{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:52Z","timestamp":1783509292024,"version":"3.55.0"},"reference-count":21,"publisher":"MDPI AG","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Acral lentiginous melanoma is commonly misdiagnosed, and when detected late it portends a poor prognosis. Acral lentiginous melanoma can be mistaken for verruca, pyogenic granuloma, poroma, an ulcer, or other benign skin conditions. Patients with acral skin growths often present initially to a podiatric physician or their primary care physician. It is at this point when the growth is triaged as benign or potentially malignant. Dermoscopy aids in this decision making. Historically, dermoscopy training has been geared toward dermatologists, but there is increasing recognition of the need for dermoscopy training in primary care and podiatric medicine. Dermoscopy is particularly helpful in pink (amelanotic) growths, which can lack the traditional clinical findings of melanoma. A literature review of acral melanoma and dermoscopy was performed in PubMed. We also describe a case of amelanotic acral melanoma in a 58-year-old with a rapidly enlarging painful mass on her heel. The lesion was initially thought to be a pyogenic granuloma and was treated with debridement (curettage). She was ultimately seen in the dermatology clinic, and the findings under dermoscopy were worrisome for amelanotic melanoma. Biopsy confirmed the diagnosis. The cancer metastasized, and the patient died less than 2 years later.<\/jats:p>","DOI":"10.7547\/20-184","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T14:12:26Z","timestamp":1648044746000},"source":"Crossref","is-referenced-by-count":3,"title":["Dermoscopy for the Identification of Amelanotic Acral Melanoma"],"prefix":"10.3390","volume":"112","author":[{"given":"Jenna E.","family":"Koblinski","sequence":"first","affiliation":[{"name":"The University of Arizona College of Medicine\u2013Phoenix, Phoenix, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadjh T.","family":"Ahrns","sequence":"additional","affiliation":[{"name":"Maine Medical Partners Primary Care, Maine Medical Center Department of Family Medicine, Portland, ME."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Joel","family":"Morse","sequence":"additional","affiliation":[{"name":"Foxhall Podiatry Associates PC, Washington, DC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth V.","family":"Seiverling","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Maine Medical Center, Portland, ME."},{"name":"Department of Dermatology, Tufts University School of Medicine, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"B1","series-title":"Arch Dermatol","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1001\/archdermatol.2008.609","article-title":"Acral lentiginous melanoma: incidence and survival patterns in the United States, 1986-2005","volume":"145","author":"Bradford PT","year":"2009","unstructured":"Bradford PT, Goldstein AM, McMaster ML, : Acral lentiginous melanoma: incidence and survival patterns in the United States, 1986-2005. Arch Dermatol 145: 427, 2009.1938066410.1001\/archdermatol.2008.609"},{"key":"B2","series-title":"Br J Dermatol","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1111\/j.1365-2133.2009.09594.x","article-title":"Dermoscopic features of acral lentiginous melanoma in a large series of 110 cases in a white population","volume":"162","author":"Phan A","year":"2010","unstructured":"Phan A, Dalle S, Touzet S, : Dermoscopic features of acral lentiginous melanoma in a large series of 110 cases in a white population. Br J Dermatol 162: 765, 2010.http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000275767500009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1111\/j.1365-2133.2009.09594.x31921490"},{"key":"B3","series-title":"J Am Acad Dermatol","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1067\/mjd.2003.63","article-title":"Acral lentiginous melanoma mimicking benign disease: the Emory experience","volume":"48","author":"Soon SL","year":"2003","unstructured":"Soon SL, Solomon AR Jr, Papadopoulos D, : Acral lentiginous melanoma mimicking benign disease: the Emory experience. J Am Acad Dermatol 48: 183, 2003.1258238610.1067\/mjd.2003.63"},{"key":"B4","series-title":"Br J Dermatol","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/bjd.15600","article-title":"Prognostic factors and survival in acral lentiginous melanoma","volume":"177","author":"Asgari MM","year":"2017","unstructured":"Asgari MM, Shen L, Sokil MM, : Prognostic factors and survival in acral lentiginous melanoma. Br J Dermatol 177: 428, 