{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:56:32Z","timestamp":1793904992166,"version":"4.8.0"},"reference-count":45,"publisher":"MDPI AG","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Reamputations are frequent after minor amputations performed for diabetic foot osteomyelitis (DFO). Whether the type of amputation is associated with a particular outcome is unknown. The aim of this study was to evaluate whether amputations of the transarticular compared with the transosseous type have different rates of clinical and microbiological failure.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    We actively followed 284 patients with DFO (543 episodes of minor foot amputations: 203 transarticular and 340 transosseous) for 1 year. We assessed the long-term effect of transarticular compared with transosseous amputations on the rates of clinical and microbiological failure using comparative statistics, log-rank survival analyses, Kaplan-Meier curves, and multivariate Cox regressions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    In 122 episodes (22.5%) there was clinical failure that led to reamputation. The difference in the risk of clinical failure of transarticular versus transosseous amputations was nonsignificant (44 [21.7%] versus 78 [22.9%]; Pearson \u03c7\n                    <jats:sup>2<\/jats:sup>\n                    test:\n                    <jats:italic>P<\/jats:italic>\n                    = .73). Similarly, the difference in microbiological failure (32 episodes, 5.9% overall) between groups was nonsignificant (11 [5.4%] and 21 [6.2%], respectively;\n                    <jats:italic>P<\/jats:italic>\n                    = .72). The mean time between the index surgery and clinical failure was 2.2 months for transarticular and 3.2 months for transosseous amputations (Mann-Whitney\n                    <jats:italic>U<\/jats:italic>\n                    test;\n                    <jats:italic>P<\/jats:italic>\n                    = .39). Survival analyses showed similar evolutions for each group (log-rank test;\n                    <jats:italic>P<\/jats:italic>\n                    = .85). In the multivariate Cox regression analysis, the type of amputation did not significantly influence clinical or microbiological failures.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    In DFO, there is no significant difference between transarticular and transosseous amputations within 1 year in the incidence of clinical or microbiological failures.\n                  <\/jats:p>","DOI":"10.7547\/21-205","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T08:59:01Z","timestamp":1731574741000},"source":"Crossref","is-referenced-by-count":2,"title":["Transarticular versus Transosseous Amputations in Diabetic Foot Osteomyelitis: A Retrospective Comparative Study"],"prefix":"10.3390","volume":"114","author":[{"given":"Felix W.A.","family":"Waibel","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madlaina","family":"Sch\u00f6ni","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas V.","family":"H\u00e4ller","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Langthaler","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin C.","family":"Berli","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Lipsky","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle, WA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilker","family":"U\u00e7kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Jud","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"B1","series-title":"Foot Ankle Clin","first-page":"569","article-title":"Osteomyelitis of the foot and ankle: diagnosis, epidemiology, and treatment","volume":"19","author":"Lindbloom BJ","year":"2014","unstructured":"Lindbloom BJ, James ER, McGarvey WC: Osteomyelitis of the foot and ankle: diagnosis, epidemiology, and treatment. 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