{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:49Z","timestamp":1783509289010,"version":"3.55.0"},"reference-count":14,"publisher":"MDPI AG","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>\n                    Necrotizing fasciitis is a devastating inflammatory infection requiring emergent medical treatment and surgical intervention. Even with timely management, the mortality rate of necrotizing fasciitis approaches 25%. The causative bacteria invade fascial planes and express toxins that advance rapidly. Here, we document a rare case of necrotizing fasciitis from\n                    <jats:italic>Serratia marcescens<\/jats:italic>\n                    infection.\n                    <jats:italic>Serratia marcescens<\/jats:italic>\n                    is capable of inducing a necrotizing inflammatory cascade mediated by extracellular cytotoxin and lipase. In this case report, a 90-year-old man presented to our emergency department from a long-term care facility with a relatively benign-appearing ulcer with surrounding cellulitis on the right ankle. Blood cultures and wound cultures confirmed the organism to be\n                    <jats:italic>S marcescens<\/jats:italic>\n                    . A multidisciplinary team was consulted for management. The patient received antibiotic therapy and medical support, but because of his comorbid conditions and social situation, the designated medical decision maker opted for comfort care rather than aggressive surgical debridement. The patient progressed through the clinical stages of necrotizing fasciitis. Within 36 hours, the patient died as result of sepsis-induced organ failure.\n                  <\/jats:p>","DOI":"10.7547\/22-113","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T13:46:20Z","timestamp":1689601580000},"source":"Crossref","is-referenced-by-count":3,"title":["Serratia marcescens Necrotizing Fasciitis of the Ankle: A Case Report"],"prefix":"10.3390","volume":"113","author":[{"given":"Ramez","family":"Sakkab","sequence":"first","affiliation":[{"name":"Scripps Mercy Hospital, San Diego, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"MacRae","sequence":"additional","affiliation":[{"name":"Scripps Mercy Hospital, San Diego, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quynh Giao","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Scripps Mercy Hospital, San Diego, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Ballon-Landa","sequence":"additional","affiliation":[{"name":"Scripps Mercy Hospital, San Diego, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"B1","series-title":"J Emerg Med","first-page":"261","article-title":"Modern concepts of the diagnosis and treatment of necrotizing fasciitis","volume":"39","author":"Edlich RF","year":"2010","unstructured":"Edlich RF, Cross CL, Dahlstrom JJ, : Modern concepts of the diagnosis and treatment of necrotizing fasciitis. J Emerg Med 39: 261, 2010."},{"key":"B2","series-title":"J Trauma Acute Care","first-page":"560","article-title":"Necrotizing fasciitis: classification, diagnosis, and management","volume":"72","author":"Lancerotto L","year":"2012","unstructured":"Lancerotto L, Tocco I, Salmaso R, : Necrotizing fasciitis: classification, diagnosis, and management. J Trauma Acute Care 72: 560, 2012."},{"key":"B3","series-title":"World J Emerg Surg","first-page":"1","article-title":"Pattern and predictors of mortality in necrotizing fasciitis patients in a single tertiary hospital","volume":"11","author":"Jabbour G","year":"2016","unstructured":"Jabbour G, El-Menyar A, Peralta R, : Pattern and predictors of mortality in necrotizing fasciitis patients in a single tertiary hospital. World J Emerg Surg 11: 1, 2016."},{"key":"B4","series-title":"Infection","first-page":"371","article-title":"Necrotizing fasciitis due to Serratia marcescens: case report and review of the literature","volume":"44","author":"Majumdar R","year":"2016","unstructured":"Majumdar R, Crum-Cianflone NF: Necrotizing fasciitis due to Serratia marcescens: case report and review of the literature. Infection 44: 371, 2016."},{"key":"B5","series-title":"JAPMA","first-page":"231","article-title":"Lower-extremity infections caused by Serratia marcescens: a report of three cases and a literature review","volume":"107","author":"Marin L","year":"2017","unstructured":"Marin L, Rowan R, Mantilla A, : Lower-extremity infections caused by Serratia marcescens: a report of three cases and a literature review. JAPMA 107: 231, 2017."