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Little is known about how cell fate diversification is linked to synaptic target choices. Here we investigate how presynaptic neurons select one type of muscles, vm2, as a synaptic target and form synapses on its dendritic spine-like muscle arms. We found that the Notch-Delta pathway was required to distinguish target from non-target muscles. APX-1\/Delta acts in surrounding cells including the non-target vm1 to activate LIN-12\/Notch in the target vm2. LIN-12 functions cell-autonomously to up-regulate the expression of UNC-40\/DCC and MADD-2 in vm2, which in turn function together to promote muscle arm formation and guidance. Ectopic expression of UNC-40\/DCC in non-target vm1 muscle is sufficient to induce muscle arm extension from these cells. Therefore, the LIN-12\/Notch signaling specifies target selection by selectively up-regulating guidance molecules and forming muscle arms in target cells.<\/jats:p>","DOI":"10.7554\/elife.00378","type":"journal-article","created":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T08:11:38Z","timestamp":1363680698000},"source":"Crossref","is-referenced-by-count":30,"title":["LIN-12\/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40\/DCC and MADD-2 in Caenorhabditis elegans"],"prefix":"10.7554","volume":"2","author":[{"given":"Pengpeng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Koelle","sequence":"additional","affiliation":[{"name":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2013,3,19]]},"reference":[{"key":"bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0925-4773(95)00425-4","article-title":"Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells","volume":"53","author":"Ahmad","year":"1995","journal-title":"Mech 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