{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:15:23Z","timestamp":1783509323661,"version":"3.55.0"},"reference-count":57,"publisher":"MDPI AG","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Dermatophytoma, also described as a longitudinal streak\/spike, is a form of onychomycosis that presents as yellow\/white streaks or patches in the subungual space, with dense fungal masses encased in biofilm. This scoping review of the literature was conducted to address a general lack of information about the epidemiology, pathophysiology, and treatment of dermatophytomas in onychomycosis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A search was performed in the PubMed and Embase databases for the terms \u201clongitudinal spike\u201d or \u201cdermatophytoma.\u201d Outcomes of interest were definition, prevalence, methods used for diagnosis, treatments, and treatment efficacy. Inclusion and exclusion of search results required agreement between two independent reviewers.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Of a total of 51 records, 37 were included. Two reports provided the first unique definitions\/clinical features of dermatophytomas. Overall, many descriptions were found, but one conclusive definition was lacking. Prevalence data were limited and inconsistent. The most frequently mentioned diagnostic techniques were clinical assessment, potassium hydroxide\/microscopy, and fungal culture\/mycology. Oral terbinafine and topical efinaconazole 10% were the most frequently mentioned treatments, followed by topical luliconazole 5% and other oral treatments (itraconazole, fluconazole, fosravuconazole). In studies with five or more patients without nail excision, cure rates were highest with efinaconazole 10%, which ranged from 41% to 100% depending on the clinical and\/or mycologic assessment evaluated. Other drugs with greater than or equal to 50% cure rates were topical luliconazole 5% (50%), oral fosravuconazole (57%), and oral terbinafine (67%). In studies that combined oral terbinafine treatment with nail excision using surgical or chemical (40% urea) methods, cure rates ranged from 50% to 100%.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    There is little published information regarding dermatophytomas in onychomycosis. More clinical research and physician education are needed. Although dermatophytomas have historically been considered difficult to treat, the efficacy data gathered in this scoping review have demonstrated that newer topical treatments are effective, as are oral antifungals in combination with chemical or surgical methods.\n                  <\/jats:p>","DOI":"10.7547\/22-161","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T12:35:14Z","timestamp":1715862914000},"source":"Crossref","is-referenced-by-count":6,"title":["Dermatophytomas in Onychomycosis: A Scoping Review of Prevalence, Diagnosis, and Treatment"],"prefix":"10.3390","volume":"114","author":[{"given":"Shari R.","family":"Lipner","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Vlahovic","sequence":"additional","affiliation":[{"name":"Temple University School of Podiatric Medicine, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"Ghannoum","sequence":"additional","affiliation":[{"name":"Case Western Reserve University, Cleveland, OH; University Hospitals Cleveland Medical Center, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boni","family":"Elewski","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham School of Medicine, Birmingham, AL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren S.","family":"Joseph","sequence":"additional","affiliation":[{"name":"JAPMA, Rockville, MD; Arizona College of Podiatric Medicine, Midwestern University, Glendale, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"B1","series-title":"J Am Acad Dermatol","first-page":"641","article-title":"A large-scale North American study of fungal isolates from nails: the frequency of onychomycosis, fungal distribution, and antifungal susceptibility patterns","volume":"43","author":"Ghannoum MA","year":"2000","unstructured":"Ghannoum MA, Hajjeh RA, Scher R, et al: A large-scale North American study of fungal isolates from nails: the frequency of onychomycosis, fungal distribution, and antifungal susceptibility patterns. 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