},{"key":"B6","series-title":"Int J Dermatol","first-page":"1036","article-title":"Staging of necrotizing fasciitis based on the evolving cutaneous features","volume":"46","author":"Wang YS","year":"2007","unstructured":"Wang YS, Wong CH, Tay YK: Staging of necrotizing fasciitis based on the evolving cutaneous features. Int J Dermatol 46: 1036, 2007."},{"key":"B7","series-title":"Eur J Dermatol","first-page":"373","article-title":"Skin ulcers caused by Serratia marcescens: three cases and a review of the literature","volume":"26","author":"Veraldi S","year":"2016","unstructured":"Veraldi S, Nazzaro G: Skin ulcers caused by Serratia marcescens: three cases and a review of the literature. Eur J Dermatol 26: 373, 2016."},{"key":"B8","series-title":"J Clin Aesthet Dermatol","first-page":"55","article-title":"A case of subacute necrotizing fasciitis due to Serratia marcescens","volume":"14","author":"Roberts M","year":"2021","unstructured":"Roberts M, Crasto D, Roy D: A case of subacute necrotizing fasciitis due to Serratia marcescens. J Clin Aesthet Dermatol 14: 55, 2021."},{"key":"B9","series-title":"Indian J Pediatr","first-page":"414","article-title":"Necrotizing fasciitis due to Serratia marcescens infection following snake bite","volume":"89","author":"Chidambaram M","year":"2022","unstructured":"Chidambaram M, Charan MS, Saraga K, : Necrotizing fasciitis due to Serratia marcescens infection following snake bite. Indian J Pediatr 89: 414, 2022."},{"key":"B10","series-title":"JAPMA","first-page":"144","article-title":"Necrotizing fasciitis of the lower extremity caused by Serratia marcescens: a case report","volume":"106","author":"Heigh EG","year":"2016","unstructured":"Heigh EG, Maletta-Bailey A, Haight J, : Necrotizing fasciitis of the lower extremity caused by Serratia marcescens: a case report. JAPMA 106: 144, 2016."},{"key":"B11","series-title":"J Infect Chemother","first-page":"335","article-title":"Necrotizing soft tissue infection caused by Serratia marcescens: a case report and literature review","volume":"22","author":"Hagiya H","year":"2016","unstructured":"Hagiya H, Ojima M, Yoshida T, : Necrotizing soft tissue infection caused by Serratia marcescens: a case report and literature review. J Infect Chemother 22: 335, 2016."},{"key":"B12","series-title":"J Plast Reconstr Aesthet Surg","first-page":"1712","article-title":"Raised serum lactate: a marker of necrotizing fasciitis?","volume":"66","author":"Murphy G","year":"2013","unstructured":"Murphy G, Markeson D, Choa R, : Raised serum lactate: a marker of necrotizing fasciitis? J Plast Reconstr Aesthet Surg 66: 1712, 2013."},{"key":"B13","series-title":"J Orthop Surg Res","first-page":"73","article-title":"Lactate on emergency department arrival as a predictor of in-hospital mortality in necrotizing fasciitis: a retrospective study","volume":"14","author":"Chang CP","year":"2019","unstructured":"Chang CP, Fann WC, Wu SR, : Lactate on emergency department arrival as a predictor of in-hospital mortality in necrotizing fasciitis: a retrospective study. J Orthop Surg Res 14: 73, 2019."},{"key":"B14","series-title":"N Engl J Med","first-page":"1689","article-title":"Early recognition of potentially fatal necrotizing fasciitis: the use of frozen-section biopsy","volume":"310","author":"Stamenkovic I","year":"1984","unstructured":"Stamenkovic I, Lew PD: Early recognition of potentially fatal necrotizing fasciitis: the use of frozen-section biopsy. N Engl J Med 310: 1689, 1984."}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/113\/3\/22-113.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/113\/3\/22-113.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/113\/3\/22-113.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:19:15Z","timestamp":1783505955000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/113\/3\/22113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":14,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.7547\/22-113","relation":{},"ISSN":["8750-7315"],"issn-type":[{"value":"8750-7315","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]}}}