{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:15:25Z","timestamp":1783509325542,"version":"3.55.0"},"reference-count":12,"publisher":"MDPI AG","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Chemical matrixectomy (CM) is a common procedure to correct painful and ingrown toenails. At our institution, CMs are often performed with either sodium hydroxide (NaOH) or phenol as the chemical agent for germinal nail matrix destruction. The primary aim of this study was to evaluate the recurrence and reoperation rates for this procedure using different chemical agents.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    The medical records of 192 patients during a 2-year period were reviewed. All of the CMs were performed in a standard fashion by three podiatric physicians.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Among phenol partial nail avulsions, 46 nail border removals were performed. Among NaOH partial nail avulsions, 258 nail borders were treated. Mean follow-up was 93 days (median, 17 days). Among partial nail avulsions, the mean reoperation rate per border for CM with phenol was 6.5%. In comparison, the reoperation rate for CM with NaOH was 7.8% (\n                    <jats:italic>P<\/jats:italic>\n                    = .89), indicating that there is no statistically significant difference in reoperation rates between these two chemicals. The mean recurrence of painful nail edge rate per border for CM with phenol was 10.9%. In contrast, with NaOH this rate was 8.1% (\n                    <jats:italic>P<\/jats:italic>\n                    = .58), indicating that there was no statistically significant difference in the rate of development of recurrent painful nail borders between the two procedures.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    This retrospective medical record review demonstrated little difference between these chemicals in their reoperation and recurrence rates.\n                  <\/jats:p>","DOI":"10.7547\/23-081","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:58:24Z","timestamp":1756313904000},"source":"Crossref","is-referenced-by-count":1,"title":["Sodium Hydroxide versus Phenol Chemical Matrixectomy"],"prefix":"10.3390","volume":"115","author":[{"given":"Clark K.","family":"Brackney","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery and Rehabilitation, Wake Forest University School of Medicine, Atrium Wake Forest Baptist Medical Center, Winston-Salem, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Kipp","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Rehabilitation, Wake Forest University School of Medicine, Atrium Wake Forest Baptist Medical Center, Winston-Salem, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Russell","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine, Atrium Wake Forest Baptist Medical Center, Winston-Salem, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody D.","family":"Blazek","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Rehabilitation, Wake Forest University School of Medicine, and Department of Vascular and Endovascular Surgery, Atrium Wake Forest Baptist Medical Center, Winston-Salem, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Powers","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Rehabilitation, Wake Forest University School of Medicine, Atrium Wake Forest Baptist Medical Center, Winston-Salem, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashleigh W.","family":"Medda","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Rehabilitation, Wake Forest University School of Medicine, Atrium Wake Forest Baptist Medical Center, Winston-Salem, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"B1","series-title":"Clin Dermatol","first-page":"516","article-title":"Nail surgery","volume":"31","author":"Haneke E","year":"2013","unstructured":"Haneke E: Nail surgery. Clin Dermatol 31: 516, 2013."},{"key":"B2","series-title":"J Dermatol Surg Oncol","first-page":"331","article-title":"Chemocautery for ingrown toenails","volume":"7","author":"Brown FC","year":"1981","unstructured":"Brown FC: Chemocautery for ingrown toenails. J Dermatol Surg Oncol 7: 331, 1981."},{"key":"B3","series-title":"JAPMA","first-page":"452","article-title":"Improved healing with a collagen-alginate dressing in the chemical matricectomy","volume":"88","author":"Van Gils CC","year":"1998","unstructured":"Van Gils CC, Roeder B, Chesler SM, et al: Improved healing with a collagen-alginate dressing in the chemical matricectomy. JAPMA 88: 452, 1998."},{"key":"B4","series-title":"Scott Med J","first-page":"236","article-title":"Phenol cauterization in the management of ingrowing toenails","volume":"27","author":"Robb JE","year":"1982","unstructured":"Robb JE, Murray WR: Phenol cauterization in the management of ingrowing toenails. 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JAPMA 104: 649, 2014."},{"key":"B7","series-title":"Acta Derm Venereol","first-page":"adv00065","article-title":"Comparison of chemical matricectomy with trichloroacetic acid, phenol, or sodium hydroxide for ingrown toenails: a systematic review and network meta-analysis","volume":"100","author":"Chang HC","year":"2020","unstructured":"Chang HC, Lin MH: Comparison of chemical matricectomy with trichloroacetic acid, phenol, or sodium hydroxide for ingrown toenails: a systematic review and network meta-analysis. Acta Derm Venereol 100: adv00065, 2020."},{"key":"B8","series-title":"Dermatol Surg","first-page":"219","article-title":"Chemical matricectomy with 10% sodium hydroxide for the treatment of ingrown toenails in people with diabetes","volume":"36","author":"Tatlican S","year":"2010","unstructured":"Tatlican S, Eren C, Yamangokturk B, et al: Chemical matricectomy with 10% sodium hydroxide for the treatment of ingrown toenails in people with diabetes. Dermatol Surg 36: 219, 2010."},{"key":"B9","series-title":"Dermatol Surg","first-page":"432","article-title":"Letter: retrospective comparison of experiences with phenol and sodium hydroxide in the treatment of ingrown nail","volume":"36","author":"Tatlican S","year":"2010","unstructured":"Tatlican S, Eren C, Yamangokturk B, et al: Letter: retrospective comparison of experiences with phenol and sodium hydroxide in the treatment of ingrown nail. Dermatol Surg 36: 432, 2010."},{"key":"B10","series-title":"Ann R Coll Surg Engl","first-page":"99","article-title":"Surgical treatment of ingrown toenails in children: what is best practice?","volume":"93","author":"Mitchell S","year":"2011","unstructured":"Mitchell S, Jackson CR, Wilson-Storey D: Surgical treatment of ingrown toenails in children: what is best practice? Ann R Coll Surg Engl 93: 99, 2011."},{"key":"B11","series-title":"Indian J Dermatol Venereol Leprol","first-page":"472","article-title":"Controlled trial comparing the efficacy of 88% phenol versus 10% sodium hydroxide for chemical matricectomy in the management of ingrown toenail","volume":"81","author":"Grover C","year":"2015","unstructured":"Grover C, Khurana A, Bhattacharya SN, et al: Controlled trial comparing the efficacy of 88% phenol versus 10% sodium hydroxide for chemical matricectomy in the management of ingrown toenail. Indian J Dermatol Venereol Leprol 81: 472, 2015."},{"key":"B12","series-title":"Dermatol Surg","first-page":"680","article-title":"Comparison of phenol and sodium hydroxide chemical matrixectomies for the treatment of ingrowing toenails","volume":"33","author":"Bostanci S","year":"2007","unstructured":"Bostanci S, Kocyigit P, G\u00fcrgey E: Comparison of phenol and sodium hydroxide chemical matrixectomies for the treatment of ingrowing toenails. Dermatol Surg 33: 680, 2007."}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/115\/4\/23-081.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/115\/4\/23-081.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/115\/4\/23-081.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:20:14Z","timestamp":1783506014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/115\/4\/23081"}},"subtitle":["A Comparative Retrospective Medical Record Review"],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":12,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.7547\/23-081","relation":{},"ISSN":["8750-7315"],"issn-type":[{"value":"8750-7315","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}