{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:57Z","timestamp":1783509297269,"version":"3.55.0"},"reference-count":16,"publisher":"MDPI AG","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Calcified tissue exposed in a leg ulcer can become infected and develop into a nidus of infection leading to sepsis. This case details a patient with a leg wound secondary to skin biopsy. This leg ulceration did not heal due to an underlying calcified mass and led to five hospital admissions for sepsis. She was diagnosed as having calcinosis cutis, which was suspected to be the source of her infections. The calcified mass was resected, and she healed uneventfully without further infections. Calcified soft-tissue masses should be considered in nonhealing leg ulcers and ulcers with multiple recurrent infections. Radiographs can be used to diagnose this condition, and surgical excision can be considered in cases of infection.<\/jats:p>","DOI":"10.7547\/22-065","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T11:17:18Z","timestamp":1725535038000},"source":"Crossref","is-referenced-by-count":0,"title":["Leg Ulceration with Infected Calcinosis Cutis Mimicking Osteomyelitis: A Case Report"],"prefix":"10.3390","volume":"114","author":[{"given":"Fahad","family":"Hussain","sequence":"first","affiliation":[{"name":"Foot and Ankle Surgery, RWJBarnabas Health\u2013Community Medical Center, Toms River, NJ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzma","family":"Zafar","sequence":"additional","affiliation":[{"name":"Pathology, Cooperman Barnabas Medical Center, Livingston, NJ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin C.","family":"Lenz","sequence":"additional","affiliation":[{"name":"Ocean County Foot & Ankle Surgical Associates, Toms River, NJ."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"B1","series-title":"Pediatr Dermatol","first-page":"227","article-title":"Calcinosis cutis following trauma","volume":"22","author":"Larralde M","year":"2005","unstructured":"Larralde M, Giachetti A, C\u00e1ceres MR, et al: Calcinosis cutis following trauma. Pediatr Dermatol 22: 227, 2005."},{"key":"B2","series-title":"StatPearls [Internet]","article-title":"Calcinosis Cutis","author":"Le C","year":"2021","unstructured":"Le C, Bedocs PM: \u201cCalcinosis Cutis,\u201d in StatPearls [Internet], StatPearls Publishing, Treasure Island, FL, July 17, 2021."},{"key":"B3","series-title":"Treatment options. J Am Acad Dermatol","first-page":"15","article-title":"Calcinosis cutis: part II","volume":"65","author":"Reiter N","year":"2011","unstructured":"Reiter N, El-Shabrawi L, Leinweber B, et al: Calcinosis cutis: part II. Treatment options. J Am Acad Dermatol 65: 15, 2011."},{"key":"B4","series-title":"J Am Acad Dermatol","first-page":"424","article-title":"Treatment of calcinosis cutis by extracorporeal shock-wave lithotripsy","volume":"66","author":"Sultan-Bichat N","year":"2012","unstructured":"Sultan-Bichat N, Menard J, Perceau G, et al: Treatment of calcinosis cutis by extracorporeal shock-wave lithotripsy. J Am Acad Dermatol 66: 424, 2012."},{"key":"B5","series-title":"Arch Dermatol Res","first-page":"515","article-title":"Local, non-systemic, and minimally invasive therapies for calcinosis cutis: a systematic review","volume":"314","author":"Nowaczyk J","year":"2022","unstructured":"Nowaczyk J, Zawistowski M, Fiedor P: Local, non-systemic, and minimally invasive therapies for calcinosis cutis: a systematic review. Arch Dermatol Res 314: 515, 2022."},{"issue":"suppl 1","key":"B6","series-title":"J Am Acad Dermatol","first-page":"S263","article-title":"Treatment of cutaneous calcinosis in CREST syndrome by extracorporeal shock wave lithotripsy","volume":"53","author":"Sparsa A","year":"2005","unstructured":"Sparsa A, Lesaux N, Kessler E, et al: Treatment of cutaneous calcinosis in CREST syndrome by extracorporeal shock wave lithotripsy. J Am Acad Dermatol 53(suppl 1): S263, 2005."},{"key":"B7","series-title":"J Dermatol","first-page":"480","article-title":"A case of persistent subepidermal calcified nodule in an adult treated with CO2 laser","volume":"31","author":"Joo YH","year":"2004","unstructured":"Joo YH, Kwon IH, Huh CH, et al: A case of persistent subepidermal calcified nodule in an adult treated with CO2 laser. J Dermatol 31: 480, 2004."