{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:48Z","timestamp":1783509288366,"version":"3.55.0"},"reference-count":28,"publisher":"MDPI AG","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Malignant melanoma with osteocartilaginous differentiation is extremely rare. We report a case of periungual osteocartilaginous melanoma (OCM) on the right hallux. A 59-year-old man presented with a rapidly growing mass with drainage on his right great toe after treatment of ingrown toenail and infection 3 months earlier. Physical examination showed a 2.0\u00d71.5\u00d71.0-cm, malodorous, erythematous, dusky, granuloma-like mass along the fibular border of the right hallux. Pathologic evaluation of the excisional biopsy revealed diffuse epithelioid and chondroblastoma-like melanocytes with atypia and pleomorphism in the dermis with strong SOX10 immunostaining. The lesion was diagnosed as osteocartilaginous melanoma. The patient was referred to a surgical oncologist for further treatment. Osteocartilaginous melanoma is a rare variant of malignant melanoma that needs to be differentiated from chondroblastoma and other lesions. Immunostains for SOX10, H3K36M, and SATB2 are helpful for the differential diagnosis.<\/jats:p>","DOI":"10.7547\/21-064","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T19:49:51Z","timestamp":1678391391000},"source":"Crossref","is-referenced-by-count":0,"title":["Periungual Amelanocytic Malignant Melanoma with Osteocartilaginous Differentiation of the Right Hallux: A Case Report"],"prefix":"10.3390","volume":"113","author":[{"given":"Enzo","family":"Leone","sequence":"first","affiliation":[{"name":"Foot and Ankle Specialists of the Mid-Atlantic LLC, Rockville, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene","family":"Mirkin","sequence":"additional","affiliation":[{"name":"Foot and Ankle Specialists of the Mid-Atlantic LLC, Rockville, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingpei","family":"Hao","sequence":"additional","affiliation":[{"name":"Foot and Ankle Specialists of the Mid-Atlantic LLC, Rockville, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"B1","series-title":"Am J Dermatopathol","first-page":"331","article-title":"Unusual stromal patterns in truly recurrent and satellite metastatic lesions of malignant melanoma","volume":"6","author":"Urmacher C","year":"1984","unstructured":"Urmacher C: Unusual stromal patterns in truly recurrent and satellite metastatic lesions of malignant melanoma. 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