{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:34Z","timestamp":1783509274466,"version":"3.55.0"},"reference-count":31,"publisher":"MDPI AG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,26]]},"abstract":"<jats:p>Toenail onychomycosis is a common condition that is equally challenging for podiatrists and patients. This case study documents a 26-year-old woman with bilateral total dystrophic onychomycosis of at least 5 years' duration. She had previously failed to respond to treatment with ciclopirox nail lacquer 8% and despite hiding her condition with nail polish, was suffering from embarrassment, distress and low self-esteem. At initial consult, one hundred percent of both great toenails were affected. After discussion of all treatment options, the patient opted for topical efinaconazole 10% solution, once daily for 48 weeks. Significant improvement was noted at the first (4 week) assessment period. This improvement was maintained through each subsequent virtual consult and complete cure was seen at a 30-week follow-up visit. To the author's knowledge this is the first published report on the use of efinaconazole in total dystrophic onychomycosis. It suggests that the product may be effective in patients with even the most severe and treatment recalcitrant disease, who are unwilling or unable to tolerate systemic antifungal therapy.<\/jats:p>","DOI":"10.7547\/21-050","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T09:52:35Z","timestamp":1635241955000},"source":"Crossref","is-referenced-by-count":0,"title":["Total Dystrophic Onychomycosis Successfully Treated with Efinaconazole Topical Solution in Times of COVID: A Case Study"],"prefix":"10.3390","author":[{"given":"Matthew G","family":"Garoufalis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"B1","series-title":"Hosp Med","first-page":"11","article-title":"Advances in the diagnosis and treatment of onychomycosis","volume":"34","author":"Scher RK","year":"1998","unstructured":"Scher RK, Coppa LM: Advances in the diagnosis and treatment of onychomycosis. 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