{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:15:05Z","timestamp":1783509305592,"version":"3.55.0"},"reference-count":30,"publisher":"MDPI AG","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Osteomyelitis (OM) is a complex bone disease most often caused by microorganism-based infections; it poses significant challenges for diagnosis and treatment. Previous epidemiologic studies have identified upward temporal trends in the diagnosis of OM. This study examined these trends in diabetic OM and OM-related amputations in Texas, a state with one of the highest rates of diabetes in the United States.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Retrospective analysis was conducted on Texas diabetic inpatient hospital data from 2006 to 2016. Data were extracted for patients who had diagnostic codes for diabetes and for foot and ankle OM, along with data for OM-related major or minor amputations. Rates were calculated per 1,000 people and standardized using 2019 population estimates.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The prevalence of diabetic OM increased from 2006 to 2016, as did total, major, and minor amputations in patients with OM. Decreases were noted in 2014 to 2016. Age-standardized rates demonstrated the same trends, as did rates across all of the age groups. Osteomyelitis increased most in 45- to 64-year-olds. Amputation rates increased similarly in 45- to 64-year-olds, 65- to 74-year-olds, and those 75 years and older. Poisson regression analysis reinforced these trends, with significant increases in risk ratios for OM and amputation rates in all of the age groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    This preliminary analysis highlights the increasing prevalence of OM and OM-related amputations in diabetic patients from 2006 to 2016 and for all age groups (18\u201375 years and older) in Texas. Although increasing diabetes rates may contribute to the observed trends in OM, it does not exclusively explain them. Further research should investigate possible interventions to mitigate the rise in diabetic OM and associated amputations.\n                  <\/jats:p>","DOI":"10.7547\/23-192","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T14:39:50Z","timestamp":1765895990000},"source":"Crossref","is-referenced-by-count":0,"title":["Osteomyelitis and Osteomyelitis-Related Amputations in Texas Diabetic Populations"],"prefix":"10.3390","volume":"115","author":[{"given":"Daniel C.","family":"Jupiter","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Data Science, The University of Texas Medical Branch, Galveston, TX."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina M.","family":"Pescatore","sequence":"additional","affiliation":[{"name":"John Sealy School of Medicine, The University of Texas Medical Branch, Galveston, TX."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"B1","series-title":"Lancet","first-page":"369","article-title":"Osteomyelitis","volume":"364","author":"Lew DP","year":"2004","unstructured":"Lew DP, Waldvogel FA: Osteomyelitis. Lancet 364: 369, 2004."},{"key":"B2","series-title":"Conn\u2019s Current Therapy","first-page":"1010","article-title":"Osteomyelitis","author":"Mader JT","year":"2002","unstructured":"Mader JT, Wang J, Shirtliff ME, et al: \u201cOsteomyelitis,\u201d in Conn\u2019s Current Therapy, edited by RE Rakel, ET Bope, p 1010, WB Saunders, Philadelphia, 2002."},{"key":"B3","series-title":"Infect Dis Clin North Am","first-page":"325","article-title":"Osteomyelitis","volume":"31","author":"Schmitt SK","year":"2017","unstructured":"Schmitt SK: Osteomyelitis. Infect Dis Clin North Am 31: 325, 2017."},{"key":"B4","series-title":"Diabetologia","first-page":"18","article-title":"High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe: baseline results from the Eurodiale study","volume":"50","author":"Prompers L","year":"2007","unstructured":"Prompers L, Huijberts M, Apelqvist J, et al: High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe: baseline results from the Eurodiale study. Diabetologia 50: 18, 2007."},{"key":"B5","series-title":"Phys Sportsmed","first-page":"nihpa116823","article-title":"Osteomyelitis: approach to diagnosis and treatment","volume":"36","author":"Fritz JM","year":"2008","unstructured":"Fritz JM, McDonald JR: Osteomyelitis: approach to diagnosis and treatment. Phys Sportsmed 36: nihpa116823, 2008."