{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:50Z","timestamp":1783509290668,"version":"3.55.0"},"reference-count":23,"publisher":"MDPI AG","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Vaporous hyperoxia therapy (VHT), a patented US Food and Drug Administration 510 (k)\u2013cleared technology, is an adjunct therapy used in conjunction with standard wound care (SWC). Vaporous hyperoxia therapy is said to improve the health of wounded tissue by administering a low-frequency, noncontact, nonthermal, ionic, antimicrobial hydrating mist alternating with concentrated topical oxygen therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Vaporous hyperoxia therapy was used to treat 36 subjects with chronic diabetic foot ulcers (DFUs) that were previously treated unsuccessfully with SWC. The average age of DFUs in the study was 11 months and the average size was over 3 cm\n                    <jats:sup>2<\/jats:sup>\n                    . Wounds were Wagner grade 2 or 3 and most commonly on the plantar surface around the midfoot. Treatment consisted of twice-weekly applications of VHT and wound debridement. Subjects were followed to wound closure, 20 weeks, or 40 treatments, whichever came first.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The combination of SWC and VHT in the group that met and maintained compliance throughout the study period achieved an 83% DFU closure rate within a 20-week period. The average time for DFU closure in this study was 9.4 weeks.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Historical analysis of SWC shows a 30.9% healing rate of all wounds, not differentiating chronic wounds. Accordingly, SWC\/VHT increases chronic diabetic foot ulcer healing rates by 2.85 times compared with SWC alone. The purpose of this study was two-fold: first, to observe the effect of VHT on healing rates and time to healing in previously nonhealing DFUs; and second, to compare VHT with SWC, topical oxygen therapy, hyperbaric oxygen therapy, and ultrasound therapy.\n                  <\/jats:p>","DOI":"10.7547\/20-259","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T08:50:16Z","timestamp":1630572616000},"source":"Crossref","is-referenced-by-count":3,"title":["Treatment of Nonhealing Diabetic Foot Wounds with Vaporous Hyperoxia Therapy in Conjunction with Standard Wound Care"],"prefix":"10.3390","volume":"113","author":[{"given":"Dustin","family":"Kruse","sequence":"first","affiliation":[{"name":"Highlands-Presbyterian\/St. Luke\u2019s Podiatric Medicine and Surgery Residency Program, Denver, CO."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Morgan","sequence":"additional","affiliation":[{"name":"Highlands-Presbyterian\/St. Luke\u2019s Podiatric Medicine and Surgery Residency Program, Denver, CO."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Christensen","sequence":"additional","affiliation":[{"name":"Highlands-Presbyterian\/St. Luke\u2019s Podiatric Medicine and Surgery Residency Program, Denver, CO."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S.","family":"Derner","sequence":"additional","affiliation":[{"name":"Highlands-Presbyterian\/St. Luke\u2019s Podiatric Medicine and Surgery Residency Program, Denver, CO."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Sachs","sequence":"additional","affiliation":[{"name":"Highlands-Presbyterian\/St. Luke\u2019s Podiatric Medicine and Surgery Residency Program, Denver, CO."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"B1","series-title":"Diabetes Care","first-page":"651","article-title":"Burden of DFUs for Medicare and private insurers","volume":"37","author":"Rice JB","year":"2014","unstructured":"Rice JB, Desai U, Cummings AK, : Burden of DFUs for Medicare and private insurers. Diabetes Care 37: 651, 2014.24186882"},{"key":"B2","series-title":"Diabetes Care","first-page":"1033","article-title":"Economic costs of diabetes in the U.S. in 2012","volume":"36","year":"2013","unstructured":"American Diabetes Association: Economic costs of diabetes in the U.S. in 2012. Diabetes Care 36: 1033, 2013.23468086"},{"key":"B3","series-title":"Natl Vital Stat Rep","first-page":"1","article-title":"Deaths: leading causes for 2017","volume":"68","author":"Heron M","year":"2019","unstructured":"Heron M: Deaths: leading causes for 2017. Natl Vital Stat Rep 68: 1, 2019.32501203"},{"key":"B4","series-title":"Eur J Vasc Endovasc","first-page":"S60","article-title":"Chapter V: diabetic foot","volume":"42","author":"Lep\u00e4ntalo M","year":"2011","unstructured":"Lep\u00e4ntalo M, Apelqvist J, Setacci C, : Chapter V: diabetic foot. Eur J Vasc Endovasc 42\u2009(suppl): S60, 2011."