{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:59:01Z","timestamp":1791219541116,"version":"4.1.0"},"reference-count":12,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T00:00:00Z","timestamp":1422230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T00:00:00Z","timestamp":1422230400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T00:00:00Z","timestamp":1422230400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009827","name":"Laura and John Arnold Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009827","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registered report describes the proposed replication plan of key experiments from \u2018Transcriptional amplification in tumor cells with elevated c-Myc\u2019 by &lt;xref ref-type=\"bibr\" rid=\"bib5\"&gt;Lin et al. (2012)&lt;\/xref&gt;, published in Cell in 2012. The experiments that will be replicated are those reported in Figures 3E and 3F. In these experiments, elevated levels of c-Myc in the P493-6 cell model of Burkitt's lymphoma results in an increase of the total level of RNA using UV\/VIS spectrophotometry (Figure 3E; &lt;xref ref-type=\"bibr\" rid=\"bib5\"&gt;Lin et al., 2012&lt;\/xref&gt;) and on the mRNA levels\/cell for a large set of genes using digital gene expression technology (Figure 3F; &lt;xref ref-type=\"bibr\" rid=\"bib5\"&gt;Lin et al., 2012&lt;\/xref&gt;). 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