},{"key":"B8","series-title":"Lupus","first-page":"1630","article-title":"Calcinosis cutis universalis in a patient with systemic lupus erythematosus: a case report","volume":"29","author":"Khudadah M","year":"2020","unstructured":"Khudadah M, Jawad A, Pyne D: Calcinosis cutis universalis in a patient with systemic lupus erythematosus: a case report. Lupus 29: 1630, 2020."},{"key":"B9","series-title":"Bull Hosp Jt Dis Orthop Inst","first-page":"75","article-title":"Calcinosis circumscripta: indications for surgery","volume":"49","author":"Lipskeir E","year":"1989","unstructured":"Lipskeir E, Weizenbluth M: Calcinosis circumscripta: indications for surgery. Bull Hosp Jt Dis Orthop Inst 49: 75, 1989."},{"key":"B10","series-title":"J Foot Ankle Surg","first-page":"603","article-title":"Surgical management of idiopathic ulcerative calcinosis cutis in the lower extremity: a case report","volume":"59","author":"Johnson AR Jr","year":"2020","unstructured":"Johnson AR Jr, Mooshol D, Thakar V, et al: Surgical management of idiopathic ulcerative calcinosis cutis in the lower extremity: a case report. J Foot Ankle Surg 59: 603, 2020."},{"key":"B11","series-title":"Dermatol Surg","first-page":"575","article-title":"Calcinosis cutis of juvenile dermatomyositis treated with incision and drainage","volume":"34","author":"Wu JJ","year":"2008","unstructured":"Wu JJ, Metz BJ: Calcinosis cutis of juvenile dermatomyositis treated with incision and drainage. Dermatol Surg 34: 575, 2008."},{"key":"B12","series-title":"J Hand Surg Br","first-page":"638","article-title":"Extensive subcutaneous calcification of the forearm in systemic lupus erythematosus","volume":"19","author":"Minami A","year":"1994","unstructured":"Minami A, Suda K, Kaneda K, et al: Extensive subcutaneous calcification of the forearm in systemic lupus erythematosus. J Hand Surg Br 19: 638, 1994."},{"key":"B13","series-title":"Arthritis Rheum","first-page":"570","article-title":"Surgical management of calcinosis cutis universalis in systemic lupus erythematosus","volume":"40","author":"Cousins MA","year":"1997","unstructured":"Cousins MA, Jones DB, Whyte MP, et al: Surgical management of calcinosis cutis universalis in systemic lupus erythematosus. Arthritis Rheum 40: 570, 1997."},{"key":"B14","series-title":"Rheumatol Clin","first-page":"187","article-title":"Superinfected calcinosis cutis as a presentation of a limited form systemic sclerosis","volume":"10","author":"Bernardo Cofi\u00f1o J","year":"2014","unstructured":"Bernardo Cofi\u00f1o J, Trapiella Mart\u00ednez L: Superinfected calcinosis cutis as a presentation of a limited form systemic sclerosis. Rheumatol Clin 10: 187, 2014."},{"key":"B15","series-title":"Br J Dermatol","first-page":"1073","article-title":"Plain radiography is effective for the detection of calcinosis cutis occurring in association with autoimmune connective tissue disease","volume":"170","author":"Shahi V","year":"2014","unstructured":"Shahi V, Wetter DA, Howe BM, et al: Plain radiography is effective for the detection of calcinosis cutis occurring in association with autoimmune connective tissue disease. Br J Dermatol 170: 1073, 2014."},{"key":"B16","series-title":"StatPearls [Internet]","article-title":"Osteoma Cutis","author":"Limaiem F","year":"2021","unstructured":"Limaiem F, Sergent SR: \u201cOsteoma Cutis,\u201d in StatPearls [Internet], StatPearls Publishing, Treasure Island, FL, July 22, 2021."}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/114\/4\/22-065.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/114\/4\/22-065.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/114\/4\/22-065.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:19:45Z","timestamp":1783505985000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/114\/4\/22065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":16,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.7547\/22-065","relation":{},"ISSN":["8750-7315"],"issn-type":[{"value":"8750-7315","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]}}}