{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:50:14Z","timestamp":1791352214601,"version":"4.3.1"},"reference-count":71,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T00:00:00Z","timestamp":1365465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T00:00:00Z","timestamp":1365465600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T00:00:00Z","timestamp":1365465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P01HL057346, R01HL039693"],"award-info":[{"award-number":["P01HL057346, R01HL039693"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["10POST4150049"],"award-info":[{"award-number":["10POST4150049"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2013,2,19]]},"abstract":"<jats:p>\n                    The secretory pathway of eukaryotic cells packages cargo proteins into COPII-coated vesicles for transport from the endoplasmic reticulum (ER) to the Golgi. We now report that complete genetic deficiency for the COPII component SEC24A is compatible with normal survival and development in the mouse, despite the fundamental role of SEC24 in COPII vesicle formation and cargo recruitment. However, these animals exhibit markedly reduced plasma cholesterol, with mutations in\n                    <jats:italic>Apoe<\/jats:italic>\n                    and\n                    <jats:italic>Ldlr<\/jats:italic>\n                    epistatic to\n                    <jats:italic>Sec24a<\/jats:italic>\n                    , suggesting a receptor-mediated lipoprotein clearance mechanism. Consistent with these data, hepatic LDLR levels are up-regulated in SEC24A-deficient cells as a consequence of specific dependence of PCSK9, a negative regulator of LDLR, on SEC24A for efficient exit from the ER. Our findings also identify partial overlap in cargo selectivity between SEC24A and SEC24B, suggesting a previously unappreciated heterogeneity in the recruitment of secretory proteins to the COPII vesicles that extends to soluble as well as trans-membrane cargoes.\n                  <\/jats:p>","DOI":"10.7554\/elife.00444","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T11:20:52Z","timestamp":1365506452000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.00444","source":"Crossref","is-referenced-by-count":115,"title":["SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion"],"prefix":"10.7554","volume":"2","author":[{"given":"Xiao-Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Life Sciences Institute, University of Michigan","place":["Ann Arbor, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan","place":["Ann Arbor, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanika","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California, Berkeley","place":["Berkeley, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California, Berkeley","place":["Berkeley, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo-Xian","family":"Meng","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan","place":["Ann Arbor, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danjun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Wayne State University","place":["Detroit, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, University of Michigan","place":["Ann Arbor, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Cleveland Clinic","place":["Cleveland, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Adams","sequence":"additional","affiliation":[{"name":"Program in Cell and Molecular Biology, University of Michigan","place":["Ann Arbor, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Baines","sequence":"additional","affiliation":[{"name":"Program in Cell and Molecular Biology, University of Michigan","place":["Ann Arbor, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genggeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan","place":["Ann Arbor, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen A","family":"Sartor","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, University of Michigan","place":["Ann Arbor, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Cleveland Clinic","place":["Cleveland, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengping","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Wayne State University","place":["Detroit, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandie","family":"Lin","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan","place":["Ann Arbor, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Medicine and Human Genetics, University of California, Los Angeles","place":["Los Angeles, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Schekman","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley","place":["Berkeley, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ginsburg","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine & Genetics, Howard Hughes Medical Institute, University of Michigan","place":["Ann Arbor, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2013,4,9]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1399-0004.2007.00759.x","type":"journal-article","article-title":"SIL1 and SARA2 mutations in Marinesco-Sjogren and chylomicron retention diseases","volume":"71","author":"Annesi","year":"2007","journal-title":"Clin Genet"},{"key":"bib2","article-title":"Mammalian SEC24D deficiency leads to embryonic lethality","volume-title":"PLOS One","author":"Baines","type":"other"},{"key":"bib3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","type":"journal-article","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Benjamini","year":"2001","journal-title":"Behav Brain Res"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nature01040","type":"journal-article","article-title":"Structure of the Sec23\/24-Sar1 pre-budding complex of the COPII vesicle coat","volume":"419","author":"Bi","year":"2002","journal-title":"Nature"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1002\/humu.21077","type":"journal-article","article-title":"Congenital dyserythropoietic anemia type II (CDAII) is caused by mutations in the SEC23B gene","volume":"30","author":"Bianchi","year":"2009","journal-title":"Hum Mutat"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.sbi.2004.02.002","type":"journal-article","article-title":"A structural view of the COPII vesicle coat","volume":"14","author":"Bickford","year":"2004","journal-title":"Curr Opin Struct Biol"},{"key":"bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0092-8674(03)01079-1","type":"journal-article","article-title":"The mechanisms of vesicle budding and fusion","volume":"116","author":"Bonifacino","year":"2004","journal-title":"Cell"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1038\/ng1876","type":"journal-article","article-title":"Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking","volume":"38","author":"Boyadjiev","year":"2006","journal-title":"Nat Genet"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1399-0004.2010.01550.x","type":"journal-article","article-title":"Cranio-lenticulo-sutural dysplasia associated with defects in collagen secretion","volume":"80","author":"Boyadjiev","year":"2010","journal-title":"Clin Genet"},{"key":"bib10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(00)80213-5","type":"journal-article","article-title":"The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor","volume":"89","author":"Brown","year":"1997","journal-title":"Cell"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1194\/jlr.R800054-JLR200","type":"journal-article","article-title":"Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL","volume":"50","author":"Brown","year":"2009","journal-title":"J Lipid Res"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.1016\/j.jprot.2012.03.043","type":"journal-article","article-title":"Site-specific phosphorylation of protein phosphatase 1 regulatory subunit 12A stimulated or suppressed by insulin","volume":"75","author":"Chao","year":"2012","journal-title":"J Proteomics"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.devcel.2007.07.007","type":"journal-article","article-title":"Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c","volume":"13","author":"Chen","year":"2007","journal-title":"Dev Cell"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/ncb2226","type":"journal-article","article-title":"Exocyst function is regulated by effector phosphorylation","volume":"13","author":"Chen","year":"2011a","journal-title":"Nat Cell Biol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1091\/mbc.E10-08-0665","type":"journal-article","article-title":"A Ral GAP complex links PI 3-kinase\/Akt signaling to RalA activation in insulin action","volume":"22","author":"Chen","year":"2011b","journal-title":"Mol Biol Cell"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1126\/science.1215909","type":"journal-article","article-title":"ER cargo properties specify a requirement for COPII coat rigidity mediated by Sec13p","volume":"335","author":"Copic","year":"2012","journal-title":"Science"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.tibs.2008.06.005","type":"journal-article","article-title":"PCSK9 and LDL cholesterol: unravelling the target to design the bullet","volume":"33","author":"Costet","year":"2008","journal-title":"Trends Biochem Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/nrm2025","type":"journal-article","article-title":"The COPII cage: unifying principles of vesicle coat assembly","volume":"7","author":"Gurkan","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1194\/jlr.R900015-JLR200","type":"journal-article","article-title":"Lipoproteomics: using mass spectrometry-based proteomics to explore the assembly, structure, and function of lipoproteins","volume":"50","author":"Hoofnagle","year":"2009","journal-title":"J Lipid Res"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"S172","DOI":"10.1194\/jlr.R800091-JLR200","type":"journal-article","article-title":"PCSK9: a convertase that coordinates LDL catabolism","volume":"50","author":"Horton","year":"2009","journal-title":"J Lipid Res"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"12027","DOI":"10.1073\/pnas.1534923100","type":"journal-article","article-title":"Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes","volume":"100","author":"Horton","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1172\/JCI116663","type":"journal-article","article-title":"Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery","volume":"92","author":"Ishibashi","year":"1993","journal-title":"J Clin Invest"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1242\/jcs.069773","type":"journal-article","article-title":"COPII-mediated vesicle formation at a glance","volume":"124","author":"Jensen","year":"2011","journal-title":"J Cell Sci"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nature10822","type":"journal-article","article-title":"Ubiquitin-dependent regulation of COPII coat size and function","volume":"482","author":"Jin","year":"2012","journal-title":"Nature"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/ng1145","type":"journal-article","article-title":"Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders","volume":"34","author":"Jones","year":"2003","journal-title":"Nat Genet"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1182\/blood-2012-01-292086","type":"journal-article","article-title":"The COPII pathway and hematologic disease","volume":"120","author":"Khoriaty","year":"2012","journal-title":"Blood"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1083\/jcb.200709012","type":"journal-article","article-title":"Biogenesis of gamma-secretase early in the secretory pathway","volume":"179","author":"Kim","year":"2007","journal-title":"J Cell Biol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"10134","DOI":"10.1074\/jbc.M111.283382","type":"journal-article","article-title":"SEC23-SEC31 the interface plays critical role for export of procollagen from the endoplasmic reticulum","volume":"287","author":"Kim","year":"2012","journal-title":"J Biol