},{"key":"B6","series-title":"Diabetes Res Clin Pract","first-page":"123","article-title":"Prevalence of osteomyelitis in non-healing diabetic foot ulcers: usefulness of radiologic and scintigraphic findings","volume":"38","author":"Balsells M","year":"1997","unstructured":"Balsells M, Viad\u00e9 J, Mill\u00e1n M, et al: Prevalence of osteomyelitis in non-healing diabetic foot ulcers: usefulness of radiologic and scintigraphic findings. Diabetes Res Clin Pract 38: 123, 1997."},{"key":"B7","series-title":"Diabetes Metab","first-page":"87","article-title":"Diabetic foot osteomyelitis","volume":"34","author":"Hartemann-Heurtier A","year":"2008","unstructured":"Hartemann-Heurtier A, Senneville E: Diabetic foot osteomyelitis. Diabetes Metab 34: 87, 2008."},{"key":"B8","series-title":"Foot Ankle Clin","first-page":"569","article-title":"Osteomyelitis of the foot and ankle: diagnosis, epidemiology, and treatment","volume":"19","author":"Lindbloom BJ","year":"2014","unstructured":"Lindbloom BJ, James ER, McGarvey WC: Osteomyelitis of the foot and ankle: diagnosis, epidemiology, and treatment. Foot Ankle Clin 19: 569, 2014."},{"key":"B9","series-title":"J Foot Ankle Surg","first-page":"722","article-title":"Clinical outcomes of foot infections in patients without diabetes","volume":"59","author":"Ryan EC","year":"2020","unstructured":"Ryan EC, Crisologo PA, La Fontaine J, et al: Clinical outcomes of foot infections in patients without diabetes. J Foot Ankle Surg 59: 722, 2020."},{"key":"B10","series-title":"J Foot Ankle Res","first-page":"6","article-title":"Characteristics of non-diabetic foot ulcers in Western Sydney, Australia","volume":"9","author":"Haji Zaine N","year":"2016","unstructured":"Haji Zaine N, Hitos K, Vicaretti M, et al: Characteristics of non-diabetic foot ulcers in Western Sydney, Australia. J Foot Ankle Res 9: 6, 2016."},{"key":"B11","series-title":"J Wound Care","first-page":"445","article-title":"Foot ulceration in a non-diabetic population: a cross-sectional audit of staff in one health district","volume":"17","author":"Bristow I","year":"2008","unstructured":"Bristow I: Foot ulceration in a non-diabetic population: a cross-sectional audit of staff in one health district. J Wound Care 17: 445, 2008."},{"key":"B12","series-title":"Expert Rev Pharmacoecon Outcomes Res","first-page":"279","article-title":"Current health and economic burden of chronic diabetic osteomyelitis","volume":"19","author":"Geraghty T","year":"2019","unstructured":"Geraghty T, LaPorta G: Current health and economic burden of chronic diabetic osteomyelitis. Expert Rev Pharmacoecon Outcomes Res 19: 279, 2019."},{"key":"B13","series-title":"Diabetes Care","first-page":"1333","article-title":"A cost analysis of diabetic lower-extremity ulcers","volume":"23","author":"Harrington C","year":"2000","unstructured":"Harrington C, Zagari MJ, Corea J, et al: A cost analysis of diabetic lower-extremity ulcers. Diabetes Care 23: 1333, 2000."},{"key":"B14","series-title":"Expert Rev Pharmacoecon Outcomes Res","first-page":"165","article-title":"Losing a foot versus losing a dollar; a systematic review of cost studies in diabetic foot complications","volume":"17","author":"Petrakis I","year":"2017","unstructured":"Petrakis I, Kyriopoulos IJ, Ginis A, et al: Losing a foot versus losing a dollar; a systematic review of cost studies in diabetic foot complications. Expert Rev Pharmacoecon Outcomes Res 17: 165, 2017."},{"key":"B15","article-title":"Centers for Disease Control and Prevention","year":"2023","unstructured":"Centers for Disease Control and Prevention: National and state diabetes trends. Centers for Disease Control and Prevention. Available at: https:\/\/www.cdc.gov\/diabetes\/library\/reports\/reportcard\/national-state-diabetes-trends.html. Accessed August 30, 2023."},{"key":"B16","series-title":"J Clin Orthop Trauma","first-page":"88","article-title":"The current burden of diabetic foot disease","volume":"17","author":"Edmonds M","year":"2021","unstructured":"Edmonds M, Manu C, Vas P: The current burden of diabetic foot disease. J Clin Orthop Trauma 17: 88, 2021."},{"key":"B17","article-title":"Hospital discharge data public use data file","year":"2023","unstructured":"Texas Health and Human Services: Hospital discharge data public use data file. Available at: https:\/\/www.dshs.texas.gov\/THCIC\/Hospitals\/Download.shtm. Published 2021. Accessed August 30, 2023."},{"key":"B18","article-title":"Population and housing unit estimates","year":"2023","unstructured":"US Census Bureau: Population and housing unit estimates. Available at: https:\/\/www.census.gov\/popest\/. Published 2022. Accessed August 30, 2023."