{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:58Z","timestamp":1783509298605,"version":"3.55.0"},"reference-count":17,"publisher":"MDPI AG","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Squamous cell carcinoma is a malignant tumor that is most commonly found on the head and neck. The current global incidence of squamous cell carcinoma at any site is estimated to be more than 1 million cases per year, with a reported 3-year mortality rate of 30%. Recurrence of squamous cell carcinoma at any site is estimated to be 15% to 50% and has been associated with greater rates of infiltration, perineural invasion, and mortality. Recent studies have shown lower-extremity squamous cell carcinoma to be distinct from squamous cell carcinoma at any site with histologic and clinical differences. Lower-extremity squamous cell carcinoma is suggestively less aggressive and carries less risk of metastasis. However, lower-extremity squamous cell carcinoma prevalence, mortality, and recurrence rates have not been extensively studied. The present report depicts a case of recurrent squamous cell carcinoma originating in 2006 in the dorsal forefoot and provides the clinical management of subsequent recurrence episodes, with excisions from 2015 and 2020.<\/jats:p>","DOI":"10.7547\/21-044a","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T11:24:44Z","timestamp":1725535484000},"source":"Crossref","is-referenced-by-count":0,"title":["An Aggressively Recurrent Squamous Cell Carcinoma of the Foot"],"prefix":"10.3390","volume":"114","author":[{"given":"Arthur","family":"Tarricone","sequence":"first","affiliation":[{"name":"State University of New York Downstate, Brooklyn, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Gee","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at the Mount Sinai Hospital, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla De La","family":"Mata","sequence":"additional","affiliation":[{"name":"Lenox Hill Hospital at Northwell Health, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Axman","sequence":"additional","affiliation":[{"name":"NYC Health and Hospitals\/Queens Hospital Center, Queens, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Buricea","sequence":"additional","affiliation":[{"name":"NYC Health and Hospitals\/Queens Hospital Center, Queens, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Trepal","sequence":"additional","affiliation":[{"name":"State University of New York Downstate, Brooklyn, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at the Mount Sinai Hospital, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"B1","series-title":"J Clin Invest","first-page":"464","article-title":"From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma","volume":"122","author":"Ratushny V","year":"2012","unstructured":"Ratushny V, Gober MD, Hick R, et al: From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. 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