{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:15:27Z","timestamp":1783509327025,"version":"3.55.0"},"reference-count":16,"publisher":"MDPI AG","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>Rheumatoid nodulosis is a rare variant of rheumatoid arthritis, characterized by similar but milder joint and systemic symptoms compared to typical rheumatoid arthritis. We report a case of rheumatoid nodulosis in a 61-year-old woman with a 6-month history of swelling and pain in her right foot, with subsequent swelling on the back of her right hand, in her left wrist, and over the right tibial tubercle. Radiography showed well-defined radiolucent lesions in several bones of the right foot and the left hand, without narrowing of joint spaces. The 18F-fluorodeoxyglucose positron emission tomography\/computed tomography (FDG PET\/CT) scan showed prominent uptake in multiple joints. Magnetic resonance imaging of the right foot showed an ill-defined hypervascular mass lesion with solid and cystic components involving the tarsal and metacarpal bones. Imaging features were suggestive of inflammatory lesions, and the biopsy specimen of the mass in the left foot showed typical histopathologic findings of rheumatoid nodule.<\/jats:p>","DOI":"10.7547\/23-051","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:37:48Z","timestamp":1761745068000},"source":"Crossref","is-referenced-by-count":0,"title":["A Case of Rheumatoid Nodulosis with Extensive Bone Erosion by a Rheumatoid Nodule in the Foot"],"prefix":"10.3390","volume":"115","author":[{"given":"Hirofumi","family":"Koike","sequence":"first","affiliation":[{"name":"Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Uetani","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamato","family":"Kurohama","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Toya","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"B1","series-title":"J Rheumatol","first-page":"427","article-title":"Rheumatoid nodulosis: report of two new cases and discussion of diagnostic criteria","volume":"15","author":"Courett M","year":"1988","unstructured":"Courett M, Combe B, Chuong VT, ET AL: Rheumatoid nodulosis: report of two new cases and discussion of diagnostic criteria. J Rheumatol 15: 427, 1988."},{"key":"B2","series-title":"Am J Med","first-page":"279","article-title":"Rheumatoid nodules: review of the spectrum of associated conditions and proposal of a new classification, with a report of four seronegative cases","volume":"76","author":"Kaye BR","year":"1984","unstructured":"Kaye BR, Kaye RL, Bobrove A: Rheumatoid nodules: review of the spectrum of associated conditions and proposal of a new classification, with a report of four seronegative cases. Am J Med 76: 279, 1984."},{"key":"B3","series-title":"Arthritis Rheum","first-page":"761","article-title":"The rheumatoid nodule","volume":"33","author":"ZIFF M","year":"1990","unstructured":"ZIFF M: The rheumatoid nodule. Arthritis Rheum 33: 761, 1990."},{"key":"B4","article-title":"Rheumatoid Arthritis. A definition of the disease and a clinical description based on a numerical study of 293 patients and controls","author":"Short CL","year":"1957","unstructured":"Short CL, Bauer W, Reynolds WE: Rheumatoid Arthritis. A definition of the disease and a clinical description based on a numerical study of 293 patients and controls. Harvard University Press: 1957."},{"key":"B5","series-title":"Dermatol Clin","first-page":"361","article-title":"Rheumatoid nodules","volume":"33","author":"Tilstra JS","year":"2015","unstructured":"Tilstra JS, Lienesch DW: Rheumatoid nodules. Dermatol Clin 33: 361, 2015."},{"key":"B6","series-title":"Ann Rheum Dis","first-page":"254","article-title":"Significance of positive tests for rheumatoid factor in the prognosis of rheumatoid arthritis. A follow-up study","volume":"29","author":"Cats A","year":"1970","unstructured":"Cats A, Hazevoet HM: Significance of positive tests for rheumatoid factor in the prognosis of rheumatoid arthritis. A follow-up study. Ann Rheum Dis 29: 254, 1970."