},{"key":"B19","article-title":"Medicare Part D in 2018: the latest on enrollment, premiums, and cost sharing 2018. KFF","author":"Cubanski J","unstructured":"Cubanski J, Damico A, Neuman T: Medicare Part D in 2018: the latest on enrollment, premiums, and cost sharing 2018. KFF. Available at: https:\/\/www.kff.org\/medicare\/issue-brief\/medicare-part-d-in-2018-the-latest-on-enrollment-premiums-and-cost-sharing\/. Published May 17, 2018. Accessed August 30, 2023."},{"key":"B20","series-title":"World J Diabetes","first-page":"135","article-title":"Osteomyelitis in diabetic foot: a comprehensive overview","volume":"8","author":"Giurato L","year":"2017","unstructured":"Giurato L, Meloni M, Izzo V, et al: Osteomyelitis in diabetic foot: a comprehensive overview. World J Diabetes 8: 135, 2017."},{"key":"B21","year":"2023","unstructured":"DataUSA: Hidalgo County, TX. Available at: https:\/\/datausa.io\/profile\/geo\/hidalgo-county-tx\/. Published 2020. Accessed August 30, 2023."},{"key":"B22","series-title":"J Diabetes Complications","first-page":"254","article-title":"Deep foot infections in patients with diabetes and foot ulcer: an entity with different characteristics, treatments, and prognosis","volume":"13","author":"Eneroth M","year":"1999","unstructured":"Eneroth M, Larsson J, Apelqvist J: Deep foot infections in patients with diabetes and foot ulcer: an entity with different characteristics, treatments, and prognosis. J Diabetes Complications 13: 254, 1999."},{"key":"B23","series-title":"The Diabetic Foot","first-page":"59","article-title":"Clinical Examination and Risk Classification of the Diabetic Foot","author":"Lavery LA","year":"2012","unstructured":"Lavery LA, Armstrong DG: \u201cClinical Examination and Risk Classification of the Diabetic Foot,\u201d in The Diabetic Foot, ed by A Veves, JM Giurini, FW LoGerfo, p 59, Humana Press, Totowa, NJ, 2012."},{"key":"B24","year":"2023","unstructured":"KFF: Population distribution by age. Available at: https:\/\/www.kff.org\/other\/state-indicator\/distribution-by-age\/. Published 2022. Accessed August 30, 2023."},{"key":"B25","article-title":"Diabetes in Texas","year":"2018","unstructured":"Texas Demographic Center: Diabetes in Texas. Available at: https:\/\/www.demographics.texas.gov\/Resources\/publications\/2018\/2018_12_17_DiabetesProfile.pdf. Published 2018. Accessed August 30, 2023."},{"key":"B26","article-title":"2023 demographics","year":"2023","unstructured":"RGV Health Connect: 2023 demographics. Available at: https:\/\/www.rgvhealthconnect.org\/demographicdata?id=281259&sectionId=935. Published 2023. Accessed August 30, 2023."},{"key":"B27","series-title":"Am J Med Sci","first-page":"274","article-title":"Diabetes mellitus in the Hispanic\/Latino population: an increasing health care challenge in the United States","volume":"334","author":"Umpierrez GE","year":"2007","unstructured":"Umpierrez GE, Gonzalez A, Umpierrez D, et al: Diabetes mellitus in the Hispanic\/Latino population: an increasing health care challenge in the United States. Am J Med Sci 334: 274, 2007."},{"key":"B28","year":"2023","unstructured":"Centers for Disease Control and Prevention: Behavioral Risk Factor Surveillance System. Available at: https:\/\/www.cdc.gov\/brfss\/index.html. Published 2023. Accessed August 30, 2023."},{"key":"B29","series-title":"JAMA Surg","first-page":"84","article-title":"Fifteen-year trends in lower limb amputation, revascularization, and preventive measures among medicare patients","volume":"150","author":"Goodney PP","year":"2015","unstructured":"Goodney PP, Tarulli M, Faerber AE, et al: Fifteen-year trends in lower limb amputation, revascularization, and preventive measures among medicare patients. JAMA Surg 150: 84, 2015."},{"key":"B30","article-title":"2008 to 2016 interactive dot plot","year":"2017","unstructured":"US Census Bureau: Population without health insurance coverage by state: 2008 to 2016 interactive dot plot. Available at: https:\/\/www.census.gov\/library\/visualizations\/interactive\/health-insurance-dotplot.html. Published September 25, 2017. Accessed May 14, 2024."}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/japmaonline.org\/view\/journals\/apms\/115\/6\/23-192.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/115\/6\/23-192.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/japmaonline.org\/downloadpdf\/journals\/apms\/115\/6\/23-192.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:20:26Z","timestamp":1783506026000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/115\/6\/23192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":30,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.7547\/23-192","relation":{},"ISSN":["8750-7315"],"issn-type":[{"value":"8750-7315","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}