2017.http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000407994100029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1111\/bjd.1560028432682"},{"key":"B5","series-title":"J Am Acad Dermatol","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.jaad.2019.11.021","article-title":"Treatments and associated outcomes of acral lentiginous melanoma: a review","volume":"83","author":"Lobl MB","year":"2020","unstructured":"Lobl MB, Santos C, Clarey D, : Treatments and associated outcomes of acral lentiginous melanoma: a review. J Am Acad Dermatol 83: 230, 2020.3173896110.1016\/j.jaad.2019.11.021http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000540826700084&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3"},{"key":"B6","series-title":"Clin Dermatol","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.clindermatol.2008.09.014","article-title":"Melanoma of the feet: misdiagnosed and misunderstood","volume":"27","author":"Albreski D","year":"2009","unstructured":"Albreski D, Sloan SB: Melanoma of the feet: misdiagnosed and misunderstood. Clin Dermatol 27: 556, 2009.10.1016\/j.clindermatol.2008.09.01419880043http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271914700005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3"},{"key":"B7","series-title":"Int Wound J","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1111\/iwj.12481","article-title":"Acral melanoma with satellitosis, disguised as a longstanding diabetic ulcer: a great mimicry","volume":"13","author":"Mansur AT","year":"2016","unstructured":"Mansur AT, Demirci GT, Ozel O, : Acral melanoma with satellitosis, disguised as a longstanding diabetic ulcer: a great mimicry. Int Wound J 13: 1006, 2016.http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000387667600003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1111\/iwj.1248126400657"},{"key":"B8","series-title":"JAPMA","doi-asserted-by":"publisher","first-page":"166","DOI":"10.7547\/17-038","article-title":"The misdiagnosis of acral lentiginous melanoma: three case presentations","volume":"109","author":"Markinson BC","year":"2019","unstructured":"Markinson BC, Stowers JM, Black A, : The misdiagnosis of acral lentiginous melanoma: three case presentations. JAPMA 109: 166, 2019.10.7547\/17-038"},{"key":"B9","series-title":"JAPMA","doi-asserted-by":"publisher","first-page":"189","DOI":"10.7547\/0003-0538-105.2.189","article-title":"Acral lentiginous melanoma of the foot misdiagnosed as a traumatic ulcer: a cautionary case","volume":"105","author":"Gumaste P","year":"2015","unstructured":"Gumaste P, Penn L, Cohen N, : Acral lentiginous melanoma of the foot misdiagnosed as a traumatic ulcer: a cautionary case. JAPMA 105: 189, 2015.10.7547\/0003-0538-105.2.189"},{"key":"B10","series-title":"Melanoma Manag","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2217\/mmt.14.32","article-title":"Dermoscopy: not just for dermatologists","volume":"2","author":"Wu X","year":"2015","unstructured":"Wu X, Marchetti MA, Marghoob AA: Dermoscopy: not just for dermatologists. Melanoma Manag 2: 63, 2015.10.2217\/mmt.14.3230190832"},{"key":"B11","series-title":"Br J Dermatol","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/bjd.13861","article-title":"Pigmented nodular melanoma: the predictive value of dermoscopic features using multivariate analysis","volume":"173","author":"Pizzichetta MA","year":"2015","unstructured":"Pizzichetta MA, Kittler H, Stanganelli I, : Pigmented nodular melanoma: the predictive value of dermoscopic features using multivariate analysis. Br J Dermatol 173: 106, 2015.http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000358318700024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1111\/bjd.1386125916655"},{"key":"B12","series-title":"J Am Board Fam Med","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3122\/jabfm.2019.01.180049","article-title":"Teaching benign skin lesions as a strategy to improve the triage amalgamated dermoscopic algorithm (TADA)","volume":"32","author":"Seiverling EV","year":"2019","unstructured":"Seiverling EV, Ahrns HT, Greene A, : Teaching benign skin lesions as a strategy to improve the triage amalgamated dermoscopic algorithm (TADA). J Am Board Fam Med 32: 96, 2019.30610147http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000457274800015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.3122\/jabfm.2019.01.180049"},{"key":"B13","series-title":"JAMA Dermatol","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1001\/jamadermatol.2018.5926","article-title":"Clinical and histopathologic characteristics of melanocytic lesions on the volar skin