Chem"},{"key":"bib29","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0092-8674(02)00808-5","type":"journal-article","article-title":"mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery","volume":"110","author":"Kim","year":"2002","journal-title":"Cell"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/34438","type":"journal-article","article-title":"COPII-cargo interactions direct protein sorting into ER-derived transport vesicles","volume":"391","author":"Kuehn","year":"1998","journal-title":"Nature"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1038\/ng1880","type":"journal-article","article-title":"Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation","volume":"38","author":"Lang","year":"2006","journal-title":"Nat Genet"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","type":"journal-article","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1146\/annurev.cellbio.20.010403.105307","type":"journal-article","article-title":"Bi-directional protein transport between the ER and Golgi","volume":"20","author":"Lee","year":"2004","journal-title":"Annu Rev Cell Dev Biol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.cmet.2008.06.013","type":"journal-article","article-title":"Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism","volume":"8","author":"Li","year":"2008","journal-title":"Cell Metab"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1083\/jcb.200208074","type":"journal-article","article-title":"Concentrative sorting of secretory cargo proteins into COPII-coated vesicles","volume":"159","author":"Malkus","year":"2002","journal-title":"J Cell Biol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.molcel.2007.03.017","type":"journal-article","article-title":"The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope","volume":"26","author":"Mancias","year":"2007","journal-title":"Mol Cell"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"2918","DOI":"10.1038\/emboj.2008.208","type":"journal-article","article-title":"Structural basis of cargo membrane protein discrimination by the human COPII coat machinery","volume":"27","author":"Mancias","year":"2008","journal-title":"Embo J"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0092-8674(00)80608-X","type":"journal-article","article-title":"Vesicular tubular clusters between the ER and Golgi mediate concentration of soluble secretory proteins by exclusion from COPI-coated vesicles","volume":"98","author":"Martinez-Menarguez","year":"1999","journal-title":"Cell"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/ncb2002","type":"journal-article","article-title":"Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure","volume":"12","author":"Merte","year":"2010","journal-title":"Nat Cell Biol"},{"key":"bib40","doi-asserted-by":"crossref","first-page":"6105","DOI":"10.1093\/emboj\/cdf605","type":"journal-article","article-title":"Cargo selection into COPII vesicles is driven by the Sec24p subunit","volume":"21","author":"Miller","year":"2002","journal-title":"Embo J"},{"key":"bib41","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0092-8674(03)00609-3","type":"journal-article","article-title":"Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles","volume":"114","author":"Miller","year":"2003","journal-title":"Cell"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/nmeth.1226","type":"journal-article","article-title":"Mapping and quantifying mammalian transcriptomes by RNA-Seq","volume":"5","author":"Mortazavi","year":"2008","journal-title":"Nat Methods"},{"key":"bib43","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0092-8674(03)00608-1","type":"journal-article","article-title":"SNARE selectivity of the COPII coat","volume":"114","author":"Mossessova","year":"2003","journal-title":"Cell"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1111\/j.1600-0854.2007.00562.x","type":"journal-article","article-title":"The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR","volume":"8","author":"Nassoury","year":"2007","journal-title":"Traffic"},{"key":"bib45","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0092-8674(00)81146-0","type":"journal-article","article-title":"Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII","volume":"93","author":"Nichols","year":"1998","journal-title":"Cell"},{"key":"bib46","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1126\/science.1096303","type":"journal-article","article-title":"Intracellular aspects of the process of protein synthesis","volume":"189","author":"Palade","year":"1975","journal-title":"Science"},{"key":"bib47","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1074\/jbc.275.15.11521","type":"journal-article","article-title":"Evidence for overlapping and distinct functions in protein transport of coat protein Sec24p family members","volume":"275","author":"Peng","year":"2000","journal-title":"J Biol Chem"},{"key":"bib48","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1073\/pnas.89.10.4471","type":"journal-article","article-title":"Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells","volume":"89","author":"Piedrahita","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib49","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1083\/jcb.145.4.659","type":"journal-article","article-title":"LST1 is a SEC24 homologue used for selective export of the plasma membrane ATPase from the endoplasmic reticulum","volume":"145","author":"Roberg","year":"1999","journal-title":"J Cell Biol"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"D912","DOI":"10.1093\/nar\/gkr1012","type":"journal-article","article-title":"ENCODE whole-genome data in the UCSC Genome Browser: update 2012","volume":"40","author":"Rosenbloom","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.cell.2008.12.025","type":"journal-article","article-title":"TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites","volume":"136","author":"Saito","year":"2009","journal-title":"Cell"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1091\/mbc.E11-02-0143","type":"journal-article","article-title":"cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites","volume":"22","author":"Saito","year":"2011","journal-title":"Mol