{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:56:16Z","timestamp":1790690176233,"version":"4.1.0"},"reference-count":79,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP7\/2007-2013 no. 340904 (EvolvingNodules)"],"award-info":[{"award-number":["FP7\/2007-2013 no. 340904 (EvolvingNodules)"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Symbiosis Receptor-like Kinase (SYMRK) is indispensable for the development of phosphate-acquiring arbuscular mycorrhiza (AM) as well as nitrogen-fixing root nodule symbiosis, but the mechanisms that discriminate between the two distinct symbiotic developmental fates have been enigmatic. In this study, we show that upon ectopic expression, the receptor-like kinase genes\n                    <jats:italic>Nod Factor Receptor 1 (NFR1)<\/jats:italic>\n                    ,\n                    <jats:italic>NFR5,<\/jats:italic>\n                    and\n                    <jats:italic>SYMRK<\/jats:italic>\n                    initiate spontaneous nodule organogenesis and nodulation-related gene expression in the absence of rhizobia. Furthermore, overexpressed NFR1 or NFR5 associated with endogenous SYMRK in roots of the legume\n                    <jats:italic>Lotus japonicus<\/jats:italic>\n                    . Epistasis tests revealed that the dominant active\n                    <jats:italic>SYMRK<\/jats:italic>\n                    allele initiates signalling independently of either the\n                    <jats:italic>NFR1<\/jats:italic>\n                    or\n                    <jats:italic>NFR5<\/jats:italic>\n                    gene and upstream of a set of genes required for the generation or decoding of calcium-spiking in both symbioses. Only\n                    <jats:italic>SYMRK<\/jats:italic>\n                    but not\n                    <jats:italic>NFR<\/jats:italic>\n                    overexpression triggered the expression of AM-related genes, indicating that the receptors play a key role in the decision between AM- or root nodule symbiosis-development.\n                  <\/jats:p>","DOI":"10.7554\/elife.03891","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T05:42:37Z","timestamp":1416894157000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.03891","source":"Crossref","is-referenced-by-count":96,"title":["Spontaneous symbiotic reprogramming of plant roots triggered by receptor-like kinases"],"prefix":"10.7554","volume":"3","author":[{"given":"Martina Katharina","family":"Ried","sequence":"first","affiliation":[{"name":"Faculty of Biology, Ludwig Maximilians University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meritxell","family":"Antol\u00edn-Llovera","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Ludwig Maximilians University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8561-747X","authenticated-orcid":true,"given":"Martin","family":"Parniske","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Ludwig Maximilians University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2014,11,25]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.cub.2013.12.053","article-title":"Cleavage of the SYMBIOSIS RECEPTOR-LIKE KINASE ectodomain promotes complex formation with Nod Factor Receptor 5","volume":"24","author":"Antol\u00edn-Llovera","year":"2014","journal-title":"Current 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