without typical dermoscopic patterns","volume":"155","author":"Mikoshiba Y","year":"2019","unstructured":"Mikoshiba Y, Minagawa A, Koga H, : Clinical and histopathologic characteristics of melanocytic lesions on the volar skin without typical dermoscopic patterns. JAMA Dermatol 155: 578, 2019.10.1001\/jamadermatol.2018.592630865233http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467501100010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3"},{"key":"B14","series-title":"Arch Dermatol","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1001\/archderm.140.12.1485","article-title":"Vascular structures in skin tumors: a dermoscopy study","volume":"140","author":"Argenziano G","year":"2004","unstructured":"Argenziano G, Zalaudek I, Corona R, : Vascular structures in skin tumors: a dermoscopy study. Arch Dermatol 140: 1485, 2004.10.1001\/archderm.140.12.148515611426"},{"key":"B15","series-title":"Am Fam Physician","first-page":"223","article-title":"Teenager with a bleeding, red papule","volume":"93","author":"Seiverling EV","year":"2016","unstructured":"Seiverling EV, McLaughlin D, Kelifa O: Teenager with a bleeding, red papule. Am Fam Physician 93: 223, 2016.26926615"},{"key":"B16","series-title":"J Am Acad Dermatol","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.jaad.2017.11.021","article-title":"The diagnostic value and histologic correlate of distinct patterns of shiny white streaks for the diagnosis of melanoma: a retrospective, case-control study","volume":"78","author":"Verzi AE","year":"2018","unstructured":"Verzi AE, Quan VL, Walton KE, : The diagnostic value and histologic correlate of distinct patterns of shiny white streaks for the diagnosis of melanoma: a retrospective, case-control study. J Am Acad Dermatol 78: 913, 2018.10.1016\/j.jaad.2017.11.021http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000430421900026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3"},{"key":"B17","series-title":"Br J Dermatol","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1111\/j.1365-2133.2006.07193.x","article-title":"Dermoscopic findings in pyogenic granuloma","volume":"154","author":"Zaballos P","year":"2006","unstructured":"Zaballos P, Llambrich A, Cu\u00e9llar F, : Dermoscopic findings in pyogenic granuloma. Br J Dermatol 154: 1108, 2006.1670464110.1111\/j.1365-2133.2006.07193.x"},{"key":"B18","series-title":"Dermatol Pract Concept","first-page":"e2020003","article-title":"Update on dermoscopy and infectious skin diseases","volume":"10","author":"Piccolo V","year":"2020","unstructured":"Piccolo V: Update on dermoscopy and infectious skin diseases. Dermatol Pract Concept 10: e2020003, 2020.31921490http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000580873100002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3"},{"key":"B19","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"239S","DOI":"10.1097\/01.prs.0000222891.74489.33","article-title":"Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial","volume":"117f","author":"Sheehan P","year":"2006","unstructured":"Sheehan P, Jones P, Giurini JM, : Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial. Plast Reconstr Surg 117f(suppl): 239S, 2006.10.1097\/01.prs.0000222891.74489.33"},{"key":"B20","series-title":"J Am Acad Dermatol","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jaad.2018.08.055","article-title":"Guidelines of care for the management of primary cutaneous melanoma","volume":"80","author":"Swetter SM","year":"2019","unstructured":"Swetter SM, Tsao H, Bichakjian CK, : Guidelines of care for the management of primary cutaneous melanoma. J Am Acad Dermatol 80: 208, 2019.10.1016\/j.jaad.2018.08.05530392755"},{"key":"B21","series-title":"J Fam Pract","first-page":"270","article-title":"Biopsies for skin cancer detection: dispelling the myths","volume":"67","author":"Seiverling EV","year":"2018","unstructured":"Seiverling EV, Ahrns HT, Bacik LC, : Biopsies for skin cancer detection: dispelling the myths. J Fam Pract 67: 270, 2018.29726852"}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/112\/1\/20-184.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/112\/1\/20-184.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/112\/1\/20-184.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:18:37Z","timestamp":1783505917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/112\/1\/20184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":21,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.7547\/20-184","relation":{},"ISSN":["8750-7315"],"issn-type":[{"value":"8750-7315","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}