative effect on healing rates of uncomplicated diabetic foot ulcerations. Both wound area and depth improvement over 4 weeks was significantly better in treated patients who were not on antithrombotic therapy for comorbidity not associated with peripheral arterial disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7547\/20-075","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T16:02:13Z","timestamp":1630684933000},"source":"Crossref","is-referenced-by-count":1,"title":["Healing Rate of Diabetic Foot Wounds When Treated with Serial Debridement in the Presence of Antithrombotic Therapy"],"prefix":"10.3390","volume":"111","author":[{"given":"Jack","family":"Route","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"i8750-7315-111-4-Article_4-b01","series-title":"Bull NY Acad Med","first-page":"1159","article-title":"The neuropathic foot of the diabetic","volume":"52","author":"Lippman","year":"1976","unstructured":"Lippman\n              HI\n            \n            \n              Perotto\n              A\n            \n            \n              Ferrar\n              R:\n            \n          \n          The neuropathic foot of the diabetic.\n\t\t\t\t\tBull NY Acad Med52: \n\t\t\t\t\t1159,\n\t\t\t\t\t1976."},{"key":"i8750-7315-111-4-Article_4-b02","series-title":"Diabetes Care","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.2337\/diacare.25.8.1444","article-title":"Intrinsic muscle atrophy and toe deformity in the diabetic neuropathic foot: a magnetic resonance imaging study","volume":"25","author":"Bus","year":"2002","unstructured":"Bus\n              SA\n            \n            \n              Yang\n              QX\n            \n            \n              Wang\n              JH\n            \n            :\n\t\t\t\t\t\n          Intrinsic muscle atrophy and toe deformity in the diabetic neuropathic foot: a magnetic resonance imaging study.\n\t\t\t\t\tDiabetes Care25: \n\t\t\t\t\t1444,\n\t\t\t\t\t2002.\n\t\t\t\t10.2337\/diacare.25.8.144412145248"},{"key":"i8750-7315-111-4-Article_4-b03","series-title":"Diabetes Care","doi-asserted-by":"publisher","first-page":"26","DOI":"10.2337\/dc07-1300","article-title":"Prediction of healing for postoperative diabetic foot wounds based on early wound area progression","volume":"31","author":"Lavery","year":"2008","unstructured":"Lavery\n              LA\n            \n            \n              Barnes\n              SA\n            \n            \n              Keith\n              MS\n            \n            :\n\t\t\t\t\t\n          Prediction of healing for postoperative diabetic foot wounds based on early wound area progression.\n\t\t\t\t\tDiabetes Care31: \n\t\t\t\t\t26,\n\t\t\t\t\t2008.\n\t\t\t\t17934156http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000252178900006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.2337\/dc07-1300"},{"key":"i8750-7315-111-4-Article_4-b04","series-title":"Ostomy Wound Manage","first-page":"44","article-title":"A post-hoc analysis of reduction in diabetic foot ulcer size at 4 weeks as a predictor of healing by 12 weeks","volume":"56","author":"Snyder","year":"2010","unstructured":"Snyder\n              RJ\n            \n            \n              Cardinal\n              M\n            \n            \n              Dauphin\u00e9e\n              DM\n            \n            :\n\t\t\t\t\t\n          A post-hoc analysis of reduction in diabetic foot ulcer size at 4 weeks as a predictor of healing by 12 weeks.\n\t\t\t\t\tOstomy Wound Manage56: \n\t\t\t\t\t44,\n\t\t\t\t\t2010.\n\t\t\t\t20368673"},{"key":"i8750-7315-111-4-Article_4-b05","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1001\/jama.2015.10029","article-title":"Prevalence of and trends in diabetes among adults in the United States, 1988-2012","volume":"314","author":"Menke","year":"2015","unstructured":"Menke\n              A\n            \n            \n              Casagrande\n              S\n            \n            \n              Geiss\n              L\n            \n            :\n\t\t\t\t\t\n          Prevalence of and trends in diabetes among adults in the United States, 1988-2012.\n\t\t\t\t\tJAMA314: \n\t\t\t\t\t1021,\n\t\t\t\t\t2015.\n\t\t\t\t10.1001\/jama.2015.10029http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360840700014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f326348752"},{"issue":"(suppl)","key":"i8750-7315-111-4-Article_4-b06","series-title":"J Vasc Surg","doi-asserted-by":"publisher","first-page":"28S","DOI":"10.1016\/j.jvs.2010.06.005","article-title":"What you can't feel can hurt you","volume":"52","author":"Boulton","year":"2010","unstructured":"Boulton\n              AJ:\n            \n          \n          What you can't feel can hurt you.\n\t\t\t\t\tJ Vasc Surg52(suppl): 28S,\n\t\t\t\t\t2010.\n\t\t\t\thttp:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000281570200005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f32080493010.1016\/j.jvs.2010.06.005"},{"key":"i8750-7315-111-4-Article_4-b07","series-title":"Diabetes Care","first-page":"2161","article-title":"Preventive foot care in people with diabetes","volume":"21","author":"Mayfield","year":"1988","unstructured":"Mayfield\n              JA\n            \n            \n              Reiber\n              GE\n            \n            \n              Sanders\n              LJ\n            \n            :\n\t\t\t\t\t\n          Preventive foot care in people with diabetes.\n\t\t\t\t\tDiabetes Care21: \n\t\t\t\t\t2161,\n\t\t\t\t\t1988."},{"key":"i8750-7315-111-4-Article_4-b08","series-title":"Textbook of Diabetic Neuropathy","first-page":"64","article-title":"\u201cCosts of Foot Ulcer and Lower-Extremity 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Diabetes Care","first-page":"1354","article-title":"7\u20138 April 1999, Boston, Massachusetts","volume":"22","year":"1999","unstructured":"Consensus Development Conference on diabetic foot wound care:\n          7\u20138 April 1999, Boston, Massachusetts.\n\t\t\t\t\tAmerican Diabetes Association. 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