{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:16:40Z","timestamp":1783430200983,"version":"3.54.6"},"reference-count":0,"publisher":"MDPI AG","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,7,1]]},"abstract":"<jats:p>Xerosis is defined as dehydration of skin characterized by redness, dry scaling, and fine crackling that may resemble the crackling of porcelain. The present double-blind trial was a randomized paired comparison study evaluating the keratolytic effect of 5% salicylic acid and 10% urea ointment (Kerasal) on one foot and 12% ammonium lactate lotion (Lac-Hydrin) on the other foot in mild-to-moderate xerosis. Seventy patients were initially enrolled in the trial. Fifty-four patients were evaluated after 2 weeks of treatment; of those 54 patients, 39 were evaluated after 4 weeks of treatment. Although there was significant improvement in severity of xerosis after 2 and 4 weeks of treatment, there was no statistically significant difference between treatment groups. Irrespective of the mechanism of action, this study shows that both Kerasal and Lac-Hydrin 12% lotion result in reduction in the severity of xerosis after 4 weeks of therapy.<\/jats:p>","DOI":"10.7547\/87507315-88-7-332","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T11:07:44Z","timestamp":1396350464000},"page":"332-336","source":"Crossref","is-referenced-by-count":26,"title":["Comparison of salicylic acid and urea versus ammonium lactate for the treatment of foot xerosis. A randomized, double-blind, clinical study"],"prefix":"10.3390","volume":"88","author":[{"given":"MB","family":"Jennings","sequence":"first","affiliation":[{"name":"New York College of Podiatric Medicine, NY 10035, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Alfieri","sequence":"first","affiliation":[{"name":"New York College of Podiatric Medicine, NY 10035, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Ward","sequence":"first","affiliation":[{"name":"New York College of Podiatric Medicine, NY 10035, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Lesczczynski","sequence":"first","affiliation":[{"name":"New York College of Podiatric Medicine, NY 10035, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/japma\/article-pdf\/88\/7\/332\/1411616\/87507315-88-7-332.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/japma\/article-pdf\/88\/7\/332\/1411616\/87507315-88-7-332.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:44:11Z","timestamp":1783428251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/88\/7\/332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1998,7,1]]}},"URL":"https:\/\/doi.org\/10.7547\/87507315-88-7-332","relation":{},"ISSN":["8750-7315","1930-8264"],"issn-type":[{"value":"8750-7315","type":"print"},{"value":"1930-8264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,7,1]]}}}