{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:14:36Z","timestamp":1784034876116,"version":"3.55.0"},"reference-count":7,"publisher":"MDPI AG","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>\n                    <jats:italic>Mycobacterium abscessus<\/jats:italic>\n                    complex (MAbc) is a rapidly growing nontuberculous mycobacterium that represents an increasingly prevalent cause of skin infections. This report describes an atypical presentation of MAbc to heighten physician awareness of the pathogen. A 69-year-old woman with immunocompromised status presented with a 4-month history of a solitary, nonhealing ulcer on her right lower extremity after an insect bite. After no improvement following oral amoxicillin\/clavulanate and topical mupirocin for the initial diagnosis of cellulitis, biopsy and culture of the lesion revealed MAbc. Microscopic examination revealed reactive cutaneous inflammation without evidence of malignancy. Acid-fast bacteria (AFB) stain was negative, and no granulomas were noted histologically. Clarithromycin and doxycycline were initiated while awaiting susceptibility testing results. Final culture showed MAbc sensitive to amikacin, cefoxitin, and clarithromycin. Unfortunately, before antibiotic therapy could be modified, the patient died. The presentation of a solitary lower-extremity ulcer is rare compared with current literature. This case occurred after a suspected insect bite rather than instrumentation. In addition, this case demonstrated negative AFB stain and absence of granulomas on histologic analysis. The patient\u2019s death did not allow for evaluation of treatment efficacy. Existing literature characterizing MAbc is sparse. Most cases present as multiple papules, nodules, and abscesses with positive AFB staining and granulomas; it is possible for deviations to exist depending on host immune status. Considering the highly drug-resistant nature of\n                    <jats:italic>M abscessus,<\/jats:italic>\n                    prompt diagnosis and treatment are crucial. For this to occur, clinicians must maintain high clinical suspicion for\n                    <jats:italic>M abscessus<\/jats:italic>\n                    infection in any chronic, nonhealing wound failing to respond to initial treatment.\n                  <\/jats:p>","DOI":"10.7547\/23-134","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T11:27:52Z","timestamp":1725535672000},"source":"Crossref","is-referenced-by-count":3,"title":["Mycobacterium abscessus Cutaneous Infection in the Immunosuppressed: A Case Report on an Atypical Pathogen"],"prefix":"10.3390","volume":"114","author":[{"given":"Caden","family":"Carver","sequence":"first","affiliation":[{"name":"Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigar","family":"Patel","sequence":"additional","affiliation":[{"name":"Arizona College of Podiatric Medicine, Midwestern University, Glendale, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Mariano","sequence":"additional","affiliation":[{"name":"Arizona College of Podiatric Medicine, Midwestern University, Glendale, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattie","family":"Krause","sequence":"additional","affiliation":[{"name":"Arizona College of Podiatric Medicine, Midwestern University, Glendale, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Heigh-Rosen","sequence":"additional","affiliation":[{"name":"Arizona College of Podiatric Medicine, Midwestern University, Glendale, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"B1","series-title":"Eur J Clin Microbiol Infect Dis","first-page":"161","article-title":"Clinical and laboratory aspects of the diagnosis and management of cutaneous and subcutaneous infections caused by rapidly growing mycobacteria","volume":"32","author":"Kothavade RJ","year":"2013","unstructured":"Kothavade RJ, Dhurat RS, Mishra SN, et al: Clinical and laboratory aspects of the diagnosis and management of cutaneous and subcutaneous infections caused by rapidly growing mycobacteria. Eur J Clin Microbiol Infect Dis 32: 161, 2013."},{"key":"B2","series-title":"Emerg Infect Dis","first-page":"1638","article-title":"Mycobacterium abscessus complex infections in humans","volume":"21","author":"Lee MR","year":"2015","unstructured":"Lee MR, Sheng WH, Hung CC, et al: Mycobacterium abscessus complex infections in humans. Emerg Infect Dis 21: 1638, 2015."},{"key":"B3","series-title":"J Cutaneous Pathol","first-page":"124","article-title":"Cutaneous infections due to nontuberculous mycobacteria: histopathological review of 28 cases: comparative study between lesions observed in immunosuppressed patients and normal hosts","volume":"27","author":"Bartralot R","year":"2000","unstructured":"Bartralot R, Pujol RM, Garc\u00eda-Patos V, et al: Cutaneous infections due to nontuberculous mycobacteria: histopathological review of 28 cases: comparative study between lesions observed in immunosuppressed patients and normal hosts. J Cutaneous Pathol 27: 124, 2000."},{"key":"B4","series-title":"Front Med (Lausanne)","article-title":"Clinical characteristics and mortality of non-tuberculous mycobacterial infection in immunocompromised vs. immunocompetent hosts","volume":"9","author":"Chai J","year":"2022","unstructured":"Chai J, Han X, Mei Q, et al: Clinical characteristics and mortality of non-tuberculous mycobacterial infection in immunocompromised vs. immunocompetent hosts. Front Med (Lausanne) 9: 884446, 2022."},{"key":"B5","series-title":"Dermatol Clin","first-page":"563","article-title":"Nontuberculous mycobacteria: skin and soft tissue infections","volume":"33","author":"Gonzalez-Santiago TM","year":"2015","unstructured":"Gonzalez-Santiago TM, Drage LA: Nontuberculous mycobacteria: skin and soft tissue infections. Dermatol Clin 33: 563, 2015."},{"key":"B6","series-title":"Dermatol Rep","first-page":"25","article-title":"Two episodes of cutaneous non tuberculous mycobacterial infection in a patient with psoriasis","volume":"7","author":"Chan WSA","year":"2015","unstructured":"Chan WSA, Shang-Ian T, Nisha Su Yien C, et al: Two episodes of cutaneous non tuberculous mycobacterial infection in a patient with psoriasis. Dermatol Rep 7: 25, 2015."},{"key":"B7","series-title":"Adv Wound Care (New Rochelle)","first-page":"560","article-title":"Challenges in the treatment of chronic wounds","volume":"4","author":"Frykberg RG","year":"2015","unstructured":"Frykberg RG, Banks J: Challenges in the treatment of chronic wounds. Adv Wound Care (New Rochelle) 4: 560, 2015."}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/114\/4\/23-134.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/114\/4\/23-134.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/114\/4\/23-134.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:19:47Z","timestamp":1783505987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/114\/4\/23134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":7,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.7547\/23-134","relation":{},"ISSN":["8750-7315"],"issn-type":[{"value":"8750-7315","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]}}}