},{"key":"B7","series-title":"Semin Cutan Medic and Surg","first-page":"100","article-title":"Rheumatoid nodule","volume":"26","author":"Garc\u00eda-Patos V","year":"2007","unstructured":"Garc\u00eda-Patos V: Rheumatoid nodule. Semin Cutan Medic and Surg 26: 100, 2007."},{"key":"B8","series-title":"Arch Intern Med","first-page":"615","article-title":"Rheumatoid nodulosis. A relatively benign rheumatoid variant","volume":"141","author":"Wisnieski JJ","year":"1981","unstructured":"Wisnieski JJ, Askari AD: Rheumatoid nodulosis. A relatively benign rheumatoid variant. Arch Intern Med 141: 615, 1981."},{"key":"B9","series-title":"Arch Dermatol","first-page":"853","article-title":"\"Rheumatoid\u201d nodules of the skin: their significance as an isolated finding","volume":"88","author":"Lowney ED","year":"1963","unstructured":"Lowney ED, Simons HM: \"Rheumatoid\u201d nodules of the skin: their significance as an isolated finding. Arch Dermatol 88: 853, 1963."},{"key":"B10","series-title":"Arch Dermatol","first-page":"156","article-title":"Pseudoxanthomatous rheumatoid nodules","volume":"95","author":"Watt TL","year":"1967","unstructured":"Watt TL, Baumann RR: Pseudoxanthomatous rheumatoid nodules. Arch Dermatol 95: 156, 1967."},{"key":"B11","series-title":"JAMA","first-page":"338","article-title":"Rheumatoid disease without joint involvement","volume":"228","author":"Ganda OP","year":"1974","unstructured":"Ganda OP, Caplan HI: Rheumatoid disease without joint involvement. JAMA 228: 338, 1974."},{"key":"B12","series-title":"JAMA","first-page":"319","article-title":"Subcutaneous rheumatoid nodules and serum rheumatoid factor without arthritis","volume":"229","author":"Askari A","year":"1974","unstructured":"Askari A, Moskowitz RW, Goldberg VM: Subcutaneous rheumatoid nodules and serum rheumatoid factor without arthritis. JAMA 229: 319, 1974."},{"key":"B13","series-title":"Arthritis Rheum","first-page":"49","article-title":"Rheumatoid nodulosis: an unusual variant of rheumatoid disease","volume":"18","author":"Ginsberg MH","year":"1975","unstructured":"Ginsberg MH, Genant HK, Y\u00fc TF, ET AL: Rheumatoid nodulosis: an unusual variant of rheumatoid disease. Arthritis Rheum 18: 49, 1975."},{"key":"B14","series-title":"Rheumatol Rep","first-page":"e4","article-title":"Large elbow nodules in a patient with rheumatoid nodulosis","volume":"2","author":"Frikha F","year":"2010","unstructured":"Frikha F, Ellouz S, Trigui M, ET AL: Large elbow nodules in a patient with rheumatoid nodulosis. Rheumatol Rep 2: e4, 2010."},{"key":"B15","series-title":"J Clin Rheumatol","first-page":"296","article-title":"Rheumatoid nodulosis: is it a different subset of rheumatoid arthritis?","volume":"9","author":"Maldonado I","year":"2003","unstructured":"Maldonado I, Eid H, Rodriguez GR, ET AL: Rheumatoid nodulosis: is it a different subset of rheumatoid arthritis? J Clin Rheumatol 9: 296, 2003."},{"issue":"5","key":"B16","series-title":"J Clin Cell Immunol","article-title":"Rheumatoid nodules predating seroconversion and rheumatoid arthritis: an uncommon case report","volume":"4","author":"Gualtierotti R","year":"2013","unstructured":"Gualtierotti R, Ingegnoli F: Rheumatoid nodules predating seroconversion and rheumatoid arthritis: an uncommon case report. J Clin Cell Immunol 4: 5, 2013."}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/115\/5\/23-051.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/115\/5\/23-051.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/115\/5\/23-051.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:20:18Z","timestamp":1783506018000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/115\/5\/23051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":16,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.7547\/23-051","relation":{},"ISSN":["8750-7315"],"issn-type":[{"value":"8750-7315","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]}}}