},{"key":"B5","article-title":"Statistics about diabetes","unstructured":"American Diabetes Association: Statistics about diabetes. Available at: https:\/\/www.diabetes.org\/resources\/statistics\/statistics-about-diabetes. Accessed January 10, 2020."},{"key":"B6","series-title":"Diabetes Care","first-page":"692","article-title":"Healing of diabetic neuropathic foot ulcers receiving standard treatment. A meta-analysis","volume":"22","author":"Margolis DJ","year":"1999","unstructured":"Margolis DJ, Kantor J, Berlin JA Healing of diabetic neuropathic foot ulcers receiving standard treatment. A meta-analysis. Diabetes Care 22: 692, 1999.10332667"},{"key":"B7","series-title":"J Foot Ankle Surg","first-page":"515","article-title":"Effect of hyperbaric oxygen therapy on healing of diabetic foot ulcers","volume":"47","author":"Duzgun AP","year":"2008","unstructured":"Duzgun AP, Sat\u0131r HZ, Ozozan O, : Effect of hyperbaric oxygen therapy on healing of diabetic foot ulcers. J Foot Ankle Surg 47: 515, 2008.19239860"},{"key":"B8","series-title":"Diabetes Care","first-page":"112","article-title":"Hyperbaric oxygen therapy in the treatment of ischemic lower-extremity ulcers in patients with diabetes: results of the DAMO2CLES Multicenter Randomized Clinical Trial","volume":"41","author":"Santema KTB","year":"2017","unstructured":"Santema KTB, Stoekenbroek RM, Koelemay MJW, : Hyperbaric oxygen therapy in the treatment of ischemic lower-extremity ulcers in patients with diabetes: results of the DAMO2CLES Multicenter Randomized Clinical Trial. Diabetes Care 41: 112, 2017.29074815"},{"key":"B9","series-title":"Diabetes Care","first-page":"998","article-title":"Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes","volume":"33","author":"L\u00f6ndahl M","year":"2010","unstructured":"L\u00f6ndahl M, Katzman P, Nilsson A, : Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes. Diabetes Care 33: 998, 2010.20427683"},{"key":"B10","series-title":"Diabetes Care","first-page":"631","article-title":"Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trial","volume":"31","author":"Blume PA","year":"2008","unstructured":"Blume PA, Walters J, Payne W, : Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trial. Diabetes Care 31: 631, 2008.18162494"},{"key":"B11","series-title":"Clin Exp Pharmacol Physiol","first-page":"957","article-title":"Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds","volume":"35","author":"Gordillo GM","year":"2008","unstructured":"Gordillo GM, Roy S, Khanna S, : Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds. Clin Exp Pharmacol Physiol 35: 957, 2008.18430064"},{"key":"B12","series-title":"Mutat Res","first-page":"172","article-title":"Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen","volume":"579","author":"Fries RB","year":"2005","unstructured":"Fries RB, Wallace WA, Roy S, . Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen. Mutat Res 579: 172, 2005.16105672"},{"key":"B13","series-title":"Diabetes Care","first-page":"616","article-title":"A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical topical wound oxygen therapy (TWO2) in the treatment of chronic diabetic foot ulcers: the TWO2 study","volume":"43","author":"Frykberg RG","year":"2020","unstructured":"Frykberg RG, Franks PJ, Edmonds M, : A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical topical wound oxygen therapy (TWO2) in the treatment of chronic diabetic foot ulcers: the TWO2 study. Diabetes Care 43: 616, 2020.31619393"},{"key":"B14","series-title":"Adv Wound Care (New Rochelle)","first-page":"143","article-title":"A retrospective chart review of chronic wound patients treated with topical oxygen therapy","volume":"6","author":"Copeland K","year":"2917","unstructured":"Copeland K, Purvis AR: A retrospective chart review of chronic wound patients treated with topical oxygen therapy. Adv Wound Care (New Rochelle) 6: 143, 2917."