Biol Cell"},{"key":"bib53","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1186\/1471-2105-7-538","type":"journal-article","article-title":"Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments","volume":"7","author":"Sartor","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1038\/ng.405","type":"journal-article","article-title":"Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II","volume":"41","author":"Schwarz","year":"2009","journal-title":"Nat Genet"},{"key":"bib55","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1083\/jcb.151.5.973","type":"journal-article","article-title":"Lst1p and Sec24p cooperate in sorting of the plasma membrane ATPase into COPII vesicles in Saccharomyces cerevisiae","volume":"151","author":"Shimoni","year":"2000","journal-title":"J Cell Biol"},{"key":"bib56","doi-asserted-by":"publisher","DOI":"10.2202\/1544-6115.1027","type":"journal-article","article-title":"Linear models and empirical Bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"26483","DOI":"10.1074\/jbc.M504041200","type":"journal-article","article-title":"Insig required for sterol-mediated inhibition of Scap\/SREBP binding to COPII proteins in vitro","volume":"280","author":"Sun","year":"2005","journal-title":"J Biol Chem"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"6519","DOI":"10.1073\/pnas.0700907104","type":"journal-article","article-title":"Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins","volume":"104","author":"Sun","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"E2001","DOI":"10.1073\/pnas.1209207109","type":"journal-article","article-title":"SEC23B is required for the maintenance of murine professional secretory tissues","volume":"109","author":"Tao","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/nature09270","type":"journal-article","article-title":"Biological, clinical and population relevance of 95 loci for blood lipids","volume":"466","author":"Teslovich","year":"2010","journal-title":"Nature"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1111\/j.1600-0854.2009.00989.x","type":"journal-article","article-title":"Bulk flow revisited: transport of a soluble protein in the secretory pathway","volume":"10","author":"Thor","year":"2009","journal-title":"Traffic"},{"key":"bib62","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0092-8674(00)81006-5","type":"journal-article","article-title":"Bulk flow redux?","volume":"98","author":"Warren","year":"1999","journal-title":"Cell"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/sj.embor.7400893","type":"journal-article","article-title":"Role of Sec24 isoforms in selective export of membrane proteins from the endoplasmic reticulum","volume":"8","author":"Wendeler","year":"2007","journal-title":"EMBO Rep"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"16904","DOI":"10.1073\/pnas.1012050107","type":"journal-article","article-title":"Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele","volume":"107","author":"Westrick","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib65","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0092-8674(87)90224-8","type":"journal-article","article-title":"The rate of bulk flow from the endoplasmic reticulum to the cell surface","volume":"50","author":"Wieland","year":"1987","journal-title":"Cell"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.jasms.2005.12.010","type":"journal-article","article-title":"Quantification of phosphorylation of insulin receptor substrate-1 by HPLC-ESI-MS\/MS","volume":"17","author":"Yi","year":"2006","journal-title":"J Am Soc Mass Spectrom"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/ncb2390","type":"journal-article","article-title":"COPII and the regulation of protein sorting in mammals","volume":"14","author":"Zanetti","year":"2011","journal-title":"Nat Cell Biol"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1126\/science.1168974","type":"journal-article","article-title":"LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor","volume":"325","author":"Zelcer","year":"2009","journal-title":"Science"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/ng1153","type":"journal-article","article-title":"Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex","volume":"34","author":"Zhang","year":"2003","journal-title":"Nat Genet"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"25881","DOI":"10.1074\/jbc.M502160200","type":"journal-article","article-title":"LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway","volume":"280","author":"Zhang","year":"2005","journal-title":"J Biol Chem"},{"key":"bib71","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1411543","type":"journal-article","article-title":"Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E","volume":"258","author":"Zhang","year":"1992","journal-title":"Science"}],"updated-by":[{"DOI":"10.7554\/elife.112375","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000}}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/00444\/elife-00444-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/00444\/elife-00444-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/00444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:45:46Z","timestamp":1782301546000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/00444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,9]]},"references-count":71,"alternative-id":["10.7554\/eLife.00444"],"URL":"https:\/\/doi.org\/10.7554\/elife.00444","archive":["CLOCKSS"],"relation":{"has-review":[{"id-type":"doi","id":"10.7554\/eLife.00444.016","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.00444.017","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718009440.793476493","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718009440.793481073","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,9]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e00444"}}