{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:06:09Z","timestamp":1788537969442,"version":"build-2803163510"},"reference-count":26,"publisher":"MDPI AG","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"\n Background:<\/jats:bold>\n Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus (DM) that causes substantial morbidities, including pain, foot ulcers, lower-limb amputations, and depression. It is said to affect approximately 50% of adults with DM. Understanding the predictors of DPN will help refocus on early preventive strategies to reduce its numerous morbidities.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n A total of 1,040 persons with DM were consecutively enrolled. Relevant medical history, clinical examinations, and laboratory investigations were performed. Multiple logistic regression was used to determine predictors of DPN. Significance was set at\n P<\/jats:italic>\n \u2264 .05.\n <\/jats:p>\n \n Results:<\/jats:bold>\n Significant predictors of DPN included age (odds ratio [OR], 1.99;\n P<\/jats:italic>\n = .003); female sex (OR, 1.94;\n P<\/jats:italic>\n = .023); DM duration (OR, 2.01;\n P<\/jats:italic>\n = .032); history of systemic hypertension (OR, 1.68;\n P<\/jats:italic>\n = .037); height (OR, 2.02;\n P<\/jats:italic>\n = .001); generalized obesity (OR, 2.02;\n P<\/jats:italic>\n = .002); central obesity (OR, 1.12;\n P<\/jats:italic>\n = .047); poor control of systolic blood pressure (OR, 1.78;\n P<\/jats:italic>\n = .001), diastolic blood pressure (OR, 1.45;\n P<\/jats:italic>\n = .006), fasting plasma glucose (OR, 2.43;\n P<\/jats:italic>\n = .004), 2-hour postprandial glucose (2HrPP) (OR, 2.83;\n P<\/jats:italic>\n = .001), and glycated hemoglobin (OR, 2.31;\n P<\/jats:italic>\n = .004); and peripheral artery disease (OR, 1.89;\n P<\/jats:italic>\n = .002). The negative predictors of DPN include antidiabetics (OR, 2.39;\n P<\/jats:italic>\n = .008), antihypertensives (OR, 2.45;\n P<\/jats:italic>\n = .009), statins (OR, 2.21;\n P<\/jats:italic>\n = .004), and antiplatelets (OR, 2.46;\n P<\/jats:italic>\n = .030).\n <\/jats:p>\n \n Conclusions:<\/jats:bold>\n Significant predictors of DPN include age, DM duration, female sex, height, history of systemic hypertension, and obesity. Others include poor control of systolic and diastolic blood pressure, fasting plasma glucose, 2HrPP, and glycated hemoglobin levels. Negative predictors include antidiabetics, antihypertensives, statins, and antiplatelets.\n <\/jats:p>","DOI":"10.7547\/l22-053","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T10:41:14Z","timestamp":1742812874000},"source":"Crossref","is-referenced-by-count":3,"title":["Predictors of Peripheral Neuropathy Among Persons with Diabetes Mellitus: A Multicenter Cross-Sectional Study"],"prefix":"10.3390","volume":"115","author":[{"given":"Yakubu","family":"Lawal","sequence":"first","affiliation":[{"name":"College of Health Sciences, University of Abuja, Abuja, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rifkatu","family":"Mshelia-Reng","sequence":"additional","affiliation":[{"name":"College of Health Sciences, University of Abuja, Abuja, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Special Odiase","family":"Omonua","sequence":"additional","affiliation":[{"name":"College of Health Sciences, University of Abuja, Abuja, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenechukwu","family":"Odumodu","sequence":"additional","affiliation":[{"name":"College of Health Sciences, University of Abuja, Abuja, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramatu","family":"Shuaibu","sequence":"additional","affiliation":[{"name":"College of Health Sciences, University of Abuja, Abuja, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ukamaka Dorothy","family":"Itanyi","sequence":"additional","affiliation":[{"name":"College of Health Sciences, University of Abuja, Abuja, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina Ibrahim","family":"Abubakar","sequence":"additional","affiliation":[{"name":"College of Health Sciences, University of Abuja, Abuja, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadijat Oluseyi","family":"Kolade-Yunusa","sequence":"additional","affiliation":[{"name":"College of Health Sciences, University of Abuja, Abuja, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zumnan Songden","family":"David","sequence":"additional","affiliation":[{"name":"College of Health Sciences, University of Abuja, Abuja, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babajide","family":"Ogunlana","sequence":"additional","affiliation":[{"name":"Memorial Hermann Southwest Hospital, Houston, TX."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Clarke","sequence":"additional","affiliation":[{"name":"Andrew Clarke Podiatry Clinic, Claremont, Cape Town, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufemi","family":"Adediran","sequence":"additional","affiliation":[{"name":"College of Health Sciences, University of Abuja, Abuja, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb O.","family":"Ehusani","sequence":"additional","affiliation":[{"name":"Mark Anumah Medical Mission, Abuja, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulfiqarali","family":"Abbas","sequence":"additional","affiliation":[{"name":"Muhimbili University College of Health Science and Abbas Medical Centre, Dar es Salaam, Tanzania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia Ehusani","family":"Anumah","sequence":"additional","affiliation":[{"name":"College of Health Sciences, University of Abuja, Abuja, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","reference":[{"key":"B1","series-title":"J Diabetes Res","first-page":"9562920","article-title":"Prevalence and determinants of peripheral neuropathy among type 2 adult diabetes patients attending Jimma University Medical Center, Southwest Ethiopia, 2019, an institutional-based cross-sectional study","volume":"2020","author":"Abdissa D","year":"2020","unstructured":"Abdissa D, Hamba N, Kene K, et al: Prevalence and determinants of peripheral neuropathy among type 2 adult diabetes patients attending Jimma University Medical Center, Southwest Ethiopia, 2019, an institutional-based cross-sectional study. 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