},{"key":"B15","series-title":"S Afr Med J","first-page":"840","article-title":"Oxygen therapy and wound healing\u2014topical oxygen is not hyperbaric oxygen therapy","volume":"9","author":"Cronj\u00e9 FJ","year":"2005","unstructured":"Cronj\u00e9 FJ: Oxygen therapy and wound healing\u2014topical oxygen is not hyperbaric oxygen therapy. S Afr Med J 9: 840, 2005."},{"key":"B16","series-title":"J Am Coll Clin Wound Spec","first-page":"61","article-title":"Topical oxygen for chronic wounds: a PRO\/CON debate","volume":"5","author":"Mutluoglu M","year":"2013","unstructured":"Mutluoglu M, Cakkalkurt A, Uzun G, : Topical oxygen for chronic wounds: a PRO\/CON debate. J Am Coll Clin Wound Spec 5: 61, 2013.26199891"},{"key":"B17","series-title":"Ostomy Wound Manage","first-page":"57","article-title":"Low-frequency, noncontact, nonthermal ultrasound therapy: a review of the literature","volume":"54","author":"Unger PG","year":"2008","unstructured":"Unger PG: Low-frequency, noncontact, nonthermal ultrasound therapy: a review of the literature. Ostomy Wound Manage 54: 57, 2008."},{"key":"B18","series-title":"Wound Repair Regen","first-page":"475","article-title":"Noncontact low-frequency ultrasound therapy in the treatment of chronic wounds: a meta-analysis","volume":"19","author":"Driver VR","year":"2011","unstructured":"Driver VR, Yao M, Miller CJ: Noncontact low-frequency ultrasound therapy in the treatment of chronic wounds: a meta-analysis. Wound Repair Regen 19: 475, 2011.21649783"},{"key":"B19","series-title":"J Surg Res","first-page":"365","article-title":"Transcutaneous oxygen (TcPO2) estimates probability of healing in the ischemic extremity","volume":"60","author":"Padberg FT","year":"1996","unstructured":"Padberg FT, Black TL, Thompson PN, . Transcutaneous oxygen (TcPO2) estimates probability of healing in the ischemic extremity. J Surg Res 60: 365, 1996.8598670"},{"key":"B20","series-title":"Adv Skin Wound Care","first-page":"437","article-title":"Evaluation of clinical effectiveness of MIST ultrasound therapy for the healing of chronic wounds","volume":"19","author":"Ennis WJ","year":"2006","unstructured":"Ennis WJ, Valdes W, Gainer M, : Evaluation of clinical effectiveness of MIST ultrasound therapy for the healing of chronic wounds. Adv Skin Wound Care 19: 437, 2006.17008814"},{"key":"B21","series-title":"Ostomy Wound Manage","first-page":"24","article-title":"Ultrasound therapy for recalcitrant diabetic foot ulcers: results of a randomized, double-blind, controlled, multicenter study","volume":"51","author":"Ennis WJ","year":"2005","unstructured":"Ennis WJ, Foremann P, Mozen N, : Ultrasound therapy for recalcitrant diabetic foot ulcers: results of a randomized, double-blind, controlled, multicenter study. Ostomy Wound Manage 51: 24, 2005.16234574"},{"key":"B22","series-title":"J Diabetes Sci Technol","first-page":"883","article-title":"A prospective, randomized, double-blind multicenter study comparing continuous diffusion of oxygen therapy to sham therapy in the treatment of diabetic foot ulcers","volume":"11","author":"Niederauer MQ","year":"2017","unstructured":"Niederauer MQ, Michalek JE, Armstrong DG. A prospective, randomized, double-blind multicenter study comparing continuous diffusion of oxygen therapy to sham therapy in the treatment of diabetic foot ulcers. J Diabetes Sci Technol 11: 883, 2017.28654304"},{"key":"B23","series-title":"J Clin Invest","first-page":"1219","article-title":"Cellular and molecular basis of wound healing in diabetes","volume":"117","author":"Brem H","year":"2007","unstructured":"Brem H, Tomic-Canic M: Cellular and molecular basis of wound healing in diabetes. J Clin Invest 117: 1219, 2007.17476353"}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/113\/2\/20-259.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/japma\/article-pdf\/doi\/10.7547\/20-259\/2895073\/20-259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/113\/2\/20-259.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/113\/2\/20-259.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:19:08Z","timestamp":1783505948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/113\/2\/20259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":23,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.7547\/20-259","relation":{},"ISSN":["8750-7315"],"issn-type":[{"